Peripheral Nerve Stimulation for Shoulder Pain: Dose Response

The primary objective of this trial is to explore the mechanism for Hemiplegic Shoulder Pain (HSP) reduction due to treatment with peripheral nerve stimulation (PNS).

This technique now needs to be compared to “usual care,” which consists of elements of standard occupational and physical therapies.

About This Study

We will explore the association of subject-specific clinical and demographic information and pain relief from PNS. We will explore the possible role of central sensitization mechanisms in perpetuating pain via measures of sensory and pain perception. Lastly, we will explore the dose-response association of muscle-contraction from PNS and pain reduction, completion of activities of daily living (ADLs), and improvement in quality of life.

Study Information

Stroke survivors with shoulder pain will be randomly assigned to receive the electrical stimulation therapy over a 4-week period, beginning with a 1-week stabilization period, followed by 3 weeks of varying levels of stimulation every day. Length of stimulation treatment per day ranges from 3-9 hours per day, depending on to which group the participant is randomly assigned. Total time of electrode implantation is no more than 29 days.

Detailed program information and criteria available at:

Principal Investigators: Richard Wilson, MD

Program Contact: Krissy Hansen, PT

Contact Number: (216) 957-3584

Contact Email:

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