Effects of Deep Brain Stimulation on Parkinsonian Gait Disorders
The overarching goal of this project is to understand the physiological underpinnings of gait deficits in Parkinson’s Disease (PD).
About This Study
The impact of this study is designed to lead to the development of
- Quantitative tests for context dependent gait abnormalities, such as freezing of gait induced by doorway passage or turning when visual and non-visual inputs are at odds.
- Next generation DBS technology through identification of stimulated neural pathways that are maximally correlated with improvement in gait function in PD.
The trial will examine two main concepts
- Whether conflicting visual and non-visual (e.g. vestibular and proprioceptive) sensory signals are responsible for the gait abnormalities and how subthalamic DBS influences gait abnormalities induced by visual-nonvisual conflict.
- Which neural pathways are critical in mediating the effects of subthalamic DBS when it is successful in treating gait disorders in PD.
Principal Investigator: Aasef Shaikh, MD, PhD
Program Contact: Aasef Shaikh, MD, PhD
Contact Email: Aasef.Shaikh@case.edu
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