Mehra, Reena, MD, MS

reena mehraResearch Statement

Dr. Mehra is a physician scientist with a longstanding commitment of ~15 years to the investigation of clinical and translational science of sleep disorders and cardiovascular disease utilizing epidemiologic and clinical trials methods. She is a board certified Pulmonary, Critical Care and Sleep Medicine physician with advanced Sleep Medicine Neurobiology and Epidemiology training via a NIH Ruth L. Kirschstein National Research Service Award and earned a Master of Science in Clinical Epidemiology.  She serves as an investigator on novel neurostimulation therapeutic interventions for the treatment of sleep disordered breathing such as hypoglossal nerve stimulation for obstructive sleep apnea and phrenic nerve stimulation for central sleep apnea.


Professional Affiliations

  • Investigator, Cleveland FES Center
  • Professor of Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
  • Director of Research, Sleep Disorders Center, Neurologic Institute, Cleveland Clinic, Cleveland, OH
  • Staff, Respiratory Institute, Cleveland Clinic, Cleveland, OH
  • Staff, Molecular Cardiology Department, Lerner Research Institute, Cleveland Clinic, Cleveland, OH
  • Staff, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH

Publications (Select)

  • Mehra R, Wang L, Andrews N, Tang WHW, Young JB, Javaheri S, Foldvary-Schaefer N. Dissociation of Objective and Subjective Daytime Sleepiness and Biomarkers of Systemic Inflammation in Sleep-Disordered Breathing and Systolic Heart Failure. J Clin Sleep Med. 2017 Dec 15;13(12):1411–1422. doi: 10.5664/jcsm.6836 Pubmed PMID: 29065958
  • Walia HK, Thompson NR, Katzan I, Foldvary-Schaefer N, Moul DE, Mehra R. Impact of Sleep-Disordered Breathing Treatment on Quality of Life Measures in a Large Clinic-Based Cohort. J Clin Sleep Med. 2017 Nov 15;13(11):1255–1263. doi: 10.5664/jcsm.6792 Pubmed PMID: 28992832
  • Mehra R. Sleep Apnea and Nocturnal Cardiac Arrhythmia: Understanding Differences Across Ethnicity. J Clin Sleep Med. 2017 Nov 15;13(11):1229–1231. doi: 10.5664/jcsm.6784 Pubmed PMID: 29065964
  • Kaw R, Mehra R. Sleep disordered breathing and post-cardiac surgery atrial fibrillation. J Thorac Dis. 2017 Sep;9(9):E867–E868. doi: 10.21037/jtd.2017.08.105 Pubmed PMID: 29221363
    Zhao YY, Mehra R. Biomarkers in Sleep Apnea and Heart Failure. Curr Heart Fail Rep. 2017 Aug;14(4):284–300. doi: 10.1007/s11897-017-0339-7 Pubmed PMID: 28667490
  • Tung P, Levitzky YS, Wang R, Weng J, Quan SF, Gottlieb DJ, Rueschman M, Punjabi NM, Mehra R, Bertisch S, Benjamin EJ, Redline S. Obstructive and Central Sleep Apnea and the Risk of Incident Atrial Fibrillation in a Community Cohort of Men and Women. J Am Heart Assoc. 2017 Jul 1;6(7). doi: 10.1161/JAHA.116.004500 Pubmed PMID: 28668820
