Dr. Jacono’s research interests are focused on the neural control of breathing in acute lung injury (ALI), acute respiratory distress syndrome (ARDS) and mechanical ventilation.

The overall goal of his laboratory is to develop and test a cohesive set of computational approaches to quantify biologically determined breathing pattern variability to provide predicative insight into prognosis and reversible pathophysiology leading to recovery, survival and rehabilitation; ultimately, targeting measures of pattern variability as an “additional vital sign” providing diagnostic and predictive information to clinicians.

Dr. Jacono received an Advanced Career Development Award from the VA Research Service, and his research activities have also been supported by the American Heart Association and the NIH.

Publications (Select)

Entire publication list can be found here.

  • Warren PM, Campanaro C, Jacono FJ, Alilain WJ. Mid-cervical spinal cord contusion causes robust deficits in respiratory parameters and pattern variability. Exp Neurol. 2018 Aug;306:122-131. doi: 10.1016/j.expneurol.2018.04.005. Epub 2018 Apr 10. PubMed PMID: 29653187.
  • Darrah RJ, Jacono FJ, Joshi N, Mitchell AL, Sattar A, Campanaro CK, Litman P, Frey J, Nethery DE, Barbato ES, Hodges CA, Corvol H, Cutting GR, Knowles MR, Strug LJ, Drumm ML. AGTR2 absence or antagonism prevents cystic fibrosis pulmonary manifestations. J Cyst Fibros. 2018 Jun 21. pii: S1569-1993(18)30618-0. doi: 10.1016/j.jcf.2018.05.013. [Epub ahead of print] PubMed PMID: 29937318.
  • Thungtong A, Knoch MF, Jacono FJ, Dick TE, Loparo KA. Periodicity: A Characteristic of Heart Rate Variability Modified by the Type of Mechanical Ventilation After Acute Lung Injury. Front Physiol. 2018 Jun 19;9:772. doi: 10.3389/fphys.2018.00772. eCollection 2018. PubMed PMID: 29971020; PubMed Central PMCID: PMC6018479.
  • Litvin DG, Dick TE, Smith CB, Jacono FJLung-injury depresses glutamatergic synaptic transmission in the nucleus tractus solitarii via discrete age-dependent mechanisms in neonatal rats. Brain Behav Immun. 2018 May;70:398-422. doi: 10.1016/j.bbi.2018.03.031. Epub 2018 Mar 28. PubMed PMID: 29601943; PubMed Central PMCID: PMC6075724.
  • Rusu M, Rajiah P, Gilkeson R, Yang M, Donatelli C, Thawani R, Jacono FJ, Linden P, Madabhushi A. Co-registration of pre-operative CT with ex vivo surgically excised ground glass nodules to define spatial extent of invasive adenocarcinoma on in vivo imaging: a proof-of-concept study. Eur Radiol. 2017 Apr 6. doi: 10.1007/s00330-017-4813-0. [Epub ahead of print] PubMed PMID: 28386717.
  • Alilou M, Beig N, Orooji M, Rajiah P, Velcheti V, Rakshit S, Reddy N, Yang M, Jacono F, Gilkeson RC, Linden P, Madabhushi A. An integrated segmentation and shape based classification scheme for distinguishing adenocarcinomas from granulomas on lung CT. Med Phys. 2017 Mar 14. doi: 10.1002/mp.12208. [Epub ahead of print] PubMed PMID: 28295386.
  • Attaway AH, Jacono F, Faress JA. Reply: Pulmonary Aspergillosis in Ankylosing Spondylitis. Am J Respir Crit Care Med. 2016 Nov 15;194(10):1304. PubMed PMID: 27845582.
