Lhatoo, Samden, MD, FRCP

Samden-Lhatoo-webResearch Statement

Dr. Lhatoo’s clinical and research interests are the investigation and management of refractory epilepsy; mortality of epilepsy with particular regard to sudden death in epilepsy (SUDEP)



Professional Affiliations

  • Investigator, Cleveland FES Center
  • Director, Epilepsy Center, University Hospitals Cleveland Medical Center, Cleveland, OH
  • Professor, Neurology, School of Medicine, Case Western Reserve University, Cleveland, OH

Publications (Select)

  • Shi J, Lacuey N, Lhatoo S. Surgical outcome of MRI-negative refractory extratemporal lobe epilepsy. Epilepsy Res. 2017 Apr 20;133:103-108. doi: 10.1016/j.eplepsyres.2017.04.010. [Epub ahead of print] PubMed PMID: 28477458.
  • Lacuey N, Zonjy B, Londono L, Lhatoo SD. Amygdala and hippocampus are symptomatogenic zones for central apneic seizures. Neurology. 2017 Feb 14;88(7):701-705. doi: 10.1212/WNL.0000000000003613. Epub 2017 Jan 13. PubMed PMID: 28087822; PubMed Central PMCID: PMC5317387.
  • Lhatoo S, Lacuey N, Ryvlin P. Principles of Stereotactic Electroencephalography in Epilepsy Surgery. J Clin Neurophysiol. 2016 Dec;33(6):478-482. Review. PubMed PMID: 26840984.
  • Devinsky O, Hesdorffer DC, Thurman DJ, Lhatoo S, Richerson G. Omega-3 fatty acids and SUDEP prevention – Authors’ reply. Lancet Neurol. 2016 Dec;15(13):1303-1304. doi: 10.1016/S1474-4422(16)30285-X. PubMed PMID: 27839639.
  • Sajatovic M, Tatsuoka C, Welter E, Perzynski AT, Colon-Zimmermann K, Van Doren JR, Bukach A, Lawless ME, Ryan ER, Sturniolo K, Lhatoo S. Targeted Self-Management of Epilepsy and Mental Illness for individuals with epilepsy and psychiatric comorbidity. Epilepsy Behav. 2016 Nov;64(Pt A):152-159. doi: 10.1016/j.yebeh.2016.08.012. Epub 2016 Oct 12. PubMed PMID: 27743547.
  • Munube D, Katabira E, Ndeezi G, Joloba M, Lhatoo S, Sajatovic M, Tumwine JK. Prevalence of stroke in children admitted with sickle cell anaemia to Mulago Hospital. BMC Neurol. 2016 Sep 17;16:175. doi: 10.1186/s12883-016-0704-2. PubMed PMID: 27639979; PubMed Central PMCID: PMC5026778.
  • Lhatoo S, Noebels J, Whittemore V, NINDS Center for SUDEP Research. Sudden unexpected death in epilepsy: Identifying risk and preventing mortality. Epilepsia. 2015 Nov;56(11):1700–1706. doi: 10.1111/epi.13134 Pubmed PMID: 26494436
  • Kaiboriboon K, Malkhachroum AM, Zrik A, Daif A, Schiltz NM, Labiner DM, Lhatoo SD. Epilepsy surgery in the United States: Analysis of data from the National Association of Epilepsy Centers. Epilepsy Res. 2015 Oct;116:105–109. doi: 10.1016/j.eplepsyres.2015.07.007 Pubmed PMID: 26310969
  • Sethi NK, Lhatoo SD, Nashef L, Tomson T, Ryvlin P, Mortality on Epilepsy Monitoring Units Study, Tao J, Liebenthal J, Wu S, Rose S, Ebersole JS. Association of prone position with sudden unexpected death in epilepsy. Neurology. 2015 Sep 29;85(13):1185–1186. doi: 10.1212/WNL.0000000000002011 Pubmed PMID: 26416803
  • Thom M, Michalak Z, Wright G, Dawson T, Hilton D, Joshi A, Diehl B, Koepp M, Lhatoo S, Sander JW, Sisodiya SM. Audit of practice in sudden unexpected death in epilepsy (SUDEP) post mortems and neuropathological findings. Neuropathol Appl Neurobiol. 2015 Aug 24; doi: 10.1111/nan.12265 Pubmed PMID: 26300477
  • Pestana Knight EM, Schiltz NK, Bakaki PM, Koroukian SM, Lhatoo SD, Kaiboriboon K. In response: Epilepsy surgery trends in the U.S.-Differences between kids and adults. Epilepsia. 2015 Aug;56(8):1321–1322. doi: 10.1111/epi.13058 Pubmed PMID: 26235740
  • Lacuey N, Davila JC, Zonjy B, Amina S, Couce M, Turnbull J, Miller J, Lüders H, Lhatoo SD. Lesion-negative anterior cingulate epilepsy. Epileptic Disord. 2015 Jun;17(2):134–142. doi: 10.1684/epd.2015.0749 Pubmed PMID: 26056053
  • Lacuey N, Zonjy B, Kahriman ES, Marashly A, Miller J, Lhatoo SD, Lüders HO. Homotopic reciprocal functional connectivity between anterior human insulae. Brain Struct Funct. 2015 May 21; doi: 10.1007/s00429-015-1065-0 Pubmed PMID: 25993901
  • Pestana Knight EM, Schiltz NK, Bakaki PM, Koroukian SM, Lhatoo SD, Kaiboriboon K. Increasing utilization of pediatric epilepsy surgery in the United States between 1997 and 2009. Epilepsia. 2015 Mar;56(3):375–381. doi: 10.1111/epi.12912 Pubmed PMID: 25630252
  • Munyon C, Sweet J, Luders H, Lhatoo S, Miller J. The 3-dimensional grid: a novel approach to stereoelectroencephalography. Neurosurgery. 2015 Mar;11 Suppl 2:127–133; discussion 133–134. doi: 10.1227/NEU.0000000000000649 Pubmed PMID: 25599199
  • Lüders H, Amina S, Eccher M, Devereaux M, Lhatoo S. Commentary: Should consciousness be used to describe seizures and what terms should be applied: Epilepsia’s survey results. Epilepsia. 2015 Mar;56(3):344. doi: 10.1111/epi.12921 Pubmed PMID: 25740046
  • Jayapandian C, Wei A, Ramesh P, Zonjy B, Lhatoo SD, Loparo K, Zhang G-Q, Sahoo SS. A scalable neuroinformatics data flow for electrophysiological signals using MapReduce. Front Neuroinform. 2015;9:4. doi: 10.3389/fninf.2015.00004 Pubmed PMID: 25852536

Contact Information

Contact Name: Samden Lhatoo
Contact Number: (216) 844-5855
Contact Email: samden.lhatoo@uhhospitals.org