Dr. Lhatoo’s clinical and research interests are the investigation and management of refractory epilepsy; mortality of epilepsy with particular regard to sudden death in epilepsy (SUDEP)

Publications (Select)

  • Jamal-Omidi S, Collins C, Fulchiero E, Liu H, Colon-Zimmermann K, Fuentes-Casiano E, Tatsuoka C, Cassidy KA, Lhatoo S, Sajatovic M. Assessing depression severity with a self-rated vs. rater-administered instrument in patients with epilepsy. Epilepsy Behav. 2018 Aug;85:52-57. doi: 10.1016/j.yebeh.2018.05.018. Epub 2018 Jun 13. PubMed PMID: 29908384.
  • Kaddumukasa M, Kaddumukasa MN, Buwembo W, Munabi IG, Blixen C, Lhatoo S, Sewankambo N, Katabira E, Sajatovic M. Epilepsy misconceptions and stigma reduction interventions in sub-Saharan Africa, a systematic review. Epilepsy Behav. 2018 Aug;85:21-27. doi: 10.1016/j.yebeh.2018.04.014. Epub 2018 Jun 13. Review. PubMed PMID: 29906697.
  • Murugesan A, Rani MRS, Hampson J, Zonjy B, Lacuey N, Faingold CL, Friedman D, Devinsky O, Sainju RK, Schuele S, Diehl B, Nei M, Harper RM, Bateman LM, Richerson G, Lhatoo SDSerum serotonin levels in patients with epileptic seizures. Epilepsia. 2018 Jun;59(6):e91-e97. doi: 10.1111/epi.14198. Epub 2018 May 17. PubMed PMID: 29771456.
  • Zhao X, Lhatoo SD. Seizure detection: do current devices work? And when can they be useful? Curr Neurol Neurosci Rep. 2018 May 23;18(7):40. doi: 10.1007/s11910-018-0849-z. Review. PubMed PMID: 29796939.
  • Lacuey N, Vilella L, Hampson JP, Sahadevan J, Lhatoo SDIctal laryngospasm monitored by video-EEG and polygraphy: a potential SUDEP mechanism. Epileptic Disord. 2018 Apr 1;20(2):146-150. doi: 10.1684/epd.2018.0964. PubMed PMID: 29620011.
  • Lacuey N, Zonjy B, Hampson JP, Rani MRS, Zaremba A, Sainju RK, Gehlbach BK, Schuele S, Friedman D, Devinsky O, Nei M, Harper RM, Allen L, Diehl B, Millichap JJ, Bateman L, Granner MA, Dragon DN, Richerson GB, Lhatoo SDThe incidence and significance of periictal apnea in epileptic seizures. Epilepsia. 2018 Mar;59(3):573-582. doi: 10.1111/epi.14006. Epub 2018 Jan 16. PubMed PMID: 29336036.
  • Lacuey N, Hampson JP, Theeranaew W, Zonjy B, Vithala A, Hupp NJ, Loparo KA, Miller JP, Lhatoo SDCortical Structures Associated With Human Blood Pressure Control. JAMA Neurol. 2018 Feb 1;75(2):194-202. doi: 10.1001/jamaneurol.2017.3344. PubMed PMID: 29181526; PubMed Central PMCID: PMC5838633.
  • Allen LA, Harper RM, Kumar R, Guye M, Ogren JA, Lhatoo SD, Lemieux L, Scott CA, Vos SB, Rani S, Diehl B. Dysfunctional Brain Networking among Autonomic Regulatory Structures in Temporal Lobe Epilepsy Patients at High Risk of Sudden Unexpected Death in Epilepsy. Front Neurol. 2017 Oct 16;8:544. doi: 10.3389/fneur.2017.00544. eCollection 2017. PubMed PMID: 29085330; PubMed Central PMCID: PMC5650686.
  • Shi J, Lacuey N, Lhatoo SSurgical outcome of MRI-negative refractory extratemporal lobe epilepsy. Epilepsy Res. 2017 Apr 20;133:103-108. doi: 10.1016/j.eplepsyres.2017.04.010. [Epub ahead of print] PubMed PMID: 28477458.
  • Lacuey N, Zonjy B, Londono L, Lhatoo SD. Amygdala and hippocampus are symptomatogenic zones for central apneic seizures.Neurology. 2017 Feb 14;88(7):701-705. doi: 10.1212/WNL.0000000000003613. Epub 2017 Jan 13. PubMed PMID: 28087822; PubMed Central PMCID: PMC5317387.
  • Lhatoo S, Lacuey N, Ryvlin P. Principles of Stereotactic Electroencephalography in Epilepsy Surgery. J Clin Neurophysiol. 2016 Dec;33(6):478-482. Review. PubMed PMID: 26840984.
  • Devinsky O, Hesdorffer DC, Thurman DJ, Lhatoo S, Richerson G.Omega-3 fatty acids and SUDEP prevention – Authors’ reply. Lancet Neurol. 2016 Dec;15(13):1303-1304. doi: 10.1016/S1474-4422(16)30285-X. PubMed PMID: 27839639.
  • Sajatovic M, Tatsuoka C, Welter E, Perzynski AT, Colon-Zimmermann K, Van Doren JR, Bukach A, Lawless ME, Ryan ER, Sturniolo K, Lhatoo S. Targeted Self-Management of Epilepsy and Mental Illness for individuals with epilepsy and psychiatric comorbidity. Epilepsy Behav. 2016 Nov;64(Pt A):152-159. doi: 10.1016/j.yebeh.2016.08.012. Epub 2016 Oct 12. PubMed PMID: 27743547.
  • Munube D, Katabira E, Ndeezi G, Joloba M, Lhatoo S, Sajatovic M, Tumwine JK. Prevalence of stroke in children admitted with sickle cell anaemia to Mulago Hospital. BMC Neurol. 2016 Sep 17;16:175. doi: 10.1186/s12883-016-0704-2. PubMed PMID: 27639979; PubMed Central PMCID: PMC5026778.
  • Lhatoo S, Noebels J, Whittemore V, NINDS Center for SUDEP Research. Sudden unexpected death in epilepsy: Identifying risk and preventing mortality. Epilepsia. 2015 Nov;56(11):1700–1706. doi: 10.1111/epi.13134 Pubmed PMID: 26494436
  • Kaiboriboon K, Malkhachroum AM, Zrik A, Daif A, Schiltz NM, Labiner DM, Lhatoo SD. Epilepsy surgery in the United States: Analysis of data from the National Association of Epilepsy Centers.Epilepsy Res. 2015 Oct;116:105–109. doi: 10.1016/j.eplepsyres.2015.07.007 Pubmed PMID: 26310969
  • Sethi NK, Lhatoo SD, Nashef L, Tomson T, Ryvlin P, Mortality on Epilepsy Monitoring Units Study, Tao J, Liebenthal J, Wu S, Rose S, Ebersole JS. Association of prone position with sudden unexpected death in epilepsy. Neurology. 2015 Sep 29;85(13):1185–1186. doi: 10.1212/WNL.0000000000002011 Pubmed PMID: 26416803
  • Thom M, Michalak Z, Wright G, Dawson T, Hilton D, Joshi A, Diehl B, Koepp M, Lhatoo S, Sander JW, Sisodiya SM. Audit of practice in sudden unexpected death in epilepsy (SUDEP) post mortems and neuropathological findings. Neuropathol Appl Neurobiol. 2015 Aug 24; doi: 10.1111/nan.12265 Pubmed PMID: 26300477
  • Pestana Knight EM, Schiltz NK, Bakaki PM, Koroukian SM, Lhatoo SD, Kaiboriboon K. In response: Epilepsy surgery trends in the U.S.-Differences between kids and adults. Epilepsia. 2015 Aug;56(8):1321–1322. doi: 10.1111/epi.13058 Pubmed PMID: 26235740
  • Lacuey N, Davila JC, Zonjy B, Amina S, Couce M, Turnbull J, Miller J, Lüders H, Lhatoo SDLesion-negative anterior cingulate epilepsy. Epileptic Disord. 2015 Jun;17(2):134–142. doi: 10.1684/epd.2015.0749 Pubmed PMID: 26056053
  • Lacuey N, Zonjy B, Kahriman ES, Marashly A, Miller J, Lhatoo SD, Lüders HO. Homotopic reciprocal functional connectivity between anterior human insulae. Brain Struct Funct. 2015 May 21; doi: 10.1007/s00429-015-1065-0 Pubmed PMID: 25993901
  • Pestana Knight EM, Schiltz NK, Bakaki PM, Koroukian SM, Lhatoo SD, Kaiboriboon K. Increasing utilization of pediatric epilepsy surgery in the United States between 1997 and 2009. Epilepsia. 2015 Mar;56(3):375–381. doi: 10.1111/epi.12912 Pubmed PMID: 25630252
  • Munyon C, Sweet J, Luders H, Lhatoo S, Miller J. The 3-dimensional grid: a novel approach to stereoelectroencephalography.Neurosurgery. 2015 Mar;11 Suppl 2:127–133; discussion 133–134. doi: 10.1227/NEU.0000000000000649 Pubmed PMID: 25599199
  • Lüders H, Amina S, Eccher M, Devereaux M, Lhatoo S.Commentary: Should consciousness be used to describe seizures and what terms should be applied: Epilepsia’s survey results. Epilepsia. 2015 Mar;56(3):344. doi: 10.1111/epi.12921 Pubmed PMID: 25740046
  • Jayapandian C, Wei A, Ramesh P, Zonjy B, Lhatoo SD, Loparo K, Zhang G-Q, Sahoo SS. A scalable neuroinformatics data flow for electrophysiological signals using MapReduce. Front Neuroinform. 2015;9:4. doi: 10.3389/fninf.2015.00004 Pubmed PMID: 25852536



Cleveland FES Center

Director, Epilepsy Center
University Hospitals Cleveland Medical Center

Professor, Neurology, School of Medicine
Case Western Reserve University


Program Contact
Samden Lhatoo

Contact Number
(216) 844-5855

Contact Email