Contralaterally Controlled Functional Electrical Stimulation Plus Video Games for Hand Therapy After Stroke

The purpose of this project is to see if the effects of CCFES can be increased.

This study will demonstrate the supplemental motor relearning value of virtual reality/video games to CCFES therapy, identify patients most likely to respond to both therapies, and determine whether adding Hand Therapy Video Games (HTVG) to CCFES changes how the brain functions.

About This Study

The objectives of this project are to compare how CCFES and CCFES+HTVG affect arm and hand movement, to determine if the effectiveness of our treatment depends on how long ago the stroke was or how severely the stroke affected hand movement, and to compare how CCFES and CCFES+HTVG affect how the brain activates when trying to move the hand.

Study Information

A single-blinded randomized controlled trial will be carried out to assess the effects of 12 weeks of Contralaterally Controlled Functional Electrical Stimulation (CCFES) +Hand Therapy Video Games (HTVG) compared to CCFES. Dexterity, upper limb impairment, and activity limitation will be assessed at 0 (baseline), 3, 6, 9, 12 (end of treatment), 24, and 36 wks. Cortical activation (measured with fMRI) will be assessed at 0 and 12 wks. The treatment dose will be the same for both groups: 10 sessions per week (7.5 hrs) of self-administered treatment at home plus 2 sessions per week (3 hrs) of group-specific occupational therapy in the lab.

Detailed program information and criteria available at:


Non-Invasive, Innovative FES Treatments for Stroke

Principal Investigators: Jayme Knutson, PhD

Program Contact: Amy Friedl

Contact Number: (216) 957-3558

Contact Email:

Contact Request

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