Biomedical Engineering
| Title |
Antidromic Pulse Generating Wave Form for Collision Blocking |
| Description | An electrode cuff (B) including a dielectric sleeve (10) and an annular cathode electrode (20) is disposed around a nerve trunk (A). An anode electrode (22) is disposed in body fluids in electrical communication with the nerve trunk. The cathode electrode is disposed off center within the dielectric sleeve. The flow of electric current from the anode to the cathode has a much greater amplitude along the nerve in the direction extending along the nerve trunk toward the cathode from the end of the dielectric sleeve toward which the cathode electrode is closest. A signal generator (C) applies a pulse train across the anode and cathode electrodes. The pulse train includes a plurality of alternating first amplitude pulse portions (40) and opposite polarity pulse portions (42). Each first polarity pulse includes a sharp leading edge (50) which rises abruptly to a preset amplitude (52). A trailing edge (56) of each first pulse portion decays smoothly into a leading edge (60) of each opposite polarity pulse portion without a discontinuity therebetween. The opposite polarity pulse portion has an amplitude (62) which is smaller than the triggering amplitude and a duration which is longer than the first polarity pulse portion duration. The amplitude and duration of the first and opposite polarity pulse portions are selected such that the.org charge transfer in each direction is substantially the same. |
| FES Center Tracking Code |
(1985-0214) |
| Inventor(s) | Timothy Crish |
| Patent Numbers | 4,649,936; 4,628,942; 4,602,624; 4,608,985 |
| Patent Type | Utility |
| Country of Filing | United States |
| Filing Date | 10/11/1984 |
| Issue Date | 9/2/1986 |
| Title |
Functional Neuromuscular Stimulation System |
| Description | An input command controller (A) provides logic function selection signals and proportional signals. The signals are generated by movement of a ball member (12) and socket member (14) relative to two orthogonal axes. When the joystick is implanted, a transmitter (50) transmits the signals to a patient carried unit (B). The patient carried unit includes an amplitude modulation algorithm such as a look-up table (124), a pulse width modulation algorithm (132), and an interpulse interval modulation algorithm (128). The algorithms derive corresponding stimulus pulse train parameters from the proportional signal which parameters are transmitted to an implanted unit (D). The implanted unit has a power supply (302) that is powered by the carrier frequency of the transmitted signal and stimulation pulse train parameter decoders (314, 316, 318). An output unit (320) assembles pulse trains with the decoded parameters for application to implanted electrodes (E). A laboratory system (C) is periodically connected with the patient carried unit to measure for changes in patient performance and response and reprogram the algorithm accordingly. The laboratory system also performs initial examination, set up, and other functions. |
| FES Center Tracking Code |
(1986-0413) |
| Inventor(s) | James Buckett; P. Peckham; Brian Smith; Geoffrey Thrope |
| Patent Numbers | 5,167,229; 5,776,171; 5,769,875; 6,163,725; 6,026,328; 5,954,758; 6,718,210 |
| Patent Type | Utility; Divisional; Continuation |
| Country of Filing | United States |
| Filing Date | 3/24/86; 7/24/92; 11/15/93; 9/6/94; 6/7/95; 1/20/98; 10/23/00; 11/29/00 |
| Issue Date | 12/1/92; 7/7/98; 6/23/98; 12/19/00; 2/15/00; 9/21/99; 4/6/04 |
| Title |
Intramuscular Electrode for Neuromuscular Stimulation System |
| Description | A helix (10) is defined by two lengths of multistrand wire (14) each surrounded by flexible, biocompatible insulation (18). A silicon elastic sheath (30) surrounds the helix and extends to a terminal end of the electrode. At the terminal end, a portion of the wire is wrapped around a periphery of the sheath to define a tissue contacting surface (34). A shaft (42) of a polypropylene anchor (40) is inserted into a hollow core (20) of the helix and thermally deformed into mechanical engagement with the helix. The anchor has a plurality of polypropylene tines or barbs (44) which firmly engage the tissue within which it is inserted but which yield for electrode removal without ripping the tissue. |
| FES Center Tracking Code |
(1986-0416) |
| Inventor(s) | Michael Keith; William Memberg; P. Peckham |
| Patent Numbers | EP0408358; 4,989,617; 408358 |
| Patent Type | EPC; Utility |
| Country of Filing | Europe; United States; United Kingdom; France; Germany; Italy |
| Filing Date | 7/12/1990 |
| Issue Date | 3/13/96; 2/5/91; 3/13/96 |
| Title |
Slowly Penetrating Interfascicular Nerve Cuff Electrode and Method of Using |
| Description | A self-curling sheet of a non-conductive material is biased to curl into a tight cylinder. Inwardly extending conductive members are disposed on the surface of the sheet forming the inside of the cylinder. Circumferentially separated longitudinal slices are made in the cylinder adjacent the conductive members forming spring members such that, as the sheet relaxes over time, the electrodes on the spring members engage and pierce a nerve surrounded by the cuff. The conductive segments may be electrically conductive for applying electrical impulses or fluid conductive for infusing medications. In use, a first edge of the self-curling sheet is disposed adjacent a nerve trunk which is to receive the cuff therearound. The self-curling sheet is controllably permitted to curl around the nerve into its original cylindrical shape. Over a period of a few days, electrodes riding on spring members formed by longitudinal slices into the cylinder are embedded in the nerve without damage to the perineurium membrane surrounding the nerve axons. The electrodes displace the fascicles rather than damaging them by piercing the perineurium. |
| FES Center Tracking Code |
(1993-0108) |
| Inventor(s) | Dustin Tyler |
| Patent Numbers | 5,400,784; 5,634,462 |
| Patent Type | Utility; Continuation-in-Part; Continuation; PCT |
| Country of Filing | United States |
| Filing Date | 10/13/94; 3/27/95; 5/30/97 |
| Issue Date | 10/13/94; 3/27/95; 5/30/97 |
| Title |
Event-scheduling algorithm for functional electrical stimulation |
| Description | |
| FES Center Tracking Code |
2000-0869 |
| Inventor(s) | James Buckett |
| Patent Numbers | |
| Patent Type | Provisional |
| Country of Filing | United States |
| Filing Date | 11/12/2001 |
| Issue Date |
| Title |
Waveforms for Selective Stimulations of Central Nervous System Neurons |
| Description | Asymmetric charge-balanced stimulation waveforms are defined and used for CNS stimulation with selective stimulation of either neuronal cell bodies or axon fibers of passage in favor of the other. A pre-pulse is followed by an opposite polarity stimulation pulse, with the pre-pulse being relatively low-amplitude and long-duration as compared to the stimulation pulse. The pre-pulse and stimulation pulse are charge-balanced to prevent tissue damage and electrode corrosion. The polarity of the pre-pulse and stimulation pulse control the selectivity of stimulation with respect to neuronal cell bodies versus axon fibers of passage. The waveform used in the stimulation method optionally includes a zero-amplitude phase having a duration of 0 to 500 microseconds. |
| FES Center Tracking Code |
2001-0508 |
| Inventor(s) | Cameron McIntyre |
| Patent Numbers | 6,560,490 |
| Patent Type | Utility; Provisional |
| Country of Filing | United States |
| Filing Date | 3/5/01; 9/26/00 |
| Issue Date | 06/05/2003 |
| Title |
Systems and Methods for Reversibly Blocking Nerve Activity |
| Description | Systems and methods for blocking nerve impulses use an implanted electrode located on or around a nerve. A specific waveform is used that causes the nerve membrane to become incapable of transmitting an action potential. The membrane is only affected underneath the electrode, and the effect is immediately and completely reversible. The waveform has a low amplitude and can be charge balanced, with a high likelihood of being safe to the nerve for chronic conditions. It is possible to selectively block larger (motor) nerve fibers within a mixed nerve, while allowing sensory information to travel through unaffected nerve fibers. |
| FES Center Tracking Code |
2001-0671 |
| Inventor(s) | Kevin Kilgore; Cameron McIntyre |
| Patent Numbers | 7,389,145; US 80,602,08 |
| Patent Type | PCT; Utility; Continuation-in-Part; Reissue; Provisional |
| Country of Filing | Canada; Australia; United States |
| Filing Date | 2/20/02; 2/17/04; 6/17/08; 6/16/10; 2/21/01 |
| Issue Date | 6/17/08; 11/15/11 |
| Title |
Systems and Methods for Selectively Stimulating Components In, On, or Near the Pudendal Nerve or its Branches to Achieve Selective Physiologic Responses |
| Description | Systems and methods selectively stimulate components of the pudendal nerve away from the sacral root to evoke desired physiologic responses in persons who lack the ability to otherwise produce these responses–e.g., maintain continence and/or produce micturition, and/or provide male/female sexuality responses, and/or provide bowel responses. The systems and methods use a multiple electrode array, or individual electrodes, placed on, in, or near the pudendal nerve. The electrode array, or individual electrodes, in association with a pulse generator, provide selective stimulation of individual fascicles within the pudendal nerve, to achieve different physiologic responses. |
| FES Center Tracking Code |
2001-0678 |
| Inventor(s) | Kenneth Gustafson |
| Patent Numbers | 2002 247449; 2007200136; 6,907,293; 7,047,078; 7,623,925; US 7,571,000 B2 |
| Patent Type | EPC; PCT; Continuation-in-Part; Divisional; Utility |
| Country of Filing | Canada; Europe; Australia; United States; Japan; Hong Kong |
| Filing Date | 9/22/06; 3/29/02; 7/7/04; 8/26/10; 1/12/07; 9/12/03; 5/31/05; 4/11/06; 6/24/09; 10/15/09; 9/29/03; 3/30/01; 9/1/04 |
| Issue Date | 2/1/07; 6/14/05; 5/16/06; 11/24/09; 8/4/09 |
| Title |
Networked Implantable Neuroprosthesis |
| Description | A neural prosthesis includes a centralized device that can provide power, data, and clock signals to one or more individual neural prosthesis subsystems. Each subsystem may include a number of individually addressable, programmable modules that can be dynamically allocated or shared among neural prosthetic networks to achieve complex, coordinated functions or to operate in autonomous groups. |
| FES Center Tracking Code |
2002-0579 |
| Inventor(s) | Timothy Crish; Kevin Kilgore; P. Peckham |
| Patent Numbers | 7,260,436 |
| Patent Type | Utility; Divisional; Provisional; PCT |
| Country of Filing | United States |
| Filing Date | 10/16/02; 8/21/07; 10/16/01 |
| Issue Date | 21/08/2007 |
| Title |
Method for Activation of Urethral Sensory Nerves |
| Description | |
| FES Center Tracking Code |
2002-0648 |
| Inventor(s) | Kenneth Gustafson |
| Patent Numbers | |
| Patent Type | Provisional |
| Country of Filing | United States |
| Filing Date | 16/10/2001 |
| Issue Date | 6/17/08; 11/15/11 |
| Title |
Flat Interface Nerve Electrode |
| Description | A flat interface nerve electrode is provided along with a method for its use. The electrode provides a plurality of conductive elements embedded in a non-conductive cuff structure, which acts to gently and non-evasively redefine the geometry of a nerve through the application of a force so as to apply pressure to a nerve in a defined range, namely from 2 to 40 mmHG and more preferably from 15 to 30 mmHG and most preferably from 15 mmHG to 20 MMHG. This range is selected to minimize the reduction of blood flow within the tissue, which preferably is at least 70% of the initial value, more preferably 90% of the initial value. The cuff has an opening, which is elongated relative to the diameter of the nerve to which it is applied. Preferably, the cuff is constructed from an elastic bio-compatible material having top and bottom beam members configured to define a nerve opening. The cuff is open at one side and has a connection at the other side which results in a spring force being applied through the surfaces of the nerve opening to the subject nerve. During implantation the open sides of the cuff are closed so as to capture the nerve in the cuff. As the nerve is reshaped, specific nerve axons become more easily addressed through the epineurium by the embedded conductive elements. |
| FES Center Tracking Code |
2005-1034 |
| Inventor(s) | Dustin Tyler |
| Patent Numbers | 6,456,866 |
| Patent Type | Utility |
