Strohl, Kingman, MD

Research Statement

Dr. Kingman Strohl’s research is in sleep disordered breathing. He is currently investigating the genetic basis of differences in rat ventilatory patterns. He has just completed a comprehensive QTL analysis looking at two informative rat strains with varying respiratory patterns. With this information, he is now embarking on a high density mapping project of informative areas identified in the rat genome.

Professional Affiliations

  • Investigator, Cleveland FES Center
  • Program Director, Sleep Medicine, University Hospitals Cleveland Medical Center, Cleveland, OH
  • Professor, Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH

Publications

  • Gillespie MB, Soose RJ, Woodson BT, Strohl KP, Maurer JT, de Vries N, Steward DL, Baskin JZ, Badr MS, Lin HS, Padhya TA, Mickelson S, Anderson WM, Vanderveken OM, Strollo PJ Jr; STAR Trial Investigators.. Upper Airway Stimulation for Obstructive Sleep Apnea: Patient-Reported Outcomes after 48 Months of Follow-up. Otolaryngol Head Neck Surg. 2017 Apr;156(4):765-771. doi: 10.1177/0194599817691491. Epub 2017 Feb 14. PubMed PMID: 28194999.
  • Netzer NC, Strohl KP, Högel J, Gatterer H, Schilz R. Right ventricle dimensions and function in response to acute hypoxia in healthy human subjects. Acta Physiol (Oxf). 2017 Feb;219(2):478-485. doi: 10.1111/apha.12740. Epub 2016 Jul 15. PubMed PMID: 27332955.
  • Fujita Y, Yamauchi M, Uyama H, Kumamoto M, Koyama N, Yoshikawa M, Strohl KP, Kimura H. Variability of breathing during wakefulness while using CPAP predicts adherence. Respirology. 2017 Feb;22(2):386-393. doi: 10.1111/resp.12900. Epub 2016 Sep 13. PubMed PMID: 27623518.
  • Gillombardo CB, Darrah R, Dick TE, Moore M, Kong N, Decker MJ, Han F, Yamauchi M, Dutschmann M, Azzam S, Strohl KP. C57BL/6J mouse apolipoprotein A2 gene is deterministic for apnea. Respir Physiol Neurobiol. 2017 Jan;235:88-94. doi: 10.1016/j.resp.2016.10.006. Epub 2016 Oct 15. PubMed PMID: 27756649; PubMed Central PMCID: PMC5136301.
  • Paz Y Mar HL, Hazen SL, Tracy RP, Strohl KP, Auckley D, Bena J, Wang L, Walia HK, Patel SR, Mehra R. Effect of Continuous Positive Airway Pressure on Cardiovascular Biomarkers: The Sleep Apnea Stress Randomized Controlled Trial. Chest. 2016 Jul;150(1):80-90. doi: 10.1016/j.chest.2016.03.002. Epub 2016 Mar 18. PubMed PMID: 26997243; PubMed Central PMCID: PMC4980547.
  • Koo BB, Won C, Selim BJ, Qin L, Jeon S, Redeker NS, Bravata DM, Strohl KP, Concato J, Zinchuk AV, Yaggi HK. Erratum to: The Determining Risk of Vascular Events by Apnea Monitoring (DREAM) study: design, rationale, and methods. Sleep Breath. 2016 May;20(2):901. PubMed PMID: 26971325.
  • Koo BB, Won C, Selim BJ, Qin L, Jeon S, Redeker NS, Bravata DM, Strohl KP, Concato J, Zinchuk AV, Yaggi HK. The Determining Risk of Vascular Events by Apnea Monitoring (DREAM) study: design, rationale, and methods. Sleep Breath. 2016 May;20(2):893-900. doi: 10.1007/s11325-015-1254-3. Epub 2015 Dec 7. Erratum in: Sleep Breath. 2016 May;20(2):901. PubMed PMID: 26642771.
  • Wang JY, Han F, Dong SX, Li J, An P, Zhang XZ, Chang Y, Zhao L, Zhang XL, Liu YN, Yan H, Li QH, Hu Y, Lv CJ, Gao ZC, Strohl KP. Cerebrospinal Fluid Orexin A Levels and Autonomic Function in Kleine-Levin Syndrome. Sleep. 2016 Apr 1;39(4):855-60. doi: 10.5665/sleep.5642. PubMed PMID: 26943469; PubMed Central PMCID: PMC4791619.
