Shaikh, Aasef, MD, PhD

Research Statement

Aasef Shaikh is a neurologist and neuroscientist from Daroff-Dell’Osso Ocular Motility Laboratory at Cleveland VA Medical Center. His research focuses on the application of control systems engineering to approach complex disorders of the vestibular system, eye movements, head movements, gait and balance. The overarching goal is to discover novel network connections and leverage their influence to modulate the motor circuits artificially for the treatment of intractable neurological conditions. Dr. Shaikh was the recipient of the prestigious American Academy of Neurology Alliance Founders Award and The American Neurological Association Grass Foundation Award in Neuroscience.

Professional Affiliations

  • Investigator, Cleveland FES Center
  • Neurologist and Neuroscientist, Louis Stokes Cleveland VA Medical Center, Cleveland, OH
  • Neurologist, University Hospitals Cleveland Medical Center, Cleveland, OH
  • Assistant Professor, Neurology, School of Medicine, Case Western Reserve University, Cleveland, OH

Publications (Select)

  • Perugini A, Ditterich J, Shaikh AG, Knowlton BJ, Basso MA. Paradoxical Decision-Making: A Framework for Understanding Cognition in Parkinson’s Disease.  Trends Neurosci. 2018 Aug;41(8):512-525. doi: 10.1016/j.tins.2018.04.006. Epub 2018 May 7. Review. PubMed PMID: 29747856.
  • Rufa A, Shaikh AG. Editorial: Ocular Motor and Vestibular Deficits in Neurometabolic, Neurogenetic, and Neurodegenerative Diseases. Front Neurol. 2018  Jul 18;9:567. doi: 10.3389/fneur.2018.00567. eCollection 2018. PubMed PMID: 30072945; PubMed Central PMCID: PMC6058526.
  • Rizvi MT, Cameron L, Kilbane C, Shaikh AG. Paraneoplastic seesaw nystagmus and opsoclonus provides evidence for hyperexcitable reciprocally innervating mesencephalic network. J Neurol Sci. 2018 Jul 15;390:239-245. doi: 10.1016/j.jns.2018.05.002. Epub 2018 May 3. PubMed PMID: 29801897.
  • Shaikh AG, Zee DS. Eye Movement Research in the Twenty-First Century-a Window to the Brain, Mind, and More. Cerebellum. 2018 Jun;17(3):252-258. doi: 10.1007/s12311-017-0910-5. PubMed PMID: 29260439.
  • Kang SL, Shaikh AG, Ghasia FF. Vergence and Strabismus in Neurodegenerative Disorders. Front Neurol. 2018 May 16;9:299. doi: 10.3389/fneur.2018.00299. eCollection 2018. Review. PubMed PMID: 29867716; PubMed Central PMCID: PMC5964131.
  • Ghasia FF, Otero-Millan J, Shaikh AG. Abnormal fixational eye movements in strabismus. Br J Ophthalmol. 2018 Feb;102(2):253-259. doi: 10.1136/bjophthalmol-2017-310346. Epub 2017 Jul 11. PubMed PMID: 28698242.
  • Shaikh AG, Finkelstein SR, Schuchard R, Ross G, Juncos JL. Fixational eye movements in Tourette syndrome. Neurol Sci. 2017 Nov;38(11):1977-1984. doi: 10.1007/s10072-017-3069-4. Epub 2017 Aug 16. PubMed PMID: 28815321.
  • Shaikh AG, Factor SA, Juncos J. Saccades in progressive supranuclear palsy – maladapted, irregular, curved, and slow. Mov Disord Clin Pract. 2017 Sep-Oct;4(5):671-681. doi: 10.1002/mdc3.12491. Epub 2017 Aug 11. PubMed PMID: 29333474; PubMed Central PMCID: PMC5764187.
  • Shaikh AG, Ghasia FF. Novel Eye Movement Disorders in Whipple’s Disease-Staircase Horizontal Saccades, Gaze-Evoked Nystagmus, and Esotropia. Front Neurol. 2017 Jul 11;8:321. doi: 10.3389/fneur.2017.00321. eCollection 2017. PubMed PMID: 28744253; PubMed Central PMCID: PMC5504231.
  • Shaikh AG, Solomon D. Effects of Sustained Otolith-Only Stimulation on Post-Rotational Nystagmus. Cerebellum. 2017 Jun;16(3):683-690. doi: 10.1007/s12311-017-0847-8. PubMed PMID: 28224454.
  • Shaikh AG, Straumann D, Palla A. Motion Illusion-Evidence towards Human Vestibulo-Thalamic Projections. Cerebellum. 2017 Jun;16(3):656-663. doi: 10.1007/s12311-017-0844-y. PubMed PMID: 28127679; PubMed Central PMCID: PMC5429207.
  • Kang S, Shaikh AG. Acquired pendular nystagmus. J Neurol Sci. 2017 Apr 15;375:8-17. doi: 10.1016/j.jns.2017.01.033. Epub 2017 Jan 10. Review. PubMed PMID: 28320194; PubMed Central PMCID: PMC5363284.
  • Shaikh AG, Ghasia FF. Fixational saccades are more disconjugate in adults than in children. PLoS One. 2017 Apr 13;12(4):e0175295. doi: 10.1371/journal.pone.0175295. eCollection 2017. PubMed PMID: 28406944; PubMed Central PMCID: PMC5391133.