| Country of Filing | United States |
| Filing Date | 28/09/1999 |
| Issue Date | 24/09/2002 |
| Title |
Flat Interface Nerve Electrode Double-Ended Closure Mechanism |
| Description | |
| FES Center Tracking Code |
2005-1036 |
| Inventor(s) | Dustin Tyler |
| Patent Numbers | |
| Patent Type | Utility; Provisional |
| Country of Filing | United States |
| Filing Date | 8/15/07; 8/15/06 |
| Issue Date | 21/08/2007 |
| Title |
Electrical Nerve Conduction Block with Reduced Onset Response |
| Description | |
| FES Center Tracking Code |
2005-1095 |
| Inventor(s) | Niloy Bhadra; Kevin Kilgore |
| Patent Numbers | |
| Patent Type | Utility; Foreign Filing; Provisional; PCT |
| Country of Filing | Canada; Europe; Australia; United States; Japan |
| Filing Date | 10/28/08; 9/28/08; 4/23/10; 10/29/07 |
| Issue Date |
| Title |
Contralaterally Controlled Neuromuscular Stimulator for Therapy in Post-Stroke Hemiplegia |
| Description | A system for neuromuscular electrical stimulation therapy includes one or more sensors for sensing the position or the muscle contractions of a body part, such as an arm, hand, finger, leg, etc.; a stimulator in communication with the sensor or sensors; and two or more electrodes that can be positioned to activate the paralyzed body part. Based on signals from the one or more sensors, the stimulator can regulate the stimulation provided through the electrodes, including the intensity and duration of the electrical stimulation signal. The sensors can be assembled in a wearable article, such as a glove, sock, or sleeve, to monitor the position or muscle contractions of the healthy body part. The electrodes also may be assembled in a wearable device that allows customized placement of those electrodes. |
| FES Center Tracking Code |
2006-1174 |
| Inventor(s) | John Chae; Jayme Knutson; P. Peckham |
| Patent Numbers | US 8,165,685 |
| Patent Type | Utility; Provisional |
| Country of Filing | United States |
| Filing Date | 9/28/06; 9/29/05 |
| Issue Date |
| Title |
Control of a Neuroprosthesis with EMG Activity from Clinically Paralyzed Muscles in Complete Spinal Cord Injury |
| Description | |
| FES Center Tracking Code |
2008-1539 |
| Inventor(s) | P. Peckham |
| Patent Numbers | |
| Patent Type | National Filing; Provisional; PCT |
| Country of Filing | United States |
| Filing Date | 7/29/10; 1/30/08; 1/30/09 |
| Issue Date |
| Title |
Stimulus-Responsive, Mechanically-Dynamic Nanocomposites |
| Description | |
| FES Center Tracking Code |
2008-1588 |
| Inventor(s) | Dustin Tyler |
| Patent Numbers | |
| Patent Type | Utility; Provisional |
| Country of Filing | United States |
| Filing Date | 08/04/2009 |
| Issue Date |
| Title |
Hybrid System for Laryngeal Control with Detection of Physiologically Relevant Control Signals |
| Description | |
| FES Center Tracking Code |
2009-1679 |
| Inventor(s) | Dustin Tyler |
| Patent Numbers | |
| Patent Type | Utility; Provisional |
| Country of Filing | United States |
| Filing Date | 18/11/2010 |
| Issue Date |
| Title |
Adjustable Electrode for High Frequency Alternating Current Block |
| Description | |
| FES Center Tracking Code |
2009-1702 |
| Inventor(s) | Niloy Bhadra; Kevin Kilgore |
| Patent Numbers | |
| Patent Type | Utility; Provisional |
| Country of Filing | United States |
| Filing Date | 11/18/10; 11/23/09 |
| Issue Date |
| Title |
A System and Method of Blocking Peripheral Nerves Without Onset Response Using a Combined Nerve Cooling and High Frequency Current Delivery |
| Description | |
| FES Center Tracking Code |
2010-1798 |
| Inventor(s) | Niloy Bhadra; Kevin Kilgore |
| Patent Numbers | |
| Patent Type | Provisional |
| Country of Filing | United States |
| Filing Date | 23/11/2009 |
| Issue Date |
| Title |
An Electrode and Method of Using Same for Delivering Prolonged Single Phase Currents to Nerve |
| Description | |
| FES Center Tracking Code |
2010-1799 |
| Inventor(s) | Narendra Bhadra; Niloy Bhadra; Kevin Kilgore |
| Patent Numbers | |
| Patent Type | Utility; Provisional |
| Country of Filing | United States |
| Filing Date | 11/18/10; 11/23/09 |
| Issue Date |
| Title |
Routes of Administration and Application of Synthetic Platelets |
| Description | |
