Selkirk, Stephen, MD, PhD

Research Statement

I am a Neurologist on the Spinal Cord Injury Division at the Louis Stokes Cleveland VA Medical Center.  My clinical interest is Multiple Sclerosis.
My research interests included understanding the mechanism of demyelination in the Central Nervous System (CNS) and developing therapies that enhance repair and remyelination.  I am also involved in research to enhance and/or development novel viral vectors to transfer gene expression to the CNS.

Professional Affiliations

  • Investigator, Cleveland FES Center
  • Staff Neurologist, Spinal Cord Injury Division, and Director, Advanced SCI Fellowship, Louis Stokes Cleveland VA Medical Center, Cleveland, OH
  • Assistant Professor, Department of Neurology, School of Medicine, Case Western Reserve University, Cleveland, OH
  • Director, Cleveland VA ALS Center of Excellence,  Louis Stokes Cleveland VA Medical Center, Cleveland, OH

 Publications

  • Ravikumar M, Sunil S, Black J, Barkauskas DS, Haung AY, Miller RH, Selkirk SM, Capadona JR. The roles of blood-derived macrophages and resident microglia in the neuroinflammatory response to implanted Intracortical microelectrodes. Biomaterials. 2014 Sep;35(28):8049-64. doi: 10.1016/j.biomaterials.2014.05.084. Epub 2014 Jun 24. PubMed PMID: 24973296.
  • McClellan F, Washington M, Ruff R, Selkirk SM. Early and innovative symptomatic care to improve quality of life of ALS patients at Cleveland VA ALS Center. J Rehabil Res Dev. 2013 Jul;50(4):vii-xvi. PubMed PMID: 23934878.
  • McClellan F, Washington M, Ruff R, Selkirk SM. Developing a system of care for ALS patients at the Louis Stokes Cleveland VA Medical Center, Spinal Cord Injury Division. J Rehabil Res Dev. 2013 Apr;50(2):xi-xxi. PubMed PMID: 23761009.
  • Caprariello AV, Mangla S, Miller RH, Selkirk SM. Apoptosis of oligodendrocytes in the central nervous system results in rapid focal demyelination. Ann Neurol.2012 Sep;72(3):395-405. doi: 10.1002/ana.23606. PubMed PMID: 23034912; PubMed Central PMCID: PMC3464960.
  • Ravikumar M, Jain S, Miller RH, Capadona JR, Selkirk SM. An organotypic spinal cord slice culture model to quantify neurodegeneration. J Neurosci Methods. 2012 Nov 15;211(2):280-8. doi: 10.1016/j.jneumeth.2012.09.004. Epub 2012 Sep 10. PubMed PMID: 22975474.

 

Research Programs

  • Development of animal model of oligodendrocyte apoptosis mediated demyelination.
  • Studying mechanisms that promote myelin repair and neuronal protection in animal models of Multiple Sclerosis.
  • Modulating the immune response in the central nervous system to promote axon integrity.
  • Fundamental mechanisms of gene therapy and retroviral vectors
  • Enhancing gait in patients with multiple sclerosis through implanted FES systems.

 Contact Information

Contact Name: Stephan Selkirk, M.D., Ph.D.
Contact Number: (216) 791-3800 x6076
Contact Email: Stephen.selkirk@va.gov