Capadona, Jeffrey, PhD

Capadona-webResearch Statement

My Lab is studying various aspects of microelectrode performance, and pursuing both materials-based and therapeutic-mediated methods to mitigate the inflammatory-mediated microelectrode failure mechanisms. My group has made significant contributions to this field, including our work describing the roles of oxidative stress, innate immunity pathways, tissue/device mechanical mismatch, device sterility (endotoxin contamination), and the contribution of local versus infiltrating inflammatory cells in mediating the neuroinflammatory response to intracortical microelectrodes. Since beginning a tenure track appoint at Case Western Reserve University in 2010, I have generated invention disclosures, patent filings, and over $5.6 M PI, $12.5 M total in new investigator-initiated projects sponsored by the NIH and Department of Veteran Affairs.  The impact of this work is evident in the high quality of journals we repeatedly publish in, the citations to that work, invitations to seminars (local to international), invited review articles and book chapters, as well as international media coverage of our work.

For more information on Dr. Capadona’s research, visit his lab website


 Professional Affiliations

  • Investigator, Cleveland FES Center
  • Research Health Scientist, Louis Stokes VA Medical Center, Cleveland, OH
  • Associate Professor, Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH

 Publications (Select)

  • Kovach KM, Kumsa DW, Srivastava V, Hudak EM, Untereker DF, Kelley SC, von Recum HA, Capadona JR. High-throughput in vitro assay to evaluate the cytotoxicity of liberated platinum compounds for stimulating neural electrodes. J Neurosci Methods. 2016 Nov 1;273:1-9. doi: 10.1016/j.jneumeth.2016.07.018. Epub 2016 Jul 30. PubMed PMID: 27485087.
  • Knothe Tate ML, Detamore M, Capadona JR, Woolley A, Knothe U. Engineering and commercialization of human-device interfaces, from bone to brain. Biomaterials. 2016 Jul;95:35-46. doi: 10.1016/j.biomaterials.2016.03.038. Epub 2016 Apr 13. Review. PubMed PMID: 27108404.
  • J.K. Nguyen, M. Jorfi, K.L. Buchanan, D.J. Park, E.J Foster, D.J. Tyler, S.J. Rowan, C. Weder, J.R. Capadona. Influence of resveratrol release on the tissue response to mechanically adaptive cortical implants.” Acta Biomaterialia; 2016, 29, 81-93.
  • K.A. Potter-Baker, W.G. Stewart, W.H. Tomaszewski, W.D. Meador, C.T. Wong, N.P. Ziats, J.R. Capadona. “Implications of Chronic Daily Anti-Oxidant Administration on the Inflammatory Response to Intracortical Microelectrodes.” Journal of Neural Eng. 2015, 12, 046002.
  • A.Sridharan, J.K. Nguyen, J.R. Capadona, and J. Muthuswamy. “Compliant Intracortical Implants Reduce Strains and Strain Rates in Brain Tissue In Vivo.” Journal of Neural Eng. 2015, 12, 036002.
  • K.A. Potter-Baker*, J.R. Capadona. “Reducing the “Stress”: Anti-oxidative Approaches Just May Prevent Abiotic and Biotic Failure Modes of Intracortical Microelectrodes.” ACS Macro Letters 2015, 4 (3), 275-279.
  • K. Kovach, M.A. Labarbera, M.C. Moyer, B.L. Cmolik, E. Van Lunteren, A. Sen Gupta, J.R. Capadona, J. Potkay. “In Vitro and In Vivo Evaluation of a Biomimetic, Hemocompatible, Microfluidic Artificial Lung.” Lab on a Chip 2015, 15, 1366-1376.
  • M. Jorfi#, J.L. Skousen#, C. Weder, J.R. Capadona. “Progress Towards Biocompatible Intracortical Microelectrodes for Neural Interfacing Applications.” Invited Topical Review for Journal of Neural Engineering 2015, 12, 011001. (# = denotes equal first authorship)

Contact Information

Contact Name: Jeffrey Capadona
Contact Number: (216) 368-5486
Contact Email: