My research centers on development and clinical trials of new interventions for training and restoring human function after neurologic injury.

These interventions are the result of translating technologies from the areas of robotics, human-computer interfaces, and virtual environments.

Research Programs

Publications (Select)

Entire publication list can be found here.

  • Kilgore KL, Bryden A, Keith MW, Hoyen HA, Hart RL, Nemunaitis GA, Peckham PH. Evolution of Neuroprosthetic Approaches to Restoration of Upper Extremity Function in Spinal Cord Injury. Top Spinal Cord Inj Rehabil. 2018 Summer;24(3):252-264. doi: 10.1310/sci2403-252. PubMed PMID: 29997428; PubMed Central PMCID: PMC6037324.
  • Ajiboye AB, Willett FR, Young DR, Memberg WD, Murphy BA, Miller JP, Walter BL, Sweet JA, Hoyen HA, Keith MW, Peckham PH, Simeral JD, Donoghue JP, Hochberg LR, Kirsch RF. Restoration of reaching and grasping movements through brain-controlled muscle stimulation in a person with tetraplegia: a proof-of-concept demonstration. Lancet. 2017 May 6;389(10081):1821-1830. doi: 10.1016/S0140-6736(17)30601-3. Epub 2017 Mar 28. PubMed PMID: 28363483.
  • Peterson CL, Rogers LM, Bednar MS, Bryden AM, Keith MW, Perreault EJ, Murray WM. Posture-Dependent Corticomotor Excitability Differs Between the Transferred Biceps in Individuals With Tetraplegia and the Biceps of Nonimpaired Individuals. Neurorehabil Neural Repair. 2017 Apr;31(4):354-363. doi: 10.1177/1545968316680488. Epub 2016 Dec 8. PubMed PMID: 27932695; PubMed Central  PMCID: PMC5364050.
  • Peterson CL, Bednar MS, Bryden AM, Keith MW, Perreault EJ, Murray WM. Voluntary activation of biceps-to-triceps and deltoid-to-triceps transfers in quadriplegia. PLoS One. 2017 Mar 2;12(3):e0171141. doi: 10.1371/journal.pone.0171141. eCollection 2017. PubMed PMID: 28253262; PubMed Central PMCID: PMC5333805.
  • Graham B, Peljovich AE, Afra R, Cho MS, Gray R, Stephenson J, Gurman A, MacDermid J, Mlady G, Patel AT, Rempel D, Rozental TD, Salajegheh MK, Keith MW, Jevsevar DS, Shea KG, Bozic KJ, Adams J, Evans JM, Lubahn J, Ray WZ, Spinner R, Thomson G, Shaffer WO, Cummins DS, Murray JN, Mohiuddin M, Mullen K, Shores P, Woznica A, Linskey E, Martinez Y, Sevarino K. The American Academy of Orthopaedic Surgeons Evidence-Based Clinical Practice Guideline on: Management of Carpal Tunnel Syndrome. J Bone Joint Surg Am. 2016 Oct 19;98(20):1750-1754. PubMed PMID: 27869627.
  • Bryden AM, Hoyen HA, Keith MW, Mejia M, Kilgore KL, Nemunaitis GA. Upper Extremity Assessment in Tetraplegia: The Importance of Differentiating Between Upper and Lower Motor Neuron Paralysis. Arch Phys Med Rehabil. 2016 Jun;97(6 Suppl):S97-S104. doi: 10.1016/j.apmr.2015.11.021. PubMed PMID: 27233597.
  • Tan DW, Schiefer MA, Keith MW, Anderson JR, Tyler DJ. Stability and selectivity of a chronic, multi-contact cuff electrode for sensory stimulation in human amputees. J Neural Eng. 2015 Jan 28;12(2):026002. doi: 10.1088/1741-2560/12/2/026002 Pubmed PMID: 25627310
  • Tan DW, Schiefer MA, Keith MW, Anderson JR, Tyler J, Tyler DJ. A neural interface provides long-term stable natural touch perception.Sci Transl Med. 2014 Oct 8;6(257):257ra138. doi: 10.1126/scitranslmed.3008669 Pubmed PMID: 25298320
  • Peterson CL, Rogers LM, Mogk JPM, Bednar MS, Bryden AM, Keith MW, Perreault EJ, Murray WM. Posture-dependent changes in corticomotor excitability of the biceps after spinal cord injury and tendon transfer. Conf Proc IEEE Eng Med Biol Soc. 2014 Aug;2014:4302–4305. doi: 10.1109/EMBC.2014.6944576 Pubmed PMID: 25570944
  • Memberg WD, Polasek KH, Hart RL, Bryden AM, Kilgore KL, Nemunaitis GA, Hoyen HA, Keith MW, Kirsch RF. Implanted neuroprosthesis for restoring arm and hand function in people with high level tetraplegia. Arch Phys Med Rehabil. 2014 Jun;95(6):1201-1211.e1. doi: 10.1016/j.apmr.2014.01.028. Epub 2014 Feb 20. PubMed PMID: 24561055.
  • Members of the Writing, Review, and Voting Panels of the AUC on Optimizing the Management of Full-Thickness Rotator Cuff Tears, Sanders JO, Keith MW, Murray J, Pezold R. The American Academy of Orthopaedic Surgeons appropriate use criteria on optimizing the management of full-thickness rotator cuff tears. J Bone Joint Surg Am. 2014 Apr 16;96(8):683-4. doi: 10.2106/JBJS.M.01541. PubMed PMID: 24740665.
  • Hammert WC, Kramer RC, Graham B, Keith MWAAOS appropriate use criteria: treatment of distal radius fractures. J Am Acad Orthop Surg. 2013 Aug;21(8):506-9. doi: 10.5435/JAAOS-21-08-506. PubMed PMID: 23908257.
  • Chambers HG, Shea KG, Anderson AF, Jojo Brunelle TJ, Carey JL, Ganley TJ, Paterno M, Weiss JM, Sanders JO, Watters WC 3rd, Goldberg MJ, Keith MW, Turkelson CM, Wies JL, Raymond L, Boyer KM, Hitchcock K, Sluka P, Boone C, Patel N;American Academy of Orthopaedic Surgeons. American Academy of Orthopaedic Surgeons clinical practice guideline on: the diagnosis and treatment of osteochondritis dissecans. J Bone Joint Surg Am. 2012 Jul 18;94(14):1322-4. doi: 10.2106/JBJS.9414ebo. Erratum in: J Bone Joint Surg Am. 2013 Mar 20;95(6):e35. Weiss, Jennifer M [added].PubMedPMID: 22810404.
  • Keith MW, Peljovich A.Surgical treatments to restore function control in spinal cord injury. Handb Clin Neurol.2012;109:167-79. doi: 10.1016/B978-0-444-52137-8.00010-3. Review. PubMed PMID:23098712.
  • Knutson JS, Chae J, Hart RL, Keith MW, Hoyen HA, Harley MY, Hisel TZ, Bryden AM, Kilgore KL, Peckham H. Implanted neuroprosthesis for assisting arm and hand function after stroke: a case study. J Rehabil Res Dev. 2012;49(10):1505-16. PubMed PMID: 23516054; PubMed Central PMCID: PMC3605749.


Cleveland FES Center

Chief, Hand Service, Department of Orthopaedics
MetroHealth Medical Center

Professor, Department of Orthopaedics, School of Medicine; and Professor, Department of Biomedical Engineering
Case Western Reserve University

Louis Stokes Cleveland VA Medical Center


Program Contact
Melissa Evans

Contact Number
(216) 778-3621

Contact Email,