Megerian, Cliff, MD

Research Statement

Dr. Megerian is an expert for patients who need to manage hearing loss, chronic ear disease, cholesteoma, otosclerosis, vertigo, and countless other otology and neurotology issues.  He is also an expert in the diagnosis and treatment of acoustic neuroma. He has published over 120 peer reviewed manuscripts and abstracts and has served as visiting professor at numerous medical schools and institutions throughout the world.  His research interests in the pathogenesis of Meniere’s disease have been funded by a number of agencies including the NIH.

Professional Affiliations

  • Investigator, Cleveland FES Center
  • Chairman, Department of Otolaryngology Head and Neck Surgery, University Hospitals Cleveland Medical Center, Cleveland, OH
  • Chair, Auditory Surgery and Hearing Sciences, University Hospitals Cleveland Medical Center, Cleveland, OH
  • Professor, Otolaryngology, School of Medicine, Case Western Reserve University, Cleveland, OH
  • Director, Ear, Nose and Throat Institute, University Hospitals, Cleveland, OH
  • President, Physician Services, University Hospitals Cleveland Medical Center, Cleveland, OH

Publications (Select)

  • Ascha MS, Manzoor N, Gupta A, Semaan M, Megerian C, Otteson TD. Vestibular Aqueduct Midpoint Width and Hearing Loss in Patients With an Enlarged Vestibular Aqueduct. JAMA Otolaryngol Head Neck Surg. 2017 Mar 23. doi: 10.1001/jamaoto.2016.4522. [Epub ahead of print] PubMed PMID: 28334328.
  • Wick CC, Lin SJ, Yu H, Megerian CA, Zheng QY. Treatment of ear and bone disease in the Phex mouse mutant with dietary supplementation. Am J Otolaryngol. 2017 Jan – Feb;38(1):44-51. doi: 10.1016/j.amjoto.2016.09.014. Epub 2016 Sep 28.  PubMed PMID: 27733274.
  • Wick CC, Zachariah J, Manjila S, Brown WC, Malla P, Katirji B, Cohen M, Megerian CA. IgG4-related disease causing facial nerve and optic nerve palsies: Case report and literature review. Am J Otolaryngol. 2016 Nov – Dec;37(6):567-571. doi: 10.1016/j.amjoto.2016.08.005. Epub 2016 Aug 18. PubMed PMID: 27609186.
  • Manzoor NF, Ray A, Singer J, Nord R, Sunshine J, Megerian CA, Bambakidis NC, Semaan MT. Successful endovascular management of venous sinus thrombosis complicating trans-labyrinthine removal of vestibular schwanomma. Am J Otolaryngol. 2016 Jul-Aug;37(4):379-82. doi: 10.1016/j.amjoto.2016.01.018. Epub 2016 Feb 5. PubMed PMID: 27045766.
  • Nakashima T, Pyykkö I, Arroll MA, Casselbrant ML, Foster CA, Manzoor NF, Megerian CA, Naganawa S, Young YH. Meniere’s disease. Nat Rev Dis Primers. 2016 May 12;2:16028. doi: 10.1038/nrdp.2016.28. Review. PubMed PMID: 27170253.
  • Semaan MT, Wick CC, Kinder KJ, Stuyt JG, Chota RL, Megerian CA. Retrosigmoid versus translabyrinthine approach to acoustic neuroma resection: A comparative cost-effectiveness analysis. Laryngoscope. 2016 Feb;126 Suppl 3:S5-12. doi: 10.1002/lary.25729. Epub 2015 Oct 22. PubMed PMID: 26490680.
  • Manzoor NF, Wick CC, Wahba M, Gupta A, Piper R, Murray GS, Otteson T, Megerian CA, Semaan MT. Bilateral Sequential Cochlear Implantation in Patients With Enlarged Vestibular Aqueduct (EVA) Syndrome. Otol Neurotol. 2016 Feb;37(2):e96-103. doi: 10.1097/MAO.0000000000000925. PubMed PMID: 26756161.
