Miller, Jonathan, MD

Research Statement:

I have a broad background in functional neurosurgery, with specific training and expertise in stereotaxy, epilepsy surgery, physiology, and neuromodulation. My clinical and research interests include movement disorders, epilepsy surgery, and development of novel treatments for a variety of disorders using neuromodulation.


Professional Affiliations:
  • Associate Director of Clinical Affairs @ University Hospitals, Cleveland FES Center
  • Director, Functional and Restorative Neurosurgery, University Hospitals Cleveland Medical Center, Cleveland, OH
  • George R. and Constance P. Lincoln Endowed Chair, University Hospitals Cleveland Medical Center, Cleveland, OH
  • Associate Professor of Neurological Surgery, School of Medicine, Case Western Reserve University, Cleveland, OH


Publications (select):
  • Cardinale F, Casaceli G, Raneri F, Miller J, Lo Russo G. Implantation of Stereoelectroencephalography Electrodes: A Systematic Review. J Clin Neurophysiol. 2016 Dec;33(6):490-502. Review. PubMed PMID: 27918344
  • Ostergard T, Sweet J, Kusyk D, Herring E, Miller J. Animal models of post-traumatic epilepsy. J Neurosci Methods. 2016 Oct 15;272:50-55. doi: 10.1016/j.jneumeth.2016.03.023. Epub 2016 Apr 1. Review. PubMed PMID: 27044802.
  • Hayek SM, Sweet JA, Miller JP, Sayegh RR. Successful Management of Corneal Neuropathic Pain with Intrathecal Targeted Drug Delivery. Pain Med. 2016 Jul;17(7):1302-7. doi: 10.1093/pm/pnv058. Epub 2015 Dec 14. PubMed PMID: 26814286.
  • Park JT, Manjila SV, Tangen RB, Cohen ML, Shahid AM, Sweet JA, Tuxhorn IE, Miller JP. Tailored disconnection based on presurgical evidence in catastrophic epilepsy: report of 2 cases. J Neurosurg Pediatr. 2016 Jun;17(6):679-82. doi:
    10.3171/2015.11.PEDS15495. Epub 2016 Feb 12. PubMed PMID: 26870899.
  • Alonso F, Sweet J, Miller J. Speech mapping using depth electrodes: The “electric Wada”. Clin Neurol Neurosurg. 2016 May;144:88-90. doi: 10.1016/j.clineuro.2016.03.017. Epub 2016 Mar 25. PubMed PMID: 27035743.
  • Koubeissi MZ, Kahriman E, Fastenau P, Bailey C, Syed T, Amina S, Miller J, Munyon C, Tanner A, Karanec K, Tuxhorn I, Lüders H. Multiple hippocampal transections for intractable hippocampal epilepsy: Seizure outcome. Epilepsy Behav. 2016 May;58:86-90. doi: 10.1016/j.yebeh.2016.03.004. Epub 2016 Apr 8. PubMed PMID: 27064827.
  • Sayegh RR, Sweet JA, Miller JP, Hayek SM. Electrical Stimulation of the Trigeminal Ganglion and Intrathecal Drug Delivery Systems for the Management of Corneal Neuropathic Pain. Cornea. 2016 Apr;35(4):576-7. doi: 10.1097/ICO.0000000000000751. PubMed PMID: 26807903.
  • Sweet J, Badjatiya A, Tan D, Miller J. Paresthesia-Free High-Density Spinal Cord Stimulation for Postlaminectomy Syndrome in a Prescreened Population: A Prospective Case Series. Neuromodulation. 2016 Apr;19(3):260-7. doi: 10.1111/ner.12357. Epub 2015 Oct 20. PubMed PMID: 26481726.
  • Tan D, Tyler D, Sweet J, Miller J. Intensity Modulation: A Novel Approach to Percept Control in Spinal Cord Stimulation. Neuromodulation. 2016 Apr;19(3):254-9. doi: 10.1111/ner.12358. Epub 2015 Oct 19. PubMed PMID: 26479774.
