Andreas Alexopoulos, MD, MPH, is a Staff Physician in the Epilepsy Center of the Neurological Institute, located on the main campus of Cleveland Clinic.

He was appointed in 2005 subsequent to completion of a fellowship in epilepsy and clinical neurophysiology. Prior to his appointment, he was Chief Resident in adult neurology at Mount Sinai School of Medicine, New York City. Dr. Alexopoulos is certified in neurology and in clinical neurophysiology by the American Board of Psychiatry and Neurology, and he is certified in MRI/CT by the American Society of Neuroimaging. His specialty interests include epilepsy, clinical neurophysiology, epilepsy surgery and translational research in epilepsy.

Dr. Alexopoulos received his medical degree from the University of Athens, graduating with honors. He served in the Hellenic navy as a Physician Petty Officer. He returned to the United States for an internship in medicine and surgery at Newton-Wellesley Hospital in Boston, Mass. He is licensed to practice medicine in Massachusetts, Indiana, Ohio, as well as Greece and the United Kingdom.

Publications (Select)

Entire publication list can be found here.

1: Agarwal N, Krishnan B, Burgess RC, Prayson RA, Alexopoulos AV, Gupta A.
Magnetoencephalographic Characteristics of Cortical Dysplasia in Children.
Pediatr Neurol. 2018 Jan;78:13-19. doi: 10.1016/j.pediatrneurol.2017.09.009. Epub
2017 Sep 19. PubMed PMID: 29074057.

2: Jin B, Hu W, Ye L, Krishnan B, Aung T, Jones SE, Najm IM, Alexopoulos AV,
Zhang K, Zhu J, Zhang J, Ding M, Chen Z, Wang S, Wang ZI. Small Lesion Size Is
Associated with Sleep-Related Epilepsy in Focal Cortical Dysplasia Type II. Front
Neurol. 2018 Feb 28;9:106. doi: 10.3389/fneur.2018.00106. eCollection 2018.
PubMed PMID: 29541057; PubMed Central PMCID: PMC5835765.

3: Alkawadri R, Burgess RC, Kakisaka Y, Mosher JC, Alexopoulos AV. Assessment of
the Utility of Ictal Magnetoencephalography in the Localization of the Epileptic
Seizure Onset Zone. JAMA Neurol. 2018 Oct 1;75(10):1264-1272. doi:
10.1001/jamaneurol.2018.1430. PubMed PMID: 29889930; PubMed Central PMCID:

4: El Tahry R, Wang ZI, Thandar A, Podkorytova I, Krishnan B, Tousseyn S, Guiyun
W, Burgess RC, Alexopoulos AV. Magnetoencephalography and ictal SPECT in patients
with failed epilepsy surgery. Clin Neurophysiol. 2018 Aug;129(8):1651-1657. doi:
10.1016/j.clinph.2018.05.010. Epub 2018 Jun 6. PubMed PMID: 29920428.

5: Lin Y, Fang YD, Wu G, Jones SE, Prayson RA, Moosa ANV, Overmyer M, Bena J,
Larvie M, Bingaman W, Gonzalez-Martinez JA, Najm IM, Alexopoulos AV, Wang ZI.
Quantitative positron emission tomography-guided magnetic resonance imaging
postprocessing in magnetic resonance imaging-negative epilepsies. Epilepsia. 2018
Aug;59(8):1583-1594. doi: 10.1111/epi.14474. Epub 2018 Jun 28. PubMed PMID:

6: Wang S, Jin B, Aung T, Katagiri M, Jones SE, Krishnan B, Gonzalez-Martinez JA,
Prayson RA, Najm IM, Alexopoulos AV, Wang S, Ding M, Wang ZI. Application of MRI
Post-processing in Presurgical Evaluation of Non-lesional Cingulate Epilepsy.
Front Neurol. 2018 Nov 27;9:1013. doi: 10.3389/fneur.2018.01013. eCollection
2018. PubMed PMID: 30538671; PubMed Central PMCID: PMC6277515.

7: Wang S, Tang Y, Aung T, Chen C, Katagiri M, Jones SE, Prayson RA, Krishnan B,
Gonzalez-Martinez JA, Burgess RC, Najm IM, Alexopoulos AV, Wang S, Ding M, Wang
ZI. Multimodal noninvasive evaluation in MRI-negative operculoinsular epilepsy. J
Neurosurg. 2019 Apr 12:1-11. doi: 10.3171/2018.12.JNS182746. [Epub ahead of
print] PubMed PMID: 30978689.

8: Wang S, Wang ZI, Tang Y, Alexopoulos AV, Chen C, Katagiri M, Aung T, Najm IM,
Ding M, Wang S, Chauvel P. Localization value of subclinical seizures on scalp
video-EEG in epilepsy presurgical evaluation. Epilepsia. 2019
Dec;60(12):2477-2485. doi: 10.1111/epi.16383. Epub 2019 Nov 21. PubMed PMID:

9: Hirsch LJ, Mirro EA, Salanova V, Witt TC, Drees CN, Brown MG, Lee RW, Sadler
TL, Felton EA, Rutecki P, Shin HW, Hadar E, Hegde M, Rao VR, Mnatsakanyan L,
Madhavan DS, Zakaria TJ, Liu AA, Heck CN, Greenwood JE, Bigelow JK, Nair DR,
Alexopoulos AV, Mackow M, Edwards JC, Sotudeh N, Kuzniecky RI, Gwinn RP, Doherty
MJ, Geller EB, Morrell MJ. Mesial temporal resection following long-term
ambulatory intracranial EEG monitoring with a direct brain-responsive
neurostimulation system. Epilepsia. 2020 Mar;61(3):408-420. doi:
10.1111/epi.16442. Epub 2020 Feb 18. PubMed PMID: 32072621; PubMed Central PMCID:


Cleveland FES Center

Staff Physician, Epilepsy Center
Cleveland Clinic Neurological Institute


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Andreas Alexopoulos, MD, MPH

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