Lewis, Stephen J, PhD

Research Interests

  • Physiology and pharmacology of the cardiovascular system
  • Physiology and pharmacology of breathing
  • Role of nitric oxide and Snitrosothiols in control of blood pressure and breathing
  • Role of sensory input to the control of blood pressure and breathing


Professional Affiliations

  • Investigator, Cleveland FES Center
  • Professor of Pediatrics and Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH

Publications (Select)

  • Stsiapura VI, Bederman I, Stepuro II, Morozkina TS, Lewis SJ, Smith L, Gaston B, Marozkina N. S-Nitrosoglutathione formation at gastric pH is augmented by ascorbic acid and by the antioxidant vitamin complex, Resiston. Pharm Biol. 2018  Dec;56(1):86-93. doi: 10.1080/13880209.2017.1421674. PubMed PMID: 29298528.
  • Baby SM, Gruber RB, Young AP, MacFarlane PM, Teppema LJ, Lewis SJ. Bilateral carotid sinus nerve transection exacerbates morphine-induced respiratory depression. Eur J Pharmacol. 2018 Jul 19;834:17-29. doi: 10.1016/j.ejphar.2018.07.018. [Epub ahead of print] PubMed PMID: 30012498.
  • Hsieh YH, Lewis SJ. The comings and goings of the vagus and the need to know your neural fulcrum. J Physiol. 2017 Nov 15;595(22):6809-6810. doi: 10.1113/JP275204. Epub 2017 Oct 19. PubMed PMID: 29052217; PubMed Central PMCID: PMC5685814.
  • Seckler JM, Meyer NM, Burton ST, Bates JN, Gaston B, Lewis SJ. Detection of trace concentrations of S-nitrosothiols by means of a capacitive sensor. PLoS One. 2017 Oct 26;12(10):e0187149. doi: 10.1371/journal.pone.0187149. eCollection 2017. PubMed PMID: 29073241; PubMed Central PMCID: PMC5658150.
  • Sivakumar SS, Namath AG, Tuxhorn IE, Lewis SJ, Galan RF. Decreased heart rate  and enhanced sinus arrhythmia during interictal sleep demonstrate autonomic imbalance in generalized epilepsy. J Neurophysiol. 2016 Feb 17:jn.01120.2015. doi: 10.1152/jn.01120.2015. [Epub ahead of print] PubMed PMID: 26888110.
  • Brognara F, Dias DP, Castania JA, Fazan R Jr, Lewis SJ, Salgado HC. Cardiovascular responses elicited by continuous versus intermittent electrical stimulation of the aortic depressor nerve in conscious rats. Life Sci. 2016 Feb 11. pii: S0024-3205(16)30076-5. doi: 10.1016/j.lfs.2016.02.033. [Epub ahead of print] PubMed PMID: 26876918.
  • Zaman K, Sawczak V, Zaidi A, Butler M, Bennett D, Getsy P, Zeinomar M, Greenberg Z, Forbes M, Rehman S, Jyothikumar V, DeRonde K, Sattar A, Smith L, Corey D, Straub A, Sun F, Palmer L, Periasamy A, Randell S, Kelley TJ, Lewis SJ,  Gaston B. Augmentation of CFTR maturation by S-nitrosoglutathione reductase. Am J Physiol Lung Cell Mol Physiol. 2016 Feb 1;310(3):L263-70. doi: 10.1152/ajplung.00269.2014. Epub 2015 Dec 4. PubMed PMID: 26637637.
  • Marozkina NV, Wang XQ, Stsiapura V, Fitzpatrick A, Carraro S, Hawkins GA, Bleecker E, Meyers D, Jarjour N, Fain SB, Wenzel S, Busse W, Castro M, Panettieri RA Jr, Moore W, Lewis SJ, Palmer LA, Altes T, de Lange EE, Erzurum S, Teague WG,  Gaston B. Phenotype of asthmatics with increased airway S-nitrosoglutathione reductase activity. Eur Respir J. 2015 Jan;45(1):87-97. doi: 10.1183/09031936.00042414. Epub 2014 Oct 30. Erratum in: Eur Respir J. 2015 Jun;45(6):1763. PubMed PMID: 25359343; PubMed Central PMCID: PMC4283933.

Research Programs

Contact Information

Contact Name: Stephen Lewis
Contact Number: (216) 368-3482
Contact Email: sjl78@case.edu