Research is an evolutionary process that depends on a complementary relationship between discovery and application. The fundamental exploration into mechanisms, models and methods provides the fuel with which technology is developed and clinical solutions applied. Conversely, as a solution is applied, new and different questions arise that feed additional exploration. Programs within the Cleveland FES Center examine problems in neural interfacing, modeling of systems, material and electrode development, human motor control and motor learning, and fundamental studies. The FES Center searches out new expertise and technologies to incorporate into it’s existing portfolio and trains new investigators and clinicians. These endeavors are critical to the future success of the clinical applications. Fundamental and clinical research efforts within the FES Center are highly synergistic and coexist naturally under one programmatic umbrella. The unique collaboration and interdisciplinary exchange that takes place has catalyzed our past successes and is the foundation upon which our future is built.