Calabrese, Joseph, MD

Research Statement

Research interests include improvement of clinical outcomes in under-served populations of bipolar disorder, including those with rapid cycling, children and adolescents, adults currently abusing alcohol and/or drugs, forensic complications of bipolar disorder, those receiving care within community mental health centers, older adults, and members of the Ohio national guard and reserve.

Professional Affiliations

  • Investigator, Cleveland FES Center
  • Director, Mood Disorders Program, University Hospitals Cleveland Medical Center, Cleveland, OH
  • Bipolar Disorders Research Chair & Professor of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, OH

Publications (Select)

  • Calabrese JR, Jin N, Johnson B, Such P, Baker RA, Madera J, Hertel P, Ottinger J, Amatniek J, Kawasaki H. Aripiprazole once-monthly as maintenance treatment for bipolar I disorder: a. Int J Bipolar Disord. 2018 Jun 10;6(1):14. doi: 10.1186/s40345-018-0122-z Pubmed PMID: 29886522
  • Vieta E, Berk M, Schulze TG, Carvalho AF, Suppes T, Calabrese JR, Gao K, Miskowiak KW, Grande I. Bipolar disorders. Nat Rev Dis Primers. 2018 Mar 8;4:18008. doi: 10.1038/nrdp.2018.8 Pubmed PMID: 29516993
  • Yatham LN, Kennedy SH, Parikh SV, Schaffer A, Bond DJ, Frey BN, Sharma V, Goldstein BI, Rej S, Beaulieu S, Alda M, MacQueen G, Milev RV, Ravindran A, O’Donovan C, McIntosh D, Lam RW, Vazquez G, Kapczinski F, McIntyre RS, Kozicky J, Kanba S, Lafer B, Suppes T, Calabrese JR, Vieta E, Malhi G, Post RM, Berk M. Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder. Bipolar Disord. 2018 Mar;20(2):97–170. doi: 10.1111/bdi.12609 Pubmed PMID: 29536616
  • Calabrese JR, Sanchez R, Jin N, Amatniek J, Cox K, Johnson B, Perry P, Hertel P, Such P, McQuade RD, Nyilas M, Carson WH. Symptoms and functioning with aripiprazole once-monthly injection as maintenance treatment for bipolar I disorder. J Affect Disord. 2018 Feb;227:649–656. doi: 10.1016/j.jad.2017.10.035 Pubmed PMID: 29174738
  • Tohen M, Gold AK, Sylvia LG, Montana RE, McElroy SL, Thase ME, Rabideau DJ, Nierenberg AA, Reilly-Harrington NA, Friedman ES, Shelton RC, Bowden CL, Singh V, Deckersbach T, Ketter TA, Calabrese JR, Bobo WV, McInnis MG. Corrigendum to bipolar mixed features – Results from the comparative effectiveness for bipolar disorder (Bipolar CHOICE) study [Journal of Affective Disorders 217 (2017) 183-189]. J Affect Disord. 2018 Jan 1;225:775–777. doi: 10.1016/j.jad.2017.08.032 Pubmed PMID: 28826887
  • Sylvia LG, Chang WC, Kamali M, Tohen M, Kinrys G, Deckersbach T, Calabrese JR, Thase ME, Reilly-Harrington N, Bobo WV, Kocsis JH, McInnis MG, Bowden CL, Ketter TA, Friedman ES, Shelton RC, McElroy SL, Gao K, Rabideau DJ, Nierenberg AA. Sleep disturbance may impact treatment outcome in bipolar disorder: A preliminary investigation in the context of a large comparative effectiveness trial. J Affect Disord. 2018 Jan 1;225:563–568. doi: 10.1016/j.jad.2017.08.056 Pubmed PMID: 28881294
  • Kohler-Forsberg O, Madsen T, Behrendt-Moller I, Sylvia L, Bowden CL, Gao K, Bobo WV, Trivedi MH, Calabrese JR, Thase M, Shelton RC, McInnis M, Tohen M, Ketter TA, Friedman ES, Deckersbach T, McElroy SL, Reilly-