Dr. Lavik’s lab used biomaterials, drug delivery, and tissue engineering approaches to protect and regrow neural tissue. 

Their work spanned from basic work engineering a neural stem cell niche to translatable work delivering off patent drugs in ways that protect and repair the nervous system.

Publications (Select)

  • Tsuneki M, Hardee S, Michaud M, Morotti R, Lavik E, Madri JA. A hydrogel-endothelial cell implant mimics infantile hemangioma: modulation by survivin and the Hippo pathway. Lab Invest. 2015 Jul;95(7):765–780. doi: 10.1038/labinvest.2015.61 Pubmed PMID: 25961170
  • Van Hest J, Lavik EB, Smith BD, Zheng G, Rotello VM. Editorial. Bioconjug Chem. 2015 Feb 18;26(2):163–165. doi: 10.1021/acs.bioconjchem.5b00002 Pubmed PMID: 25588645
  • Lashof-Sullivan MM, Shoffstall E, Atkins KT, Keane N, Bir C, VandeVord P, Lavik EB. Intravenously administered nanoparticles increase survival following blast trauma. Proc Natl Acad Sci USA. 2014 Jul 15;111(28):10293–10298. doi: 10.1073/pnas.1406979111 Pubmed PMID: 24982180
  • Lashof-Sullivan M, Shoffstall A, Lavik E. Intravenous hemostats: challenges in translation to patients. Nanoscale. 2013 Nov 21;5(22):10719–10728. doi: 10.1039/c3nr03595f Pubmed PMID: 24088870
  • Shoffstall AJ, Everhart LM, Varley ME, Soehnlen ES, Shick AM, Ustin JS, Lavik EB. Tuning ligand density on intravenous hemostatic nanoparticles dramatically increases survival following blunt trauma. Biomacromolecules. 2013 Aug 12;14(8):2790–2797. doi: 10.1021/bm400619v Pubmed PMID: 23841817
  • Kador KE, Montero RB, Venugopalan P, Hertz J, Zindell AN, Valenzuela DA, Uddin MS, Lavik EB, Muller KJ, Andreopoulos FM, Goldberg JL. Tissue engineering the retinal ganglion cell nerve fiber layer. Biomaterials. 2013 Jun;34(17):4242–4250. doi: 10.1016/j.biomaterials.2013.02.027 Pubmed PMID: 23489919
  • Shoffstall AJ, Atkins KT, Groynom RE, Varley ME, Everhart LM, Lashof-Sullivan MM, Martyn-Dow B, Butler RS, Ustin JS, Lavik EB. Intravenous hemostatic nanoparticles increase survival following blunt trauma injury. Biomacromolecules. 2012 Nov 12;13(11):3850–3857. doi: 10.1021/bm3013023 Pubmed PMID: 22998772
  • Lavik E, Ustin J. Medicine. Leveraging shear stress to bust clots with nanoparticles. Science. 2012 Aug 10;337(6095):658–659. doi: 10.1126/science.1227097 Pubmed PMID: 22879494
  • Shoffstall AJ, Taylor DM, Lavik EB. Engineering therapies in the CNS: what works and what can be translated. Neurosci Lett. 2012 Jun 25;519(2):147–154. doi: 10.1016/j.neulet.2012.01.058 Pubmed PMID: 22330751
  • Lavik E. Bioengineering approaches to nervous system repair. Neurosci Lett. 2012 Jun 25;519(2):85–86. doi: 10.1016/j.neulet.2012.06.001 Pubmed PMID: 22704082



Cleveland FES Center

Elmer Lindseth Associate Professor of Biomedical Engineering, Department of Biomedical Engineering
Case Western Reserve University