  • Donovan C, Sweet J, Eccher M, Megerian C, Semaan M, Murray G, Miller J. Deep Brain Stimulation of Heschl Gyrus: Implantation Technique, Intraoperative Localization, and Effects of Stimulation. Neurosurgery. 2015 Dec;77(6):940-7. doi: 10.1227/NEU.0000000000000969. PubMed PMID: 26280116.
  • Li S, Hrisomalos EN, Semaan MT, Megerian CA. Ipsilateral single stage conversion from BAHA to cochlear implant. Am J Otolaryngol. 2015 Jun 1; doi: 10.1016/j.amjoto.2015.05.003 Pubmed PMID: 26119080
  • Wick CC, Manzoor NF, Semaan MT, Megerian CA. Endolymphatic Sac Tumors. Otolaryngol Clin North Am. 2015 Jan 30. pii: S0030-6665(14)00190-X. doi: 10.1016/j.otc.2014.12.006. [Epub ahead of print] Review. PubMed PMID: 25650230.
  • Rayess HM, Weng C, Murray GS, Megerian CA, Semaan MT. Predictive factors and outcomes of cochlear implantation in patients with connexin 26 mutation: a comparative study. Am J Otolaryngol. 2015 Jan-Feb;36(1):7-12. doi: 10.1016/j.amjoto.2014.08.010. Epub 2014 Aug 27. PubMed PMID: 25270357.
  • Wick CC, Semaan MT, Zheng QY, Megerian CA. A Genetic Murine Model of Endolymphatic Hydrops: The Phex Mouse. Curr Otorhinolaryngol Rep. 2014 Sep;2(3):144-151. PubMed PMID: 25309828; PubMed Central PMCID: PMC4193546
  • Melki SJ, Li Y, Semaan MT, Zheng QY, Megerian CA, Alagramam KN. A mouse model validates the utility of electrocochleography in verifying endolymphatic hydrops. J Assoc Res Otolaryngol. 2014 Jun;15(3):413-21. doi: 10.1007/s10162-014-0445-0. Epub 2014 Feb 8. PubMed PMID: 24509791; PubMed Central PMCID: PMC4010592.
  • Liu YC, Semaan MT, Rayess H, Megerian CA. Hearing and vertigo outcomes after congenital labyrinthine cholesteatoma resection. Am J Otolaryngol. 2014 May-Jun;35(3):417-23. doi: 10.1016/j.amjoto.2014.01.004. Epub 2014 Jan 10.Review. PubMed PMID: 24503247.
  • Karampelas I, Wick C, Semaan M, Megerian CA, Bambakidis NC. Translabyrinthine resection of small intracanalicular acoustic tumor. Neurosurg Focus. 2014 Jan;36(1 Suppl):1. doi: 10.3171/2014.V1.FOCUS13448. PubMed PMID: 24380528.
  • Xu F, Karampelas I, Megerian CA, Selman WR, Bambakidis NC. Petroclival meningiomas: an update on surgical approaches, decision making, and treatment results. Neurosurg Focus. 2013 Dec;35(6):E11. doi: 10.3171/2013.9.FOCUS13319. PubMed PMID: 24289119.
  • Manjila S, Wick CC, Cramer J, Semaan MT, Bambakidis NC, Selman WR, Megerian CA. Meningoencephalocele of the temporal bone: pictorial essay on transmastoid extradural-intracranial repair. Am J Otolaryngol. 2013 Nov-Dec;34(6):664-75. doi: 10.1016/j.amjoto.2013.05.004. Epub 2013 Jul 17. PubMed PMID: 23870755.
  • Semaan MT, Fredman ET, Shah JR, Fares SA, Murray GS, Megerian CA. Surgical duration of cochlear implantation in an academic university-based practice. Am J Otolaryngol. 2013 Sep-Oct;34(5):382-7. doi: 10.1016/j.amjoto.2013.01.013. Epub 2013 Feb 13. PubMed PMID: 23415572.
  • Manjila S, Weidenbecher M, Semaan MT, Megerian CA, Bambakidis NC. Prevention of postoperative cerebrospinal fluid leaks with multilayered reconstruction using titanium mesh-hydroxyapatite cement cranioplasty after translabyrinthine resection of acoustic neuroma. J Neurosurg. 2013 Jul;119(1):113-20. doi: 10.3171/2012.11.JNS121365. Epub 2013 Jan 25. PubMed PMID: 23350781.

Contact Information

Contact Name: Cliff Megerian
Contact Number: (216) 844-6000
Contact Email: Cliff.Megerian@UHhospitals.org