Mapping the epileptogenic zone as well as epileptic and functional brain networks is a cornerstone principle in guiding therapeutics for patients with medically intractable epilepsy.
Accurate identification of these regions is necessary to achieve seizure freedom and avoiding functional deficits. We believe that mapping of these regions will be informed principally by clinical neurophysiologic data as well as other data points including: seizure semiology, neuroimaging, nuclear imaging, cognitive neuroscience, and neuropathology.
Therefore, we aim to:
1. Develop clinical neurophysiologic markers of the epileptogenic zone and epileptic network
2. Develop clinical neurophysiologic markers of functional networks in the brain
3. Attempt to modulate the epileptic network through use of direct cortical and subcortical electrical stimulation
Publications (Select)
Entire publication list can be found here.
- Grinenko O, Li J, Mosher JC, Wang IZ, Bulacio JC, Gonzalez-Martinez J, Nair D, Najm I, Leahy RM, Chauvel P. A fingerprint of the epileptogenic zone in human epilepsies. Brain. 2018 Jan 1;141(1):117–131. doi: 10.1093/brain/awx306 Pubmed PMID: 29253102
- Grinenko O, Li J, Mosher JC, Wang IZ, Bulacio JC, Gonzalez-Martinez J, Nair D, Najm I, Leahy RM, Chauvel P. A fingerprint of the epileptogenic zone in human epilepsies. Brain. 2017 Dec 14; doi: 10.1093/brain/awx306 Pubmed PMID: 29253102
- Halford JJ, Sperling MR, Nair DR, Dlugos DJ, Tatum WO, Harvey J, French JA, Pollard JR, Faught E, Noe KH, Henry TR, Jetter GM, Lie OV, Morgan LC, Girouard MR, Cardenas DP, Whitmire LE, Cavazos JE. Detection of generalized tonic-clonic seizures using surface electromyographic monitoring. Epilepsia. 2017 Nov;58(11):1861–1869. doi: 10.1111/epi.13897 Pubmed PMID: 28980702
- El Tahry R, Krishnan B, Wang ZI, Nair D, Alexopoulos A. Unexpected increase of seizures in a patient treated with responsive neurostimulation: Check the lead! Clin Neurophysiol. 2017 Oct;128(10):1821–1822. doi: 10.1016/j.clinph.2017.07.001 Pubmed PMID: 28822301 Tousseyn S, Krishnan B, Wang ZI, Wongwiangjunt S, Nayak CS, Mosher JC, Wu G, Van Paesschen W, Leahy RM, Gonzalez-Martinez JA, Bulacio J, Najm IM, Alexopoulos AV, Nair DR. Connectivity in ictal single photon emission computed tomography perfusion: a cortico-cortical evoked potential study. Brain. 2017 Jul 1;140(7):1872–1884. doi: 10.1093/brain/awx123 Pubmed PMID: 28582473
- Jobst BC, Kapur R, Barkley GL, Bazil CW, Berg MJ, Bergey GK, Boggs JG, Cash SS, Cole AJ, Duchowny MS, Duckrow RB, Edwards JC, Eisenschenk S, Fessler AJ, Fountain NB, Geller EB, Goldman AM, Goodman RR, Gross RE, Gwinn RP, Heck C, Herekar AA, Hirsch LJ, King-Stephens D, Labar DR, Marsh WR, Meador KJ, Miller I, Mizrahi EM, Murro AM, Nair DR, Noe KH, Olejniczak PW, Park YD, Rutecki P, Salanova V, Sheth RD, Skidmore C, Smith MC, Spencer DC, Srinivasan S, Tatum W, Van Ness P, Vossler DG, Wharen REJ, Worrell GA, Yoshor D, Zimmerman RS, Skarpaas TL, Morrell MJ. Brain-responsive neurostimulation in patients with medically intractable seizures arising from eloquent and other neocortical areas. Epilepsia. 2017 Jun;58(6):1005–1014. doi: 10.1111/epi.13739 Pubmed PMID: 28387951
- Geller EB, Skarpaas TL, Gross RE, Goodman RR, Barkley GL, Bazil CW, Berg MJ, Bergey GK, Cash SS, Cole AJ, Duckrow RB, Edwards JC, Eisenschenk S, Fessler J, Fountain NB, Goldman AM, Gwinn RP, Heck C, Herekar A, Hirsch LJ, Jobst BC, King-Stephens D, Labar DR, Leiphart JW, Marsh WR, Meador KJ, Mizrahi EM, Murro AM, Nair DR, Noe KH, Park YD, Rutecki PA, Salanova V, Sheth RD, Shields DC, Skidmore C, Smith MC, Spencer DC, Srinivasan S, Tatum W, Van Ness PC, Vossler DG, Wharen REJ, Worrell GA, Yoshor D, Zimmerman RS, Cicora K, Sun FT, Morrell MJ. Brain-responsive neurostimulation in patients with medically intractable mesial temporal lobe epilepsy. Epilepsia. 2017 Jun;58(6):994–1004. doi: 10.1111/epi.13740 Pubmed PMID: 28398014
- Matsumoto R, Kunieda T, Nair D. Single pulse electrical stimulation to probe functional and pathological connectivity in epilepsy. Seizure. 2017 Jan;44:27–36. doi: 10.1016/j.seizure.2016.11.003 Pubmed PMID: 27939100
PROFESSIONAL AFFILIATIONS
Investigator
Cleveland FES Center
Neurologist, Epilepsy Center, Neurological Institute
Cleveland Clinic
CONTACT INFORMATION
Program Contact
Dileep Nair
Contact Number
(216) 444-5050
Contact Email
naird@ccf.org