  • Darrah RJ, Mitchell AL, Campanaro CK, Barbato ES, Litman P, Sattar A, Hodges CA, Drumm ML, Jacono FJEarly pulmonary disease manifestations in cystic fibrosis mice. J Cyst Fibros. 2016 Nov;15(6):736-744. doi: 10.1016/j.jcf.2016.05.002. Epub 2016 May 24. PubMed PMID: 27231029; PubMed Central PMCID: PMC5121081.
  • Attaway AH, Jacono F, Gilkeson R, Faress JA. Subacute Invasive Pulmonary Aspergillosis Associated with Ankylosing Spondylitis. Am J Respir Crit Care Med. 2016 Mar 1;193(5):572-3. doi: 10.1164/rccm.201507-1476IM. PubMed PMID: 26623497.
  • Godard S, Herry C, Westergaard P, Scales N, Brown SM, Burns K, Mehta S, Jacono FJ, Kubelik D, Maziak DE, Marshall J, Martin C, Seely AJ. Practice Variation in Spontaneous Breathing Trial Performance and Reporting. Can Respir J.2016;2016:9848942. doi: 10.1155/2016/9848942. Epub 2016 Mar 29. PubMed PMID: 27445575; PubMed Central PMCID: PMC4904518.
  • Hsieh YH, Jacono FJ, Siegel RE, Dick TE. Respiratory modulation of sympathetic activity is attenuated in adult rats conditioned with chronic hypobaric hypoxia. Respir Physiol Neurobiol. 2015 Jan 15;206:53-60. doi: 10.1016/j.resp.2014.11.011. Epub 2014 Nov 22. PubMed PMID: 25462835; PubMed Central PMCID: PMC4314614.
  • De Georgia MA, Kaffashi F, Jacono FJ, Loparo KA. Information technology in critical care: review of monitoring and data acquisition systems for patient care and research. ScientificWorldJournal. 2015;2015:727694. doi: 10.1155/2015/727694. Epub 2015 Feb 4. Review. PubMed PMID: 25734185; PubMed Central PMCID: PMC4334936.
  • Yamauchi, M, Hasan, O, Dostal, J, Jacono, FJ, Loparo, KA, Strohl, KP. Pharmacologic and Genetic Modification of Post-sigh Breathing Behavior and Spontaneous Pauses in the C57BL/6J (B6) Mouse. Respir Physiol Neurobiol.31;162(2):117-25, 2008.
  • Pawar, A, Peng, Y, Jacono, FJ, Prabhakar, NR. Comparative analysis of neonatal and adult rat carotid body responses to chronic intermittent hypoxia. J Appl Physiol.104(5):1287-94, 2008.
  • Faress, JA, Nethery, D, Kern, E, Eisenberg, R, Jacono, FJ, Allen, C, Kern, JA. Inhibition of human epidermal growth factor receptor 2 (HER2) signaling decreases bleomycin-induced pulmonary fibrosis and improves survival in mice. J Appl Physiol. 103(6):2077-83, 2007.
  • Jacono, FJ, Peng, Y, Nethery, D, Faress, JA, Lee, Z, Kern, JA, Prabhakar, NR. Acute lung injury augments hypoxic ventialtory response in the absence of systemic hypoxemia. J Appl Physiol. 101(6):1795-802, 2006.
  • Peng, Y, Yuan, G, Jacono, FJ, Kumar, GK, Prabhakar, NR. 5-HT evokes sensory long-term facilitation of rodent carotid body via activation of NADPH oxidase. J Physiol. Oct 1; 576(Pt 1):289-95, 2006.
  • Jacono, FJ, Peng, Y, Kumar, GK, Prabhakar, NR. Modulation of the hypoxic sensory response of the carotid body by 5-hydroxytryptamine: Role of the 5-HT2 receptor. Respiratory Physiology & Neurobiology Feb 15;145(2-3):135-42, 2005.


Cleveland FES Center

Medical Director of the Respiratory Therapy Department and Co-chair of the CPR Committee
Louis Stokes Cleveland VA Medical Center

Associate Professor of Medicine, School of Medicine
Case Western Reserve University


Program Contact
Frank Jacono

Contact Number
(216) 844-3201

Contact Email