| FES Center Tracking Code |
2010-1937 |
| Inventor(s) | Erin Lavik; Jeff Ustin |
| Patent Numbers | |
| Patent Type | Provisional |
| Country of Filing | United States |
| Filing Date | 13/10/2011 |
| Issue Date |
| Title |
Extended And Sustained Delivery Of Therapeutic Agents In The Eyes |
| Description | |
| FES Center Tracking Code |
2011-2024 |
| Inventor(s) | Erin Lavik |
| Patent Numbers | |
| Patent Type | Provisional; PCT |
| Country of Filing | United States |
| Filing Date | 10/18/10; 10/18/11 |
| Issue Date |
| Title |
Increasing Functional Capability of Clinical Peripheral Nerve Interfaces |
| Description | |
| FES Center Tracking Code |
2011-2062 |
| Inventor(s) | Dustin Tyler |
| Patent Numbers | |
| Patent Type | Provisional |
| Country of Filing | United States |
| Filing Date | 25/04/2011 |
| Issue Date |
| Title |
Methods of Treatment of a Neurological Disorder Using Electrical Nerve Conduction Block |
| Description | |
| FES Center Tracking Code |
CWR-021435 US CIP 1 |
| Inventor(s) | Niloy Bhadra, Narendra Bhadra, Kevin L. Kilgore, Scott Lempka, Jesse Wainright, Tina Vrabec, Manfred Franke |
| Patent Numbers | |
| Patent Type | Utility; |
| Country of Filing | United States |
| Filing Date | 2015/12/15 |
| Issue Date |
| Title |
Systems and Methods for Preventing Noise in an Electric Waveform for Neural Stimulation, Block, or Sensing |
| Description | One aspect of the present disclosure relates to a system that can prevent unintended signal components (noise) in an electric waveform that can be used for at least one of neural stimulation, block, and/or sensing. The system can include a signal generator to generate a waveform that includes an intended electric waveform and unintended noise. The system can also include a signal transformer device (e.g., a very long wire) comprising a first coil and a second coil. The first coil can be coupled to the signal generator to receive the waveform and remove the unintended noise from the electric waveform. The second coil can pass the electric waveform to an electrode. The second coil can be coupled to a capacitor that can prevent the waveform from developing noise at an electrode/electrolyte interface between an electrode and a nerve. |
| FES Center Tracking Code |
CWR-023129 US CIP 1 |
| Inventor(s) | Manfred Franke |
| Patent Numbers | |
| Patent Type | Utility; Utility; Provisional |
| Country of Filing | United States |
| Filing Date | 2015/05/08; 2014/05/12; 2013/05/10 |
| Issue Date |
| Title |
Systems and methods for removing contaminating noise from an electric waveform for neural stimulation and nerve block |
| Description | One aspect of the present disclosure relates to a system that can remove contaminating noise (e.g., direct current (DC) contamination or high frequency contamination) from an electric waveform. The system can include a passive filter that includes at least a secondary-side-open-transformer-inductor (SOTI). The SOTI can include a first coil inductively coupled to a second coil. The first coil of the SOTI can receive the electric waveform contaminated with the noise and output the electric waveform. The second coil of the SOTI can provide an impedance that facilitates removal of the noise from the electric waveform. |
| FES Center Tracking Code |
CWR-022220 US ORD |
| Inventor(s) | Manfred Franke |
| Patent Numbers | US 9,205,265 |
| Patent Type | Utility; Provisional |
| Country of Filing | United States |
| Filing Date | 2014/05/12; 2013/05/10 |
| Issue Date | 2015/12/08 |
| Title |
Systems and Methods for Temporary, Incomplete, Bi-Directional, Adjustable Electrical Nerve Block |
| Description | One aspect of the present disclosure relates to a system that can provide an incomplete nerve block to a patient. In some instances, the incomplete nerve block can be bi-directional. In other instances, the incomplete nerve block can be adjustable. The system can include a waveform generator that can provide temporary electrical nerve conduction block to a nerve using an electrode. The electrode can include at least one contact. The temporary electrical nerve conduction block can block conduction in less than 100% of the fibers within the nerve located in close proximity to or being surrounded by the electrode. The temporary electrical nerve conduction block does not cause intentional damage to neural tissue as mode of action to achieve the incomplete nerve block. A complete recovery of nerve conduction can be expected post application of the incomplete nerve block. |
