Onders, Raymond, MD

Research Statement

Dr. Onders spent his early years at UH developing a minimally invasive procedure to allow ventilator-free breathing for paralyzed patients.  More recently, Dr. Onders has led the effort to apply that same technology in patients with the progressive neurological disorder Amyotrophic Lateral Sclerosis (ALS).

Professional Affiliations

  • Investigator, Cleveland FES Center
  • Director, Adult Minimally Invasive Surgery, University Hospitals Cleveland Medical Center, Cleveland, OH
  • Interim Chief, Division of General and Gastrointestinal Surgery, University Hospitals Cleveland Medical Center, Cleveland, OH
  • Professor, Surgery, School of Medicine, Case Western Reserve University, Cleveland, OH

Publications (Select)

  • Onders RP. The diaphragm: how it affected my career and my life. The search for stability when the problem is instability. Am J Surg. 2014 Dec 18. pii: S0002-9610(14)00620-5. doi: 10.1016/j.amjsurg.2014.12.003. [Epub ahead of print] PubMed PMID: 25637310.
  • Onders RP, Elmo M, Kaplan C, Katirji B, Schilz R. Identification of unexpected respiratory abnormalities in patients with amyotrophic lateral sclerosis through electromyographic analysis using intramuscular electrodes implanted for therapeutic diaphragmatic pacing. Am J Surg. 2014 Dec 11. pii: S0002-9610(14)00598-4. doi: 10.1016/j.amjsurg.2014.10.008. [Epub ahead of print] PubMed PMID: 25648901.
  • Onders RP, Elmo M, Kaplan C, Katirji B, Schilz R. Extended use of diaphragm pacing in patients with unilateral or bilateral diaphragm dysfunction: a new therapeutic option. Surgery. 2014 Oct;156(4):776-84. doi: 10.1016/j.surg.2014.07.021. PubMed PMID: 25239317.
  • Onders RP, Elmo M, Kaplan C, Katirji B, Schilz R. Final analysis of the pilot trial of diaphragm pacing in amyotrophic lateral sclerosis with long-term follow-up: diaphragm pacing positively affects diaphragm respiration. Am J Surg. 2014 Mar;207(3):393-7; discussion 397. doi: 10.1016/j.amjsurg.2013.08.039. Epub 2013 Dec 19. PubMed PMID: 24439161.
  • Posluszny JA Jr, Onders R, Kerwin AJ, Weinstein MS, Stein DM, Knight J, Lottenberg L, Cheatham ML, Khansarinia S, Dayal S, Byers PM, Diebel L. Multicenter review of diaphragm pacing in spinal cord injury: successful not only in weaning from ventilators but also in bridging to independent respiration. J Trauma Acute Care Surg. 2014 Feb;76(2):303-9; discussion 309-10. doi: 10.1097/TA.0000000000000112. PubMed PMID: 24458038.
  • Marks JM, Phillips MS, Tacchino R, Roberts K, Onders R, DeNoto G, Gecelter G, Rubach E, Rivas H, Islam A, Soper N, Paraskeva P, Rosemurgy A, Ross S, Shah S. Single-incision laparoscopic cholecystectomy is associated with improved cosmesis scoring at the cost of significantly higher hernia rates: 1-year results of a prospective randomized, multicenter, single-blinded trial of traditional multiport laparoscopic cholecystectomy vs single-incision laparoscopic cholecystectomy. J Am Coll Surg. 2013 Jun;216(6):1037-47; discussion 1047-8. doi: 10.1016/j.jamcollsurg.2013.02.024. Epub 2013 Apr 23. PubMed PMID: 23619321.
  • Phillips MS, Marks JM, Roberts K, Tacchino R, Onders R, DeNoto G, Rivas H, Islam A, Soper N, Gecelter G, Rubach E, Paraskeva P, Shah S. Intermediate results of a prospective randomized controlled trial of traditional four-port laparoscopic cholecystectomy versus single-incision laparoscopic cholecystectomy. Surg Endosc. 2012 May;26(5):1296-303. doi: 10.1007/s00464-011-2028-z. Epub 2011 Nov 15. PubMed PMID: 22083331.
  • Gonzalez-Bermejo J, Morélot-Panzini C, Salachas F, Redolfi S, Straus C, Becquemin MH, Arnulf I, Pradat PF, Bruneteau G, Ignagni AR, Diop M, Onders R, Nelson T, Menegaux F, Meininger V, Similowski T. Diaphragm pacing improves sleep in patients with amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2012 Jan;13(1):44-54. doi: 10.3109/17482968.2011.597862. Epub 2011 Oct 24. PubMed PMID: 22023158.
  • Onders RP. Functional electrical stimulation: restoration of respiratory function. Handb Clin Neurol. 2012;109:275-82. doi: 10.1016/B978-0-444-52137-8.00017-6. Review. PubMed PMID: 23098719.

Contact Information

Contact Name: Ray Onders
Contact Number: (216) 844-5797
Contact Email: Raymond.Onders@UHhospitals.org