  • Lewis EF, Wang R, Punjabi N, Gottlieb DJ, Quan SF, Bhatt DL, Patel SR, Mehra R, Blumenthal RS, Weng J, Rueschman M, Redline S. Impact of continuous positive airway pressure and oxygen on health status in patients with coronary heart disease, cardiovascular risk factors, and obstructive sleep apnea: A Heart Biomarker Evaluation in Apnea Treatment (HEARTBEAT) analysis. Am Heart J. 2017 Jul;189:59–67. doi: 10.1016/j.ahj.2017.03.001 Pubmed PMID: 28625382
  • Bernstein AM, Allexandre D, Bena J, Doyle J, Gendy G, Wang L, Fay S, Mehra R, Moul D, Foldvary-Schaefer N, Roizen MF, Drerup M. “Go! to Sleep”: A Web-Based Therapy for Insomnia. Telemed J E Health. 2017 Jul;23(7):590–599. doi: 10.1089/tmj.2016.0208 Pubmed PMID: 28112590
  • Xu B, Mehra R. The hemodynamic impact of acute nasal continuous positive airway pressure treatment in hypertrophic cardiomyopathy: is it safe? J Thorac Dis. 2017 Jun;9(6):1409–1411. doi: 10.21037/jtd.2017.05.20 Pubmed PMID: 28740644
  • Mehra R, Foldvary-Schaefer N. The USPSTF and screening for obstructive sleep apnea: Dispelling misconceptions. Cleve Clin J Med. 2017 Jun;84(6):429–431. doi: 10.3949/ccjm.84a.17023 Pubmed PMID: 28628426
  • Kaw R, El Zarif S, Wang L, Bena J, Blackstone EH, Mehra R. Obesity as an Effect Modifier in Sleep-Disordered Breathing and Postcardiac Surgery Atrial Fibrillation. Chest. 2017 Jun;151(6):1279–1287. doi: 10.1016/j.chest.2017.03.006 Pubmed PMID: 28300569
  • Mehra R, Bena J, Walia HK. Clarifying the Role of Hypoxia in Obstructive Sleep Apnea as a Potential Promulgator of Atrial Fibrillation in Ischemic Stroke. J Clin Sleep Med. 2017 May 15;13(5):667–668. doi: 10.5664/jcsm.6578 Pubmed PMID: 28416047
  • Raman D, Kaffashi F, Lui L-Y, Sauer WH, Redline S, Stone P, Cawthon PM, Stone KL, Ensrud KE, Ancoli-Israel S, Loparo K, Mehra R. Polysomnographic Heart Rate Variability Indices and Atrial Ectopy Associated with Incident Atrial Fibrillation Risk in Older Community-dwelling Men. JACC Clin Electrophysiol. 2017 May;3(5):451–460. doi: 10.1016/j.jacep.2016.09.001 Pubmed PMID: 28534047
  • Mehra R. Building Evidence Implicating Novel Cardiovascular Biomarkers in Obstructive Sleep Apnea. J Clin Sleep Med. 2017 Mar 15;13(3):361–362. doi: 10.5664/jcsm.6476 Pubmed PMID: 28212699
  • Kapur VK, Auckley DH, Chowdhuri S, Kuhlmann DC, Mehra R, Ramar K, Harrod CG. Clinical Practice Guideline for Diagnostic Testing for Adult Obstructive Sleep Apnea: An American Academy of Sleep Medicine Clinical Practice Guideline. J Clin Sleep Med. 2017 Mar 15;13(3):479–504. doi: 10.5664/jcsm.6506 Pubmed PMID: 28162150
  • Javaheri S, Barbe F, Campos-Rodriguez F, Dempsey JA, Khayat R, Javaheri S, Malhotra A, Martinez-Garcia MA, Mehra R, Pack AI, Polotsky VY, Redline S, Somers VK. Sleep Apnea: Types, Mechanisms, and Clinical Cardiovascular Consequences. J Am Coll Cardiol. 2017 Feb 21;69(7):841–858. doi: 10.1016/j.jacc.2016.11.069 Pubmed PMID: 28209226
  • May AM, Van Wagoner DR, Mehra R. OSA and Cardiac Arrhythmogenesis: Mechanistic Insights. Chest. 2017 Jan;151(1):225–241. doi: 10.1016/j.chest.2016.09.014 Pubmed PMID: 27693594

Contact Information

Contact Name: Reena Mehra
Contact Number: (216) 444-4946
Contact Email: mehrar@ccf.org