Lee, Seungyup, PhD

Dr. Seungyup Lee is an Assistant Professor in Cardiovascular Medicine and Biomedical Engineering at Case Western Reserve University.

With over 15 years of experience in cardiovascular engineering, cardiac electrophysiology, and medical devices, Dr. Lee’s research focuses on the mechanisms of atrial fibrillation and advanced signal processing. He has contributed to both animal and human models to better understand persistent and long-standing atrial fibrillation, developing innovative signal processing algorithms and applying them in clinical studies to enhance targeted ablation procedures.

Dr. Lee is also actively involved in mentoring and collaborative research initiatives.

RESEARCH PROGRAMS

Dr. Lee’s research spans cardiac electrophysiology, biomedical engineering, and medical device innovation. His laboratory investigates mechanisms of atrial fibrillation through advanced epicardial mapping and real-time signal processing, aiming to identify and target sources of abnormal heart rhythms. His multidisciplinary toolkit combines animal models, clinical studies, and engineering approaches to improve ablation outcomes and develop new strategies for arrhythmia treatment.

MAJOR PROJECTS & FUNDING

Dr. Lee’s work has been supported by national and international agencies, including the National Institutes of Health and the UK Research and Innovation Medical Research Council. Major projects include feasibility studies of targeted ablation devices, development of voltage-independent depth control for ablation systems, and paradigm-shifting investigations into electrophysiological mechanisms of atrial fibrillation. His recent publications address both technical and clinical challenges in ablation and mapping, with ongoing collaborations across the US and UK.

HONORS & RECOGNITION

• Editorial Board Member, Journal of the American College of Cardiology (JACC): Clinical Electrophysiology, 2025
• Editorial Board Member, Heart Rhythm O2 Journal, 2025
• Fellow of the Heart Rhythm Society (FHRS), Heart Rhythm Society, 2022
• Guest Editor, International Journal of Environmental Research and Public Health (2022–2023)
• Notable Korean Scientist, Biological Research Information Center (BRIC), 2015