Remote Dynamic Cycling for the Customized Off-site Rehab in Parkinson’s Disease
This study aims to develop a novel and accessible way to deliver effective and customized exercise-based rehabilitation to those suffering from Parkinson’s disease.
Parkinson’s disease (PD) progressively deteriorates motor function. Successful rehabilitation, leading to a favorable course of movement disorders in PD, is contingent upon a frequent, regular, and patient-specific exercise regimen that is customized to the individual needs. This requires regular interventions from the provider and frequent visits to the rehab facility.

Lack of access, poor social support, inability to travel, home-bound status, or pandemics are significant hurdles in delivering effective rehab to the PD patients. The investigators’ vision is to offer customized and cost-effective PD rehab using a remotely operated technology near or at the patients’ homes. This technology would be remotely monitored and customized online to titrate therapeutic outcomes optimized for each patient.
The proof of this concept was established in the investigators’ laboratory, a technology called dynamic cycling. The highlight of the technology is a stationary bike operating at a rapid speed (cadence) with programmable variability in speed and power/torque hence promoting motor performance superior to traditional motorized bikes (i.e. static cycling). The next step towards the ultimate vision of at-home exercise therapy is a remotely operated dynamic bike. The study will objectively examine the efficacy of a novel, remotely delivered and remotely adjusted dynamic cycling paradigm using remotely monitored motor outcomes. Comparisons will be made with remote static cycling.
Detailed study information is available at https://clinicaltrials.gov/study/NCT05298150.
For More Information
Program Contact: Aasef G. Shaikh MD, PhD
Contact Number: (216) 791-3800 ext. 60000
Contact Email: Aasef.Shaikh@va.gov
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