We have, thus far, focused on utilizing functional neuroimaging to discern substrates of movement control and movement relearning-related plasticity in a post-stroke brain to draw upon their significance for rehabilitation. Furthermore, using noninvasive brain stimulation, including transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS), we have explored ways to harness plasticity within implicated…
My laboratory’s research interests broadly include brain stimulation, motor control, neuroimaging, clinical neuroscience and rehabilitation. We have, thus far, focused on utilizing functional neuroimaging to discern substrates of movement control and movement relearning-related plasticity in the healthy vs. post-stroke brain to draw upon their significance for rehabilitation. Furthermore, using noninvasive brain stimulation, including transcranial magnetic…
Electrical activation of the paralyzed neuromuscular system (functional electrical stimulation-FES) provides a means for restoration of control of the paralyzed extremities. My research involves the development of neuroprostheses that use FES to restore hand/arm control to individuals of cervical level spinal cord injury (quadriplegia). Areas of Interest FES systems for control of the extremity including…
Dr. Onders spent his early years at UH developing a minimally invasive procedure to allow ventilator-free breathing for paralyzed patients. More recently, Dr. Onders has led the effort to apply that same technology in patients with the progressive neurological disorder Amyotrophic Lateral Sclerosis (ALS). Publications (Select) Entire publication list can be found here. Publications Onders…
Mapping the epileptogenic zone as well as epileptic and functional brain networks is a cornerstone principle in guiding therapeutics for patients with medically intractable epilepsy. Accurate identification of these regions is necessary to achieve seizure freedom and avoiding functional deficits. We believe that mapping of these regions will be informed principally by clinical neurophysiologic data…
In 2013, after two years in practice at the regional level I trauma hospital, MetroHealth Medical Center, I joined the Center for Neurological Restoration at the Cleveland Clinic where I now focus on the neurosurgical management of movement disorders, pain, cranial vault reconstruction, spasticity and hydrocephalus in the adult. In this role, I set the…
As the Executive Director of the Institute for Functional Restoration, a non-profit organization within Case Western Reserve University, I work with FES Center investigators to chart the commercialization pathways for orphan market technologies that restore function. In this role, I set the strategic direction for the IFR, establishing partnerships with key stakeholders within industry, foundations,…
The brain contains billions of nerve cells, or neurons, which receive and integrate signals from the environment, and which govern the body’s responses. Nervous system activity is made possible by synapses, contacts formed either between neurons or between a neuron and a target cell. Synapses are asymmetric structures in which neurotransmitter molecules are released from…
Dr. Mehra is a physician scientist with a longstanding commitment of ~15 years to the investigation of clinical and translational science of sleep disorders and cardiovascular disease utilizing epidemiologic and clinical trials methods. She is a board certified Pulmonary, Critical Care and Sleep Medicine physician with advanced Sleep Medicine Neurobiology and Epidemiology training via a…
Dr. Megerian is an expert for patients who need to manage hearing loss, chronic ear disease, cholesteoma, otosclerosis, vertigo, and countless other otology and neurotology issues. He is also an expert in the diagnosis and treatment of acoustic neuroma. He has published over 120 peer reviewed manuscripts and abstracts and has served as visiting professor…