  • Girgis F, Pace J, Sweet J, Miller JP. Hippocampal Neurophysiologic Changes after Mild Traumatic Brain Injury and Potential Neuromodulation Treatment Approaches. Front Syst Neurosci. 2016 Feb 9;10:8. doi: 10.3389/fnsys.2016.00008.  eCollection 2016. Review. PubMed PMID: 26903824; PubMed Central PMCID: PMC4746250.
  • Fastenau PS, Bailey CM, Sweet JA, Munyon CN, Lüders HO, Miller JP. Reply: The challenges for research on deep brain stimulation and memory. Brain. 2016 Feb;139(Pt 2):e13. doi: 10.1093/brain/awv295. Epub 2015 Oct 22. PubMed PMID: 26493636.
  • Suresh S, Sweet J, Fastenau PS, Lüders H, Landazuri P, Miller J. Temporal lobe epilepsy in patients with nonlesional MRI and normal memory: an SEEG study. J Neurosurg. 2015 Dec;123(6):1368-74. doi: 10.3171/2015.1.JNS141811. Epub 2015 Jul 24. PubMed PMID: 26207602.
  • Okoye CC, Patel RB, Hasan S, Podder T, Khouri A, Fabien J, Zhang Y, Dobbins D, Sohn JW, Yuan J, Yao M, Machtay M, Sloan AE, Miller J, Lo SS. Comparison of Ray Tracing and Monte Carlo Calculation Algorithms for Thoracic Spine Lesions Treated With CyberKnife-Based Stereotactic Body Radiation Therapy. Technol Cancer Res Treat. 2016 Feb;15(1):196-202. doi: 10.1177/1533034614568026. Epub 2015 Jan 28. PubMed PMID: 25633137.
  • Duan Y, Sweet J, Munyon C, Miller J. Degree of distal trigeminal nerve atrophy predicts outcome after microvascular decompression for Type 1a trigeminal neuralgia. J Neurosurg. 2015 Dec;123(6):1512-8. doi: 10.3171/2014.12.JNS142086. Epub 2015 Jul 17. PubMed PMID: 26186027.
  • Munyon C, Sweet J, Luders H, Lhatoo S, Miller J. The 3-dimensional grid: a novel approach to stereoelectroencephalography. Neurosurgery. 2015 Mar;11 Suppl 2:127-33; discussion 133-4. doi: 10.1227/NEU.0000000000000649. PubMed PMID: 25599199.
  • Sweet J, Eakin K, Munyon C, Miller J. Improved cognition with theta burst stimulation of the fornix in a rat model of traumatic brain injury. Hippocampus 2014 Dec;24(12):1592-600.
  • Munyon C, Sweet J, Luders H, Lhatoo S, Miller J. The 3-Dimensional Grid: A Novel Approach to Stereoelectroencephalography. Neurosurgery. 2015 Jan 16. [Epub ahead of print] PubMed PMID: 25599199.
  • Miller J, Sweet J, Bailey C, Munyon C, Luders H, Fastenau P. Memory for Complex Figures is enhanced with Theta Burst Deep Brain Stimulation of the Fornix. Brain 2015 (in press).
  • Munyon C, Eakin K, Sweet J, Miller J. Decreased bursting and novel object-specific cell firing in the hippocampus after mild traumatic brain injury. Brain Res 2014 Sep 25;1582:220-6.
  • Koubeissi MZ, Kahriman E, Syed TU, Miller J, Durand DM. Low-frequency electrical stimulation of a fiber tract in temporal lobe epilepsy. Ann Neurol. 2013 Aug;74(2):223-31. doi: 10.1002/ana.23915. Epub 2013 Sep 4. PubMed PMID: 23613463.
  • Wu S, Hariprasad K, Lhatoo S, Koubeissi M, Miller J, Luders H. Role of ictal direct current shifts and ictal high frequency oscillations in stereo-electroencephalography analysis of mesial temporal lobe seizures. Epilepsia 2014 May;55(5):690-8.


Research Programs:
  • Neurostimulation applications
  • Epileptogenic zone identification
  • Neurophysiological changes in brain injury
  • Neural interface technology


Contact Name: Jonathan Miller
Contact Number: (216 ) 844-3470
Contact Email: