Alberts, Jay, PhD

The aim of my research is to understand structure-function relationships within the central nervous system and the upper extremity.

Our goal is to understand the complex interactions involved in the systems-level neural organization and control of bladder and urethral function. We use this information to develop neural prostheses or rehabilitative techniques that interface with the nervous system and restore genito-urinary function at the earliest opportunity.

My research focuses on determining how grasping forces and torques are controlled and coordinated during functional dexterous manipulations. Investigation of movement patterns produced by different patient groups and healthy adults provides a window into the brain with respect to the control of voluntary movement.

We work with Parkinson’s disease (PD) patients to determine the role of the basal ganglia in movement control. Recently, we have shown that unilateral deep brain stimulation provides long-term bilateral motor benefits. We are also comparing the effects of assisted vs. voluntary exercise on PD motor function.

These studies suggest that central motor control processing may be improved by “assisted exercise” (e.g., a patient’s “passive” leg movements being generated by the pedaling of a healthy partnering cyclist on a tandem bicycle). Studies comparing motor performance in old vs. young adults reveal the effects of normal aging on motor function. We have shown that older adults have specific impairments in the release of grasping forces, which may contribute to diminished hand function. Overall, these data provide insight into mechanisms underlying upper-extremity motor function. These investigations have the potential to improve clinical practice through better methods of motor assessment.

The objective, quantitative assessment of motor function will aid in disease diagnostic capability and specificity, slowing of disease progression and intervention efficacy for patients in which movement is compromised.

Research Programs

• Deep Brain Stimulation and Motor Function in Parkinson’s Patients

Publications (Select)

Entire publication list can be found here.