Durand, Dominique, PhD

Research Statement

Dr. Durand’s research interests are in neural engineering and include computational neuroscience, neurophysiology and control of epilepsy, non-linear dynamics of neural systems, neural prostheses and applied magnetic and electrical field interactions with neural tissue.


Professional Affiliations

  • Investigator, Cleveland FES Center
  • EL Lindseth Professor of Biomedical Engineering, Case Western Reserve University, Cleveland, OH
  • Departments of Biomedical Engineering, Neurosciences, Physiology and Biophysics, Case Western Reserve University, Cleveland, OH
  • Director, Neural Engineering Center, Case Western Reserve University, Cleveland, OH
  • Editor in chief, Journal of Neural Engineering, Case Western Reserve University, Cleveland, OH



Publications (Select)

  • Chiang C-C, Wei X, Ananthakrishnan AK, Shivacharan RS, Gonzalez-Reyes LE, Zhang M, Durand DMSlow moving neural source in the epileptic hippocampus can mimic progression of human seizures. Sci Rep. 2018 Jan 24;8(1):1564. doi: 10.1038/s41598-018-19925-7 Pubmed PMID: 29367722
  • Eggers TE, Dweiri YM, McCallum GA, Durand DMModel-based Bayesian signal extraction algorithm for peripheral nerves. J Neural Eng. 2017 Oct;14(5):056009. doi: 10.1088/1741-2552/aa7d94 Pubmed PMID: 28675376
  • Feng Z, Wang Z, Guo Z, Zhou W, Cai Z, Durand DM. High frequency stimulation of afferent fibers generates asynchronous firing in the downstream neurons in hippocampus through partial block of axonal conduction. Brain Res. 2017 Apr 15;1661:67-78. doi: 10.1016/j.brainres.2017.02.008. Epub 2017 Feb 14. PubMed PMID: 28213155.
  • Zhang M, Shivacharan RS, Chiang CC, Gonzalez-Reyes LE, Durand DM. Propagating Neural Source Revealed by Doppler Shift of Population Spiking Frequency. J Neurosci. 2016 Mar 23;36(12):3495-505. doi: 10.1523/JNEUROSCI.3525-15.2016. PubMed PMID: 27013678; PubMed Central PMCID: PMC4804007.
  • Qiu C, Shivacharan RS, Zhang M, Durand DM. Can Neural Activity Propagate by Endogenous Electrical Field? J Neurosci. 2015 Dec 2;35(48):15800-11. doi: 10.1523/JNEUROSCI.1045-15.2015. PubMed PMID: 26631463; PubMed Central PMCID: PMC4666910.
  • Park HJ, Durand DM. Motion control of the rabbit ankle joint with a flat interface nerve electrode. Muscle Nerve. 2015 Dec;52(6):1088-95. doi: 10.1002/mus.24654. Epub 2015 Sep 7. PubMed PMID: 25786911; PubMed Central PMCID:  PMC4575232.
  • Dweiri YM, Eggers T, McCallum G, Durand DM. Ultra-low noise miniaturized neural amplifier with hardware averaging. J Neural Eng. 2015 Aug;12(4):046024. doi: 10.1088/1741-2560/12/4/046024. Epub 2015 Jun 17. PubMed PMID: 26083774.
  • Ladas TP, Chiang CC, Gonzalez-Reyes LE, Nowak T, Durand DM. Seizure reduction through interneuron-mediated entrainment using low frequency optical stimulation. Exp Neurol. 2015 Jul;269:120-32. doi: 10.1016/j.expneurol.2015.04.001. Epub 2015 Apr 8. PubMed PMID: 25863022; PubMed Central PMCID: PMC4446206.
  • Chiang CC, Ladas TP, Gonzalez-Reyes LE, Durand DM. Seizure suppression by high frequency optogenetic stimulation using in vitro and in vivo animal models of epilepsy. Brain Stimul. 2014 Nov-Dec;7(6):890-9. doi: 10.1016/j.brs.2014.07.034.  Epub 2014 Jul 19. PubMed PMID: 25108607; PubMed Central PMCID: PMC4259846.
  • Feng Z, Yu Y, Guo Z, Cao J, Durand DM. High frequency stimulation extends the refractory period and generates axonal block in the rat hippocampus. Brain Stimul. 2014 Sep-Oct;7(5):680-9. doi: 10.1016/j.brs.2014.03.011. Epub 2014 Apr 4. PubMed PMID: 24938914; PubMed Central PMCID: PMC4167911.
  • Park HJ, Durand DM. Motion control of the ankle joint with a multiple contact nerve cuff electrode: a simulation study. Biol Cybern. 2014 Aug;108(4):445-57. doi: 10.1007/s00422-014-0612-8. Epub 2014 Jun 18. PubMed PMID: 24939581.
  • Durand DM, Ghovanloo M, Krames E. Time to address the problems at the neural interface. J Neural Eng. 2014 Apr;11(2):020201. doi: 10.1088/1741-2560/11/2/020201. Epub 2014 Feb 6. PubMed PMID: 24503546.
  • Zhang M, Ladas TP, Qiu C, Shivacharan RS, Gonzalez-Reyes LE, Durand DMPropagation of epileptiform activity can be independent of synaptic transmission, gap junctions, or diffusion and is consistent with electrical field transmission. J Neurosci. 2014 Jan 22;34(4):1409-19. doi: 10.1523/JNEUROSCI.3877-13.2014. PubMed PMID: 24453330; PubMed Central PMCID: PMC3898297.
  • Wang Y, Toprani S, Tang Y, Vrabec T, Durand DM. Mechanism of highly synchronized bilateral hippocampal activity. Exp Neurol. 2014 Jan;251:101-11. doi: 10.1016/j.expneurol.2013.11.014. Epub 2013 Nov 19. PubMed PMID: 24262205; PubMed Central PMCID: PMC3902113.
  • Tang Y, Wodlinger B, Durand DM. An algorithm for source signal extraction from the peripheral nerve. Conf Proc IEEE Eng Med Biol Soc. 2011;2011:4251–4254. doi: 10.1109/IEMBS.2011.6091055 Pubmed PMID: 22255278
  • Lee S, Ryu K, Waldo AL, Khrestian CM, Durand DM, Sahadevan J. An algorithm to measure beat-to-beat cycle lengths for assessment of atrial electrogram rate and regularity during atrial fibrillation. J Cardiovasc Electrophysiol. 2013 Feb;24(2):199–206. doi: 10.1111/jce.12014 Pubmed PMID: 23140386

Contact Information

Contact Name: Dominique Durand
Contact Number: (216) 368-3974
Contact Email: dxd6@case.edu