  • Shaikh AG. Tremor analysis separates Parkinson’s disease and dopamine receptor blockers induced parkinsonism. Neurol Sci. 2017 Feb 22. doi: 10.1007/s10072-017-2852-6. [Epub ahead of print] PubMed PMID: 28229302.
  • Sedov A, Popov V, Shabalov V, Raeva S, Jinnah HA, Shaikh AG. Physiology of midbrain head movement neurons in cervical dystonia. Mov Disord. 2017 Feb 20. doi: 10.1002/mds.26948. [Epub ahead of print] PubMed PMID: 28218416.
  • Shaikh AG, Wong AL, Optican LM, Zee DS. Impaired Motor Learning in a Disorder of the Inferior Olive: Is the Cerebellum Confused? Cerebellum. 2017 Feb;16(1):158-167. doi: 10.1007/s12311-016-0785-x. PubMed PMID: 27165043; PubMed Central PMCID: PMC5104669.
  • Shaikh AG, Zee DS, Crawford JD, Jinnah HA. Reply: Contributions of visual and motor signals in cervical dystonia. Brain. 2017 Jan;140(Pt 1):e5. doi: 10.1093/brain/aww292. Epub 2016 Dec 19. PubMed PMID: 27993889.
  • Shaikh AG, Zee DS, Crawford JD, Jinnah HA. Cervical dystonia: a neural integrator disorder. Brain. 2016 Oct;139(Pt 10):2590-2599. Epub 2016 Jun 20. PubMed PMID: 27324878.
  • Ghasia FF, Wilmot G, Ahmed A, Shaikh AG. Strabismus and Micro-Opsoclonus in Machado-Joseph Disease. Cerebellum. 2016 Aug;15(4):491-7. doi: 10.1007/s12311-015-0718-0. PubMed PMID: 26306823.
  • Shaikh AG, Wilmot G. Opsoclonus in a patient with increased titers of anti-GAD antibody provides proof for the conductance-based model of saccadic oscillations. J Neurol Sci. 2016 Mar 15;362:169-73. doi: 10.1016/j.jns.2016.01.038. Epub 2016 Jan 21. PubMed PMID: 26944142.
  • Cooperrider J, Gale JT, Gopalakrishnan R, Chan HH, Wathen C, Park HJ, Baker KB, Shaikh AG, Machado AG. Differential frequency modulation of neural activity in the lateral cerebellar nucleus in failed and successful grasps. Exp Neurol. 2016 Mar;277:27-34. doi: 10.1016/j.expneurol.2015.12.007. Epub 2015 Dec 14. PubMed PMID: 26698925; PubMed Central PMCID: PMC4761293.
  • Shaikh AG, Otero-Millan J, Kumar P, Ghasia FF. Abnormal Fixational Eye Movements in Amblyopia. PLoS One. 2016 Mar 1;11(3):e0149953. doi: 10.1371/journal.pone.0149953. eCollection 2016. PubMed PMID: 26930079; PubMed Central PMCID: PMC4773232.
  • Shaikh AG. Abnormal head oscillations in neuro-ophthalmology and neuro-otology. Curr Opin Neurol. 2016 Feb;29(1):94-103. doi: 10.1097/WCO.0000000000000277. PubMed PMID: 26641814; PubMed Central PMCID: PMC4734901.
  • Ghasia FF, Wilmot G, Ahmed A, Shaikh AG. Strabismus and Micro-Opsoclonus in Machado-Joseph Disease. Cerebellum. 2015 Aug 26; doi: 10.1007/s12311-015-0718-0 Pubmed PMID: 26306823
  • Shaikh AG, Ghasia FF. Misdirected horizontal saccades in pan-cerebellar atrophy. J Neurol Sci. 2015 Aug 15;355(1-2):125–130. doi: 10.1016/j.jns.2015.05.042 Pubmed PMID: 26070655
  • Shaikh AG. Translational neurophysiology of Parkinson’s disease: can’t blink on an eye blink. J Neurophysiol. 2015 Jul;114(1):761–762. doi: 10.1152/jn.00430.2015 Pubmed PMID: 26220606
  • Shaikh AG, Wong A, Zee DS, Jinnah HA. Why are voluntary head movements in cervical dystonia slow? Parkinsonism Relat Disord. 2015 Jun;21(6):561–566. doi: 10.1016/j.parkreldis.2015.03.005 Pubmed PMID: 25818535
  • Ghasia FF, Shaikh AG, Jacobs J, Walker MF. Cross-coupled eye movement supports neural origin of pattern strabismus. Invest Ophthalmol Vis Sci. 2015 May;56(5):2855–2866. doi: 10.1167/iovs.15-16371 Pubmed PMID: 26024072
  • Ghasia FF, Shaikh AG. Uncorrected Myopic Refractive Error Increases Microsaccade Amplitude. Invest Ophthalmol Vis Sci. 2015 Apr;56(4):2531–2535. doi: 10.1167/iovs.14-15882 Pubmed PMID: 25678690
  • Ghasia FF, Shaikh AG. Experimental tests of hypotheses for microsaccade generation. Exp Brain Res. 2015 Apr;233(4):1089–1095. doi: 10.1007/s00221-014-4188-2 Pubmed PMID: 25563497
  • Ghasia FF, Shaikh AG. Head oscillations in infantile nystagmus syndrome. J AAPOS. 2015 Feb;19(1):38–41. doi: 10.1016/j.jaapos.2014.10.024 Pubmed PMID: 25727585
  • Shaikh AG, Sundararajan S. Angioinvasive aspergillosis of the central nervous system. Can J Neurol Sci. 2015 Jan;42(1):64–65. doi: 10.1017/cjn.2014.120 Pubmed PMID: 25525687
  • Ghasia FF, Shaikh AG. Source of high-frequency oscillations in oblique saccade trajectory. Exp Eye Res. 2014 Apr;121:5–10. doi: 10.1016/j.exer.2014.02.009 Pubmed PMID: 24560678

Contact Information

Contact Name: Aasef Shaikh
Contact Number: (216) 844-3192
Contact Email: Aasef.Shaikh@case.edu