Chae, John, MD

Research Statement

My research interests are in the areas of post-stroke, upper and lower limb motor and functional restoration, and shoulder pain in hemiplegia. My active projects include the investigation of:

  • Various forms of electrical stimulation for upper limb motor relearning
  • Peroneal nerve stimulation for motor relearning and neuroprosthetic effects
  • Implanted neuroprostheses for upper and lower limb motor restoration
  • Implanted and surface stimulation for reduction of shoulder pain

Professional Affiliations

  • Investigator, Cleveland FES Center
  • Director, MetroHealth Rehabilitation Institute of Ohio, MetroHealth Old Brooklyn Health Center, Cleveland, OH
  • Professor and Chair, Physical Medicine and Rehabilitation; Professor, Biomedical Engineering, Case Western Reserve University, Cleveland, OH

Publications (Select)

  • Wilson RD, Bennett ME, Nguyen VQC, Bock WC, O’Dell MW, Watanabe TK, Amundson RH, Hoyen HA, Chae J. Fully Implantable Peripheral Nerve Stimulation for Hemiplegic Shoulder Pain: A Multi-Site Case Series With Two-Year Follow-Up. Neuromodulation. 2018 Apr;21(3):290–295. doi: 10.1111/ner.12726 Pubmed PMID: 29164745
  • Shellock FG, Zare A, Ilfeld BM, Chae J, Strother RB. In Vitro Magnetic Resonance Imaging Evaluation of Fragmented, Open-Coil, Percutaneous Peripheral Nerve Stimulation Leads. Neuromodulation. 2018 Apr;21(3):276–283. doi: 10.1111/ner.12705 Pubmed PMID: 29057550
  • Mehech D, Mejia M, Nemunaitis GA, Chae J, Wilson RD. Percutaneous peripheral nerve stimulation for treatment of shoulder pain after spinal cord injury: A case report. J Spinal Cord Med. 2017 Mar 17:1-5. doi: 10.1080/10790268.2017.1293329. [Epub ahead of print] PubMed PMID: 28303761.
  • Kapural L, Gilmore CA, Chae J, Rauck RL, Cohen SP, Saulino MF, Wongsarnpigoon A, McGee MJ, Boggs JW. Percutaneous Peripheral Nerve Stimulation for the Treatment of Chronic Low Back Pain: Two Clinical Case Reports of Sustained Pain Relief. Pain Pract. 2017 Mar 14. doi: 10.1111/papr.12571. [Epub ahead of print] PubMed PMID: 28296137.
  • Wilson RD, Knutson JS, Bennett ME, Chae J. The Effect of Peripheral Nerve Stimulation on Shoulder Biomechanics: A Randomized Controlled Trial in Comparison to Physical Therapy. Am J Phys Med Rehabil. 2017 Mar;96(3):191-198. doi: 10.1097/PHM.0000000000000677. PubMed PMID: 28099193; PubMed Central PMCID: PMC5321785.
  • Ilfeld BM, Grant SA, Gilmore CA, Chae J, Wilson RD, Wongsarnpigoon A, Boggs JW. Neurostimulation for Postsurgical Analgesia: A Novel System Enabling Ultrasound-Guided Percutaneous Peripheral Nerve Stimulation. Pain Pract. 2016 Dec 2. doi: 10.1111/papr.12539. [Epub ahead of print] PubMed PMID: 27910257.
  • Wilson RD, Page SJ, Delahanty M, Knutson JS, Gunzler DD, Sheffler LR, Chae J. Upper-Limb Recovery After Stroke: A Randomized Controlled Trial Comparing EMG-Triggered, Cyclic, and Sensory Electrical Stimulation. Neurorehabil Neural Repair. 2016 Nov;30(10):978-987. Epub 2016 May 24. PubMed PMID: 27225977; PubMed Central PMCID: PMC5048487.
  • Knutson JS, Gunzler DD, Wilson RD, Chae J. Contralaterally Controlled Functional Electrical Stimulation Improves Hand Dexterity in Chronic Hemiparesis: A Randomized Trial. Stroke. 2016 Oct;47(10):2596-602. doi: 10.1161/STROKEAHA.116.013791. Epub 2016 Sep 8. PubMed PMID: 27608819; PubMed Central PMCID: PMC5039083.
  • Ilfeld BM, Gabriel RA, Saulino MF, Chae J, Peckham PH, Grant SA, Gilmore CA, Donohue MC, deBock MG, Wongsarnpigoon A, Boggs JW. Infection Rates of Electrical Leads Used for Percutaneous Neurostimulation of the Peripheral Nervous System. Pain Pract. 2016 Sep 27. doi: 10.1111/papr.12523. [Epub ahead of print] PubMed PMID: 27676323; PubMed Central PMCID: PMC5368033.
  • Chae J, Celnik PA. Stroke Rehabilitation. Phys Med Rehabil Clin N Am. 2015 Nov;26(4):xv-xvi. doi: 10.1016/j.pmr.2015.08.013. PubMed PMID: 26522913.
  • Fu MJ, Knutson JS, Chae J. Stroke Rehabilitation Using Virtual Environments. Phys Med Rehabil Clin N Am. 2015 Nov;26(4):747-57. doi: 10.1016/j.pmr.2015.06.001. Epub 2015 Aug 1. Review. PubMed PMID: 26522910; PubMed Central PMCID: PMC4630676.
