Areas of Interest

  • Neurology
  • Neurosurgery
  • Deep brain stimulation
  • Movement disorders

Research Programs

  • Modeling of Neural Systems
  • Electric Field Generated by Deep Brain Stimulation
  • Systems-Level Model of Deep Brain Stimulation
  • Patient-Specific Models of Deep Brain Stimulation
  • Deep Brain Stimulation Interactive Visualization System
  • Cortical Closed-Loop Control of Deep Brain Stimulation

Publications (Select)

  • Maling N, Lempka SF, Blumenfeld Z, Bronte-Stewart HM, McIntyre CCBiophysical Basis of Subthalamic Local Field Potentials Recorded from Deep Brain Stimulation Electrodes. J Neurophysiol. 2018 Jul 18; doi: 10.1152/jn.00067.2018 Pubmed PMID: 30020838
  • Gunalan K, Howell B, McIntyre CC. Quantifying axonal responses in patient-specific models of subthalamic deep brain stimulation. Neuroimage. 2018 May 15;172:263–277. doi: 10.1016/j.neuroimage.2018.01.015 Pubmed PMID: 29331449
  • Anderson RW, Farokhniaee A, Gunalan K, Howell B, McIntyre CC. Action potential initiation, propagation, and cortical invasion in the hyperdirect pathway during subthalamic deep brain stimulation. Brain Stimul. 2018 May 12; doi: 10.1016/j.brs.2018.05.008 Pubmed PMID: 29779963
  • Riva-Posse P, Choi KS, Holtzheimer PE, Crowell AL, Garlow SJ, Rajendra JK, McIntyre CC, Gross RE, Mayberg HS. A connectomic approach for subcallosal cingulate deep brain stimulation surgery: prospective targeting in treatment-resistant depression. Mol Psychiatry. 2018 Apr;23(4):843–849. doi: 10.1038/mp.2017.59 Pubmed PMID: 28397839
  • Lempka SF, Howell B, Gunalan K, Machado AG, McIntyre CC. Characterization of the stimulus waveforms generated by implantable pulse generators for deep brain stimulation. Clin Neurophysiol. 2018 Apr;129(4):731–742. doi: 10.1016/j.clinph.2018.01.015 Pubmed PMID: 29448149
  • Choi KS, Noecker AM, Riva-Posse P, Rajendra JK, Gross RE, Mayberg HS, McIntyre CCImpact of brain shift on subcallosal cingulate deep brain stimulation. Brain Stimul. 2018 Apr;11(2):445–453. doi: 10.1016/j.brs.2017.12.001 Pubmed PMID: 29246748
  • Noecker AM, Choi KS, Riva-Posse P, Gross RE, Mayberg HS, McIntyre CC. StimVision Software: Examples and Applications in Subcallosal Cingulate Deep Brain Stimulation for Depression. Neuromodulation. 2018 Feb;21(2):191–196. doi: 10.1111/ner.12625 Pubmed PMID: 28653482
  • Gunalan K, Chaturvedi A, Howell B, Duchin Y, Lempka SF, Patriat R, Sapiro G, Harel N, McIntyre CCCreating and parameterizing patient-specific deep brain stimulation pathway-activation models using the hyperdirect pathway as an example. PLoS One. 2017 Apr 25;12(4):e0176132. doi: 10.1371/journal.pone.0176132. eCollection 2017. PubMed PMID: 28441410; PubMed Central PMCID: PMC5404874.
  • Hamel W, Köppen JA, Alesch F, Antonini A, Barcia JA, Bergman H, Chabardes S, Contarino MF, Cornu P, Demmel W, Deuschl G, Fasano A, Kühn AA, Limousin P, McIntyre CC, Mehdorn HM, Pilleri M, Pollak P, Rodríguez-Oroz MC, Rumià J, Samuel  M, Timmermann L, Valldeoriola F, Vesper J, Visser-Vandewalle V, Volkmann J, Lozano AM. Targeting of the Subthalamic Nucleus for Deep Brain Stimulation: A Survey Among Parkinson Disease Specialists. World Neurosurg. 2017 Mar;99:41-46. doi: 10.1016/j.wneu.2016.11.012. Epub 2016 Nov 9. PubMed PMID: 27838430.
  • Howell B, McIntyre CC. Role of Soft-Tissue Heterogeneity in Computational Models of Deep Brain Stimulation. Brain Stimul. 2017 Jan – Feb;10(1):46-50. doi: 10.1016/j.brs.2016.09.001. Epub 2016 Sep 8. PubMed PMID: 27720186; PubMed Central PMCID: PMC5241242.
  • McIntyre CC, Anderson RW. Deep brain stimulation mechanisms: the control of network activity via neurochemistry modulation. J Neurochem. 2016 Oct;139 Suppl 1:338-345. doi: 10.1111/jnc.13649. Epub 2016 Jun 8. Review. PubMed PMID: 27273305; PubMed Central PMCID: PMC5358920.
  • Howell B, McIntyre CCAnalyzing the tradeoff between electrical complexity and accuracy in patient-specific computational models of deep brain stimulation.  J Neural Eng. 2016 Jun;13(3):036023. doi: 10.1088/1741 2560/13/3/036023. Epub 2016 May 11. PubMed PMID: 27172137; PubMed Central PMCID: PMC5259803.
  • Rossi PJ, Gunduz A, Judy J, Wilson L, Machado A, Giordano JJ, Elias WJ, Rossi  MA, Butson CL, Fox MD, McIntyre CC, Pouratian N, Swann NC, de Hemptinne C, Gross  RE, Chizeck HJ, Tagliati M, Lozano AM, Goodman W, Langevin JP, Alterman RL, Akbar U, Gerhardt GA, Grill WM, Hallett M, Herrington T, Herron J, van Horne C, Kopell  BH, Lang AE, Lungu C, Martinez-Ramirez D, Mogilner AY, Molina R, Opri E, Otto KJ, Oweiss KG, Pathak Y, Shukla A, Shute J, Sheth SA, Shih LC, Steinke GK, Tröster AI, Vanegas N, Zaghloul KA, Cendejas-Zaragoza L, Verhagen L, Foote KD, Okun MS. Proceedings of the Third Annual Deep Brain Stimulation Think Tank: A Review of Emerging Issues and Technologies. Front Neurosci. 2016 Apr 6;10:119. doi: 10.3389/fnins.2016.00119. eCollection 2016. Review. PubMed PMID: 27092042; PubMed Central PMCID: PMC4821860.
  • Hartmann CJ, Lujan JL, Chaturvedi A, Goodman WK, Okun MS, McIntyre CC, Haq IU. Tractography Activation Patterns in Dorsolateral Prefrontal Cortex Suggest Better Clinical Responses in OCD DBS. Front Neurosci. 2016 Jan 19;9:519. doi: 10.3389/fnins.2015.00519. eCollection 2015. PubMed PMID: 26834544; PubMed Central PMCID: PMC4717315.
  • Shamir RR, Dolber T, Noecker AM, Walter BL, McIntyre CCMachine Learning Approach to Optimizing Combined Stimulation and Medication Therapies for Parkinson’s Disease. Brain Stimul. 2015 Jun 15; doi: 10.1016/j.brs.2015.06.003 Pubmed PMID: 26140956
  • Lempka SF, McIntyre CC, Kilgore KL, Machado AG. Computational analysis of kilohertz frequency spinal cord stimulation for chronic pain management. Anesthesiology. 2015 Jun;122(6):1362–1376. doi: 10.1097/ALN.0000000000000649Pubmed PMID: 25822589
  • Van Dijk KJ, Verhagen R, Chaturvedi A, McIntyre CC, Bour LJ, Heida C, Veltink PH. A novel lead design enables selective deep brain stimulation of neural populations in the subthalamic region. J Neural Eng. 2015 May 28;12(4):046003. doi: 10.1088/1741-2560/12/4/046003Pubmed PMID: 26020096
  • Reich MM, Steigerwald F, Sawalhe AD, Reese R, Gunalan K, Johannes S, Nickl R, Matthies C, McIntyre CC, Volkmann J. Short pulse width widens the therapeutic window of subthalamic neurostimulation. Ann Clin Transl Neurol. 2015 Apr;2(4):427–432. doi: 10.1002/acn3.168 Pubmed PMID: 25909087
  • McIntyre CC, Chaturvedi A, Shamir RR, Lempka SF. Engineering the next generation of clinical deep brain stimulation technology. Brain Stimul. 2015 Feb;8(1):21–26. doi: 10.1016/j.brs.2014.07.039Pubmed PMID: 25161150
  • Riva-Posse P, Choi KS, Holtzheimer PE, McIntyre CC, Gross RE, Chaturvedi A, Crowell AL, Garlow SJ, Rajendra JK, Mayberg HS.Defining critical white matter pathways mediating successful subcallosal cingulate deep brain stimulation for treatment-resistant depression. Biol Psychiatry. 2014 Dec 15;76(12):963–969. doi: 10.1016/j.biopsych.2014.03.029 Pubmed PMID: 24832866
  • Sweet JA, Walter BL, Miller JP, McIntyre CC. Response. J Neurosurg. 2014 Aug;121(2):495. Pubmed PMID: 25221808
  • Cheung T, Noecker AM, Alterman RL, McIntyre CC, Tagliati M. Defining a therapeutic target for pallidal deep brain stimulation for dystonia. Ann Neurol. 2014 Jul;76(1):22–30. doi: 10.1002/ana.24187Pubmed PMID: 24852850
  • Sweet JA, Walter BL, Gunalan K, Chaturvedi A, McIntyre CC, Miller JP. Fiber tractography of the axonal pathways linking the basal ganglia and cerebellum in Parkinson disease: implications for targeting in deep brain stimulation. J Neurosurg. 2014 Apr;120(4):988–996. doi: 10.3171/2013.12.JNS131537 Pubmed PMID: 24484226
  • Shamir RR, Dolbert T, Noecker AM, Frankemolle AM, Walter BL,McIntyre CCA method for predicting the outcomes of combined pharmacologic and deep brain stimulation therapy for Parkinson’s disease. Med Image Comput Comput Assist Interv. 2014;17(Pt 2):188–195. Pubmed PMID: 25485378
  • Cooper SE, Driesslein KG, Noecker AM, McIntyre CC, Machado AM, Butson CR. Anatomical targets associated with abrupt versus gradual washout of subthalamic deep brain stimulation effects on bradykinesia. PLoS ONE. 2014;9(8):e99663. doi: 10.1371/journal.pone.0099663 Pubmed PMID: 25098453
  • Chaturvedi A, Luján JL, McIntyre CCArtificial neural network based characterization of the volume of tissue activated during deep brain stimulation. J Neural Eng. 2013 Oct;10(5):056023. doi: 10.1088/1741-2560/10/5/056023 Pubmed PMID: 24060691
  • Arlow RL, Foutz TJ, McIntyre CC. Theoretical principles underlying optical stimulation of myelinated axons expressing channelrhodopsin-2. Neuroscience. 2013 Sep 17;248:541–551. doi: 10.1016/j.neuroscience.2013.06.031 Pubmed PMID: 23811392
  • Lujan JL, Chaturvedi A, Choi KS, Holtzheimer PE, Gross RE, Mayberg HS, McIntyre CCTractography-activation models applied to subcallosal cingulate deep brain stimulation. Brain Stimul. 2013 Sep;6(5):737–739. doi: 10.1016/j.brs.2013.03.008 Pubmed PMID: 23602025
  • Dietz J, Noecker AM, McIntyre CC, Mikos A, Bowers D, Foote KD, Okun MS. Stimulation region within the globus pallidus does not affect verbal fluency performance. Brain Stimul. 2013 May;6(3):248–253. doi: 10.1016/j.brs.2012.05.011 Pubmed PMID: 22766102
  • Cooper SE, McIntyre CC, Fernandez HH, Vitek JL. Association of deep brain stimulation washout effects with Parkinson disease duration. JAMA Neurol. 2013 Jan;70(1):95–99. doi: 10.1001/jamaneurol.2013.581 Pubmed PMID: 23070397


Associate Director of Industrial Relations
Cleveland FES Center

Tilles-Weidenthal Professor, School of Medicine, Department of Biomedical Engineering
Case Western Reserve University

Biomedical Engineer
Louis Stokes Cleveland VA Medical Center


Program Contact
Cameron McIntyre

Contact Number
(216) 368-5869

Contact Email