Walker, Mark, MD

Research Statement

My research focuses on the brain’s control of eye movements and vestibular reflexes for vision and balance. A particular focus is the neural control of the vestibular reflexes that respond to linear accelerations (head translations and gravity), the impairment of these reflexes in neurological diseases, and how such deficits affect balance and locomotion.

Professional Affiliations

  • Investigator, Cleveland FES Center
  • Staff Neurologist, Louis Stokes Cleveland VA Medical Center, Cleveland, OH
  • Associate Professor, Department of Neurology, Case Western Reserve University, Cleveland, OH
  • Investigator, APT Center
  • Director, Daroff-Dell’Osso Ocular Motility Laboratory, Louis Stokes Cleveland VA Medical Center, Cleveland, OH

Publications

  • Pan T, Liao K, Roenigk K, Daly JJ, Walker MF. Static and dynamic postural stability in veterans with combat-related mild traumatic brain injury. Gait Posture. 2015 Oct;42(4):550-7. doi: 10.1016/j.gaitpost.2015.08.012. Epub 2015 Sep 8. PubMed PMID: 26374930.
  • Ghasia FF, Shaikh AG, Jacobs J, Walker MF. Cross-coupled eye movement supports neural origin of pattern strabismus. Invest Ophthalmol Vis Sci. 2015 May;56(5):2855-66. doi: 10.1167/iovs.15-16371. PubMed PMID: 26024072; PubMed Central PMCID: PMC4419776.
  • Riechers RG, Walker MF, Ruff RL. Post-traumatic headaches. Handb Clin Neurol. 2015;128:567–578. doi: 10.1016/B978-0-444-63521-1.00036-4 Pubmed PMID: 25701908
  • Serra A, Skelly MM, Jacobs JB, Walker MF, Cohen JA. Improvement of internuclear ophthalmoparesis in multiple sclerosis with dalfampridine. Neurology. 2014 Jul 8;83(2):192–194. doi: 10.1212/WNL.0000000000000567 Pubmed PMID: 24907233
  • Schneider R, Walker MF. Amplitude and frequency prediction in the translational vestibulo-ocular reflex. J Vestib Res. 2014;24(5-6):357–364. doi: 10.3233/VES-140528 Pubmed PMID: 25564078
  • Schneider R, Liao K, Walker MF, Bronstein A, Leigh RJ. Behavior of the human translational vestibulo-ocular reflex during simultaneous head translation and rotation. J Vestib Res. 2014;24(5-6):329–333. doi: 10.3233/VES-140522 Pubmed PMID: 25564074
  • Alberts MJ, Wechsler LR, Jensen MEL, Latchaw RE, Crocco TJ, George MG, Baranski J, Bass RR, Ruff RL, Huang J, Mancini B, Gregory T, Gress D, Emr M, Warren M, Walker MD. Formation and function of acute stroke-ready hospitals within a stroke system of care recommendations from the brain attack coalition. Stroke. 2013 Dec;44(12):3382–3393. doi: 10.1161/STROKEAHA.113.002285 Pubmed PMID: 24222046
  • Walker MF, Tian J, Shan X, Tamargo RJ, Ying H, Zee DS. The cerebellar nodulus/uvula integrates otolith signals for the translational vestibulo-ocular reflex. PLoS ONE. 2010;5(11):e13981. doi: 10.1371/journal.pone.0013981 Pubmed PMID: 21085587
  • Liao K, Walker MF, Joshi AC, Reschke M, Strupp M, Wagner J, Leigh RJ. The linear vestibulo-ocular reflex, locomotion and falls in neurological disorders. Restor Neurol Neurosci. 2010;28(1):91–103. doi: 10.3233/RNN-2010-0507 Pubmed PMID: 20086286

Research Programs

  • Neural processing of vestibular signals for the control of eye movements and balance
  • Study of vestibular reflexes in neurological diseases
  • Mechanisms of imbalance after traumatic brain injury

Contact Information

Contact Name: Mark Walker
Contact Email: Mark.walker@case.edu