  • Soose RJ, Woodson BT, Gillespie MB, Maurer JT, de Vries N, Steward DL, Strohl KP, Baskin JZ, Padhya TA, Badr MS, Lin HS, Vanderveken OM, Mickelson S, Chasens E, Strollo PJ Jr; STAR Trial Investigators.. Upper Airway Stimulation for Obstructive Sleep Apnea: Self-Reported Outcomes at 24 Months. J Clin Sleep Med. 2016 Jan;12(1):43-8. doi: 10.5664/jcsm.5390. PubMed PMID: 26235158; PubMed Central PMCID: PMC4702198.
  • Woodson BT, Soose RJ, Gillespie MB, Strohl KP, Maurer JT, de Vries N, Steward DL, Baskin JZ, Badr MS, Lin HS, Padhya TA, Mickelson S, Anderson WM, Vanderveken OM, Strollo PJ Jr; STAR Trial Investigators.. Three-Year Outcomes of Cranial Nerve Stimulation for Obstructive Sleep Apnea: The STAR Trial. Otolaryngol Head Neck Surg. 2016 Jan;154(1):181-8. doi: 10.1177/0194599815616618. Epub 2015 Nov 17. PubMed PMID: 26577774.
  • Lewis O, Morkous S, Strohl KP, Rosen CL. Actigraphy as a “Truth-Buster“. J Clin Sleep Med. 2015 Dec 15;11(12):1466-9. doi: 10.5664/jcsm.5292. PubMed PMID: 26235154; PubMed Central PMCID: PMC4661341.
  • Strollo PJ Jr, Gillespie MB, Soose RJ, Maurer JT, de Vries N, Cornelius J, Hanson RD, Padhya TA, Steward DL, Woodson BT, Verbraecken J, Vanderveken OM, Goetting MG, Feldman N, Chabolle F, Badr MS, Randerath W, Strohl KP; Stimulation Therapy for Apnea Reduction (STAR) Trial Group.. Upper Airway Stimulation for Obstructive Sleep Apnea: Durability of the Treatment Effect at 18 Months. Sleep. 2015 Oct 1;38(10):1593-8. doi: 10.5665/sleep.5054. PubMed PMID: 26158895; PubMed Central PMCID: PMC4576333.
  • Yamauchi M, Fujita Y, Kumamoto M, Yoshikawa M, Ohnishi Y, Nakano H, Strohl KP, Kimura H. Nonrapid Eye Movement-Predominant Obstructive Sleep Apnea: Detection and Mechanism. J Clin Sleep Med. 2015 Sep 15;11(9):987-93. doi: 10.5664/jcsm.5010. PubMed PMID: 25845901; PubMed Central PMCID: PMC4543259.
  • Fechtner L, Ali ME, Sattar A, Moore M, Strohl KP. Fentanyl effects on breath generation in C57BL/6J and A/J mouse strains. Respir Physiol Neurobiol. 2015 Aug 15;215:20–29. doi: 10.1016/j.resp.2015.04.011 Pubmed PMID: 25936679
  • Safiruddin F, Vanderveken OM, de Vries N, Maurer JT, Lee K, Ni Q, Strohl KP. Effect of upper-airway stimulation for obstructive sleep apnoea on airway dimensions. Eur Respir J. 2015 Jan;45(1):129–138. doi: 10.1183/09031936.00059414 Pubmed PMID: 25186270
  • Getsy PM, Davis J, Coffee GA, May WJ, Palmer LA, Strohl KP, Lewis SJ. Enhanced non-eupneic breathing following hypoxic, hypercapnic or hypoxic-hypercapnic gas challenges in conscious mice. Respir Physiol Neurobiol. 2014 Dec 1;204:147–159. doi: 10.1016/j.resp.2014.09.006 Pubmed PMID: 25242462
  • Decker M, Yamauchi M, Strohl KP. Keep the airway open and let the brain sleep. Am J Respir Crit Care Med. 2014 Dec 1;190(11):1207–1209. doi: 10.1164/rccm.201410-1939ED Pubmed PMID: 25436780
  • Feng P, Hu Y, Vurbic D, Akladious A, Strohl KP. Chromosome 1 replacement increases brain orexins and antidepressive measures without increasing locomotor activity. J Psychiatr Res. 2014 Dec;59:140–147. doi: 10.1016/j.jpsychires.2014.08.008 Pubmed PMID: 25190041
  • Woodson BT, Gillespie MB, Soose RJ, Maurer JT, de Vries N, Steward DL, Baskin JZ, Padhya TA, Lin H, Mickelson S, Badr SM, Strohl KP, Strollo PJ, STAR Trial Investigators, STAR Trial Investigators. Randomized controlled withdrawal study of upper airway stimulation on OSA: short- and long-term effect. Otolaryngol Head Neck Surg. 2014 Nov;151(5):880–887. doi: 10.1177/0194599814544445 Pubmed PMID: 25205641

Contact Information

Contact Name: Kingman Strohl
Contact Number: 216-791-8500
Contact Email: kingman.strohl@case.edu