Molecular Mechanisms of Neuromuscular Junction

Mechanisms of Neuromuscular Junction Formation The long term goal of this study is to understand mechanisms underlying functional recovery from muscle and nerve injuries. About this Study This study will investigate the role of agrin signaling in neuromuscular junction (NMJ) regeneration. Results will provide a better understanding of agrin signaling in NMJ regeneration, a prerequisite…

Lower Extremity Exercise

The Cyclical Lower-extremity Exercise (CYCLE) Trial for Parkinson’s disease The primary aim of this project is to determine if long-term, high intensity aerobic exercise alters disease progression in individuals with Parkinson’s Disease. About This Study Identification of an effective disease-modifying intervention (e.g. pharmaceutical, surgical or behavioral) is an unmet need in Parkinson’s disease (PD). Increasing…

Parkinson’s

Parkinson’s disease is a brain disorder that leads to shaking, stiffness, and difficulty with walking, balance, and coordination. Symptoms usually begin gradually and get worse over time. As the disease progresses, people may have difficulty walking and talking. They may also have mental and behavioral changes, sleep problems, depression, memory difficulties, and fatigue. One clear…

Sleep Apnea

Sleep apnea is a common disorder in which an individual has one or more pauses in breathing or shallow breaths while he or she sleeps. Breathing pauses can last from a few seconds to minutes, generally occurring 30 or more times an hour. Generally, sleep apnea is a chronic condition which causes disruption to one’s…

Clinical Trials

Research Goals Within each of the active clinical protocols, real human needs are being addressed to bring research and technology advances into the clinic. Regulatory oversight is addressed through dedicated staff working with the individual investigators. Leading the charge with the research community, the FES Center continues to expand and review these human subject programs…

Fundamental Studies

Fundamental Studies Overview Fundamental studies develop hypotheses which are used as the foundation for applied science. Nerve Block for Pain Molecular Mechanisms of Neuromuscular Junction Tools for Deep Brain Stimulation Understanding Ganglion Organization Implanted Blood Pressure Sensor Novel STN Patterns – Parkinson’s Disease