Lewis, Stephen J, PhD

Dr. Stephen Lewis manages a multidisciplinary research program and has generated deep expertise in autonomic neurophysiology and neuropharmacology using freely-moving animal models.

His laboratory employs a wide array of techniques including in vivo nerve recording and stimulation, whole-body plethysmography, in situ brainstem electrophysiology, single-cell patch-clamp electrophysiology, and molecular/proteomic approaches.

Dr. Lewis has contributed to over 200 peer-reviewed publications and holds 7 patents related to autonomic nervous system modulation. He serves as Editor-in-Chief for the Journal of Pharmaceutical and Pharmacology Research and on the editorial boards of Medicines, Pharmaceuticals, Frontiers in Pharmacology, and Frontiers in Neuroscience.

RESEARCH PROGRAMS

• Autonomic neurophysiology and neuropharmacology in freely-moving rodent models
• Cardiovascular and hemodynamic regulation via baroreceptor and renal nerve stimulation
• Ventilatory control and carotid body chemoreceptor physiology
• Sympathetic nervous system modulation and nitrosyl factor signaling
• Photobiomodulation and infrared neuromodulation of peripheral nerves
• Bioelectronic medicine and novel electrode technology for autonomic nerves

MAJOR PROJECTS & FUNDING

• NIH SPARC Research, Novel Nanowire Interface with the Autonomic Nervous System to Study Hypertension
• NIH SPARC Research, Functional Mapping of the Afferent and Efferent Projections of the Superior Cervical Ganglion Interactome
• NIH-Funded Research, Infrared Neuromodulation Reveals a New Understanding of Ganglion Organization
• NIH-Funded Research, Defining Gastric Vagal Mechanisms Underlying Emetic Activation Using Novel
• Electrophysiological and Optical Mapping Technology
• Galvani Bioelectronics Grants (×6),Including electrical stimulation of the aortic depressor nerves and chronic recording/stimulating/blocking of carotid sinus nerves in rats

HONORS & RECOGNITION

• 2003 Pfizer Award for Research Excellence, Pfizer
• Member, 8 NIH Review Panels (Y2021/Y2025)
• Member, 7 Department of Defense (CDMRP) Review Panels (Y2021/Y2025)
• Holder of 7 U.S. Patents (Nos. 10,080,732; 10,543,187; 10,881,633; 17/141,999; 17/742,040; 17/696,204)
• Editor-in-Chief, Journal of Pharmaceutical and Pharmacology Research
• Editorial Board Member, Frontiers in Pharmacology
• Editorial Board Member, Frontiers in Neuroscience
• Editorial Board Member, Medicines and Pharmaceuticals