| FES Center Tracking Code |
CWR-022332 US ORD |
| Inventor(s) | Manfred Franke, Ashritha Epur, Benjamin Kaufman |
| Patent Numbers | |
| Patent Type | Utility; Provisional |
| Country of Filing | United States |
| Filing Date | 2014/04/30; 2013/04/30 |
| Issue Date |
| Title |
Systems and Methods that Provide an Electrical Waveform for Neural Stimulation or Nerve Block |
| Description | One aspect of the present disclosure relates to a system that can provide an electric waveform for neural stimulation or nerve block. The system can include a first circuit component configured to provide a self-oscillating, voltage-boosted electric waveform. In some instances, the first circuit component can provide a “pause” waveform (e.g., with a period (T) that includes a swing time (ts) in which the waveform varies in a biphasic manner and a pause time (tp) in which the waveform has a constant amplitude). The system can also include a second circuit component configured to ensure that the oscillating signal is charge-balanced across at least one period of the self-oscillating, voltage-boosted electric waveform. |
| FES Center Tracking Code |
CWR-022357 US CON 1 |
| Inventor(s) | Manfred Franke, Kevin L. Kilgore, Niloy Bhadra |
| Patent Numbers | |
| Patent Type | Utility; Provisional |
| Country of Filing | United States |
| Filing Date | 9/28/06; 9/29/05 |
| Issue Date |
| Title |
Systems and Methods that Provide an Electrical Waveform for Neural Stimulation or Nerve Block |
| Description | One aspect of the present disclosure relates to a system that can provide an electric waveform for neural stimulation or nerve block. The system can include a first circuit component configured to provide a self-oscillating, voltage-boosted electric waveform. In some instances, the first circuit component can provide a “pause” waveform (e.g., with a period (T) that includes a swing time (ts) in which the waveform varies in a biphasic manner and a pause time (tp) in which the waveform has a constant amplitude). The system can also include a second circuit component configured to ensure that the oscillating signal is charge-balanced across at least one period of the self-oscillating, voltage-boosted electric waveform. |
| FES Center Tracking Code |
CWR-022357 US ORD |
| Inventor(s) | Manfred Franke, Kevin L. Kilgore, Niloy Bhadra |
| Patent Numbers | US 9,119,966 |
| Patent Type | Utility; Provisional; Provisional |
| Country of Filing | United States |
| Filing Date | 2014/05/12; 2013/05/17; 2013/05/10 |
| Issue Date | 2015/09/01 |
| Title |
Therapy Delivery Devices and Methods for Non-Damaging Neural Tissue Conduction Block |
| Description | Devices and methods for blocking signal transmission through neural tissue. One step of a method includes placing a therapy delivery device into electrical communication with the neural tissue. The therapy delivery device includes an electrode contact having a high charge capacity material. A multi-phase direct current (DC) can be applied to the neural tissue without damaging the neural tissue. The multi-phase DC includes a cathodic DC phase and anodic DC phase that collectively produce a neural block and reduce the charge delivered by the therapy delivery device. The DC delivery can be combined with high frequency alternating current (HFAC) block to produce a system that provides effective, safe, long tem block without inducing an onset response. |
| FES Center Tracking Code |
CWR-021435 US PCT |
| Inventor(s) | Niloy Bhadra, Kevin L. Kilgore, Narendra Bhadra, Jesse Wainright, Tina Vrabec, Manfred Franke |
| Patent Numbers | To be assigned soon; patent allowed on 2016/03/15. |
| Patent Type | Provisional; Provisional; Utility; PCT; EP; CA; JP; AU |
| Country of Filing | United States; EU; Canada; Japan; Australia |
| Filing Date | 2013/05/10; 2013/06/14; 2014/12/15; 2014/02/19; 2014/12/10; 2014/12/12; 2015/01/22 |
| Issue Date |