Bhadra, Niloy, M.D., Ph.D.

Research Statement

My ongoing research is investigating high-frequency waveforms for inducing a rapid yet fully reversible peripheral motor nerve block, which will have clinical applications in the control of spasticity and other movement disorders. The various aspects of this research are; computer modeling to investigate the mechanism of high-frequency block, designing wave forms that will not produce an onset response in the nerve when first turned on, designing and testing optimal nerve cuff electrodes for block testing chronic safety of these waveforms in animal models, ex-vivo testing of human nerves and pre-operative testing in human subjects.

Professional Affiliations

• Investigator, Cleveland FES Center
• Research Assistant Professor, Department of Biomedical Engineering, Case Western Reserve University, Cleveland OH
• Bioscientific Staff, Department of Orthopaedics, MetroHealth Medical Center, Cleveland, OH

Publications (Select)

• Ackermann DM Jr, Foldes EL, Bhadra N, Kilgore KL, Conduction block of peripheral nerve using high-frequency alternating currents delivered through an intrafascicular electrode, Muscle Nerve. 2010 Jan;41(1):117-9. PMID:19813186.
• Kilgore KL, Foldes EA, Ackermann DM, Bhadra N. Combined direct current and high frequency nerve block for elimination of the onset response. Conf Proc IEEE Eng Med Biol Soc. 2009;2009:197-9 PubMed PMID:19964208.
• Ackermann D, Foldes EL, Bhadra N, Kilgore KL. Electrode design for high frequency block; effect of bipolar separation on block thresholds and the onset response. Conf Proc IEEE Eng Med Biol Soc. 2009;2009:654-7. PubMed PMID:19963721.
• Bhadra N, Foldes EL, Ackermann D, Kilgore KL. Reduction of the onset response in high frequency nerve block with amplitude ramps from non-zero amplitudes. Conf Proc IEEE Eng Med Biol Soc. 2009;2009:650-3. PubMed PMID:19963720.
• Foldes EL, Ackermann D, Bhadra N, Kilgore KL. Counted cycles method to quantify the onset response in high-frequency peripheral nerve block. Conf Proc IEEE Eng Med Biol Soc. 2009;2009:614-7 PubMed PMID:19963719.
• Ackermann DM Jr, Foldes EL, Bhadra N, Kilgore KL. Effect of bipolar cuff electrode design on block thresholds in high-frequency electrical neural conduction block. IEEE Trans Neural Syst Rehabil Eng. 2009 Oct;17(5):469-77. Epub2009 Oct 16. PubMed PMID:19840914.Bhadra N, Chae J. Implantable neuroprosthetic technology. NeuroRehabilitation. 2009;25(1):69-83. Review. PubMed PMID:19713620.

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