Electrical activation of the paralyzed neuromuscular system (functional electrical stimulation-FES) provides a means for restoration of control of the paralyzed extremities.

My research involves the development of neuroprostheses that use FES to restore hand/arm control to individuals of cervical level spinal cord injury (quadriplegia).

Areas of Interest

  • FES systems for control of the extremity including acquisition of myoelectric control information, activation and coordination of multiple muscles to produce synthesized movement, and sensory feedback.
  • Implantable FES systems including sensors, telemetry, stimulators and electrodes.
  • Evaluation of neuroprostheses supplying upper extremity function in human subjects.

Research Programs

  • Implantable FES for Control of the Extremities in Spinal Cord Injury, Department of Veterans Affairs
  • Multichannel Implantable System for Neural Control, National Institutes of Health
  • Development of Networked Implantable Neuroprosthesis, National Institutes of Health
  • Biomedical Research and Technology Transfer Partnership Award, Neurostimulation and Neuromodulation Partnership, State of Ohio
  • Restoration of Hand-Arm Function with Neuroprostheses
  • Cleveland Center of Excellence in Functional Electrical Stimulation
  • Implanted Myoelectric Control for Restoration of Hand Function in SCI

Co-Investigator Programs

  • Restoration of Hand and Arm Function by Functional Neuromuscular Stimulation, National Institutes of Health

Publications (Select)

Entire publication list can be found here.

  • Menezes IS, Cohen LG, Mello EA, Machado AG, Peckham PH, Anjos SM, Siqueira IL, Conti J, Plow EB, Conforto AB. Combined Brain and Peripheral Nerve Stimulation in Chronic Stroke Patients With Moderate to Severe Motor Impairment. Neuromodulation. 2018 Feb;21(2):176–183. doi: 10.1111/ner.12717 Pubmed PMID: 29067749
  • Kilgore KL, Bryden A, Keith MW, Hoyen HA, Hart RL, Nemunaitis GA, Peckham PH. Evolution of Neuroprosthetic Approaches to Restoration of Upper Extremity Function in Spinal Cord Injury. Top Spinal Cord Inj Rehabil. 2018 Summer;24(3):252–264. doi: 10.1310/sci2403-252 Pubmed PMID: 29997428
  • Ilfeld BM, Gabriel RA, Saulino MF, Chae J, Peckham PH, Grant SA, Gilmore CA, Donohue MC, deBock MG, Wongsarnpigoon A, Boggs JW. Infection Rates of Electrical Leads Used for Percutaneous Neurostimulation of the Peripheral Nervous System. Pain Pract. 2017 Jul;17(6):753–762. doi: 10.1111/papr.12523 Pubmed PMID: 27676323
  • Heald E, Hart R, Kilgore K, Peckham PH. Characterization of Volitional Electromyographic Signals in the Lower Extremity After Motor Complete Spinal Cord Injury. Neurorehabil Neural Repair. 2017 Jun;31(6):583-591. doi: 10.1177/1545968317704904. Epub 2017 Apr 26. PubMed PMID: 28443786.
  • Ajiboye AB, Willett FR, Young DR, Memberg WD, Murphy BA, Miller JP, Walter BL, Sweet JA, Hoyen HA, Keith MW, Peckham PH, Simeral JD, Donoghue JP, Hochberg LR, Kirsch RF. Restoration of reaching and grasping movements through brain-controlled muscle stimulation in a person with tetraplegia: a proof-of-concept demonstration. Lancet. 2017 May 6;389(10081):1821-1830. doi: 10.1016/S0140-6736(17)30601-3. Epub 2017 Mar 28. PubMed PMID: 28363483.
  • Ilfeld BM, Gabriel RA, Saulino MF, Chae J, Peckham PH, Grant SA, Gilmore CA, Donohue MC, deBock MG, Wongsarnpigoon A, Boggs JW. Infection Rates of Electrical Leads Used for Percutaneous Neurostimulation of the Peripheral Nervous System. Pain Pract. 2016 Sep 27. doi: 10.1111/papr.12523. [Epub ahead of print] PubMed PMID: 27676323; PubMed Central PMCID: PMC5368033.
  • Bowsher K, Civillico EF, Coburn J, Collinger J, Contreras-Vidal JL, Denison T, Donoghue J, French J, Getzoff N, Hochberg LR, Hoffmann M, Judy J, Kleitman N, Knaack G, Krauthamer V, Ludwig K, Moynahan M, Pancrazio JJ, Peckham PH, Pena C, Pinto V, Ryan T, Saha D, Scharen H, Shermer S, Skodacek K, Takmakov P, Tyler D, Vasudevan S, Wachrathit K, Weber D, Welle CG, Ye M. Brain-computer interface devices for patients with paralysis and amputation: a meeting report. J Neural Eng. 2016 Apr;13(2):023001. doi: 10.1088/1741-2560/13/2/023001. Epub 2016 Feb 29. PubMed PMID: 26924826.
  • Ommaya AK, Adams KM, Allman RM, Collins EG, Cooper RA, Dixon CE, Fishman PS, Henry JA, Kavrdon R, Kerns RD, Kupersmith J, Lo A, Macko R, McArdle R, McGlinchey RE, McNeil MR, O’Toole TP, Peckham PH, Tuszynski MH, Waxman SG, Wittenberg GF. Guest Editorial: Opportunities in rehabilitation research. J Rehabil Res Dev. 2013 Sep;50(6):vii-xxxii. doi: 10.1682/JRRD.2012.09.0167. PubMed PMID: 24203548.
  • Peckham PH, Kilgore KL. Challenges and opportunities in restoring function after paralysis. IEEE Trans Biomed Eng. 2013 Mar;60(3):602-9. doi: 10.1109/TBME.2013.2245128. Epub 2013 Mar 7. PubMed PMID: 23481680.
  • Knutson JS, Chae J, Hart RL, Keith MW, Hoyen HA, Harley MY, Hisel TZ, Bryden AM, Kilgore KL, Peckham H. Implanted neuroprosthesis for assisting arm and hand function after stroke: a case study. J Rehabil Res Dev. 2012;49(10):1505-16. PubMed PMID: 23516054; PubMed Central PMCID: PMC3605749.
  • Hart RL, Bhadra N, Montague FW, Kilgore KL, Peckham PH. Design and testing of an advanced implantable neuroprosthesis with myoelectric control. IEEE Trans Neural Syst Rehabil Eng. 2011 Feb;19(1):45-53. doi: 10.1109/TNSRE.2010.2079952. Epub 2010 Sep 27. PubMed PMID: 20876029.
  • Moss CW, Kilgore KL, Peckham PH. A novel command signal for motor neuroprosthetic control. Neurorehabil Neural Repair. 2011 Nov-Dec;25(9):847-54. doi: 10.1177/1545968311410067. Epub 2011 Jun 21. PubMed PMID: 21693772.

PROFESSIONAL AFFILIATIONS

Investigator
Cleveland FES Center

Distinguished University Professor, Donnell Institute Professor of Biomedical Engineering
Case Western Reserve University

Professor of Biomedical Engineering, and Professor of Orthopaedics, Institute for Functional Restoration, School of Medicine
Case Western Reserve University

Founder, Institute for Functional Restoration, School of Medicine
Case Western Reserve University

Senior Research Career Scientist, and Biomedical Engineer
Louis Stokes Cleveland VA Medical Center

Co-Director, MetroHealth Rehabilitation Institute
MetroHealth Medical Center

CONTACT INFORMATION

Program Contact
Laura Polacek

Contact Number
(216) 957-3368

Contact Email
lkp3@case.edu, pxp2@case.edu