  • Knutson JS, Fu MJ, Sheffler LR, Chae J. Neuromuscular Electrical Stimulation for Motor Restoration in Hemiplegia. Phys Med Rehabil Clin N Am. 2015 Nov;26(4):729-45. doi: 10.1016/j.pmr.2015.06.002. Epub 2015 Aug 14. Review. PubMed PMID: 26522909; PubMed Central PMCID: PMC4630679.
  • Wilson RD, Chae J. Hemiplegic Shoulder Pain. Phys Med Rehabil Clin N Am. 2015 Nov;26(4):641-55. doi: 10.1016/j.pmr.2015.06.007. Epub 2015 Sep 9. Review. PubMed PMID: 26522903.
  • Jeyaseelan RD, Vargo MM, Chae J. National Institutes of Health Stroke Scale (NIHSS) as An Early Predictor of Poststroke Dysphagia. PM R. 2015 Jun;7(6):593–598. doi: 10.1016/j.pmrj.2014.12.007 Pubmed PMID: 25556573
  • Sheffler LR, Taylor PN, Bailey SN, Gunzler DD, Buurke JH, IJzerman MJ, Chae J. Surface Peroneal Nerve Stimulation in Lower Limb Hemiparesis: Effect on Quantitative Gait Parameters. Am J Phys Med Rehabil. 2015 Mar 24. [Epub ahead of print] PubMed PMID: 25802966.
  • Makowski NS, Knutson JS, Chae J, Crago PE. Control of robotic assistance using poststroke residual voluntary effort. IEEE Trans Neural Syst Rehabil Eng. 2015 Mar;23(2):221-31. doi: 10.1109/TNSRE.2014.2364273. Epub 2014 Oct 31. PubMed PMID: 25373107.
  • Nguyen VQ, Bock WC, Groves CC, Whitney M, Bennett ME, Lechman TE, Strother R, Grill JH, Stager KW, Chae J. Fully implantable peripheral nerve stimulation for the treatment of hemiplegic shoulder pain: a case report. Am J Phys Med Rehabil. 2015 Feb;94(2):146-53. doi: 10.1097/PHM.0000000000000173. PubMed PMID: 25251248; PubMed Central PMCID: PMC4289017.
  • Jeyaseelan RD, Vargo MM, Chae J. National Institutes of Health Stroke Scale (NIHSS) as An Early Predictor of Poststroke Dysphagia. PM R. 2014 Dec 31. pii: S1934-1482(14)01557-3. doi: 10.1016/j.pmrj.2014.12.007. [Epub ahead of print] PubMed PMID: 25556573.
  • Wilson RD, Harris MA, Gunzler DD, Bennett ME, Chae J. Percutaneous peripheral nerve stimulation for chronic pain in subacromial impingement syndrome: a case series. Neuromodulation. 2014 Dec;17(8):771-6; discussion 776. doi: 10.1111/ner.12152. Epub 2014 Feb 11. PubMed PMID: 24512114; PubMed Central PMCID: PMC4128958.
  • Sheffler LR, Bailey SN, Gunzler D, Chae J. Effect of body mass index on hemiparetic gait. PM R. 2014 Oct;6(10):908-13. doi: 10.1016/j.pmrj.2014.03.012. Epub 2014 Apr 5. PubMed PMID: 24713181; PubMed Central PMCID: PMC4185303.
  • Knutson JS, Harley MY, Hisel TZ, Makowski NS, Chae J. Contralaterally controlled functional electrical stimulation for recovery of elbow extension and hand opening after stroke: a pilot case series study. Am J Phys Med Rehabil. 2014 Jun;93(6):528-39. doi: 10.1097/PHM.0000000000000066. PubMed PMID: 24508938; PubMed Central PMCID: PMC4029922.
  • Makowski NS, Knutson JS, Chae J, Crago PE. Functional electrical stimulation to augment poststroke reach and hand opening in the presence of voluntary effort: a pilot study. Neurorehabil Neural Repair. 2014 Mar-Apr;28(3):241-9. doi: 10.1177/1545968313505913. Epub 2013 Nov 22. PubMed PMID: 24270058; PubMed Central PMCID: PMC4128408.
  • Wilson RD, Gunzler DD, Bennett ME, Chae J. Peripheral nerve stimulation compared with usual care for pain relief of hemiplegic shoulder pain: a randomized controlled trial. Am J Phys Med Rehabil. 2014 Jan;93(1):17-28. doi: 10.1097/PHM.0000000000000011. PubMed PMID: 24355994; PubMed Central PMCID: PMC4038163.
  • Weaver LL, Page SJ, Sheffler L, Chae J. Minimal depression: how does it relate to upper-extremity impairment and function in stroke? Am J Occup Ther. 2013 Sep-Oct;67(5):550-5. doi: 10.5014/ajot.2013.008391. PubMed PMID: 23968793; PubMed Central PMCID: PMC3750124.

 Research Programs

  • Clinical Trials in Stroke Rehabilitation
  • Electrical stimulation for upper limb recovery in hemiplegia
  • FES for Footdrop in Hemiparesis
  • Percutaneous Electrical Nerve Stimulation for Hemiplegic Shoulder Pain

Contact Information

Contact Name: Sabrina Perkins
Contact Number: (216) 957-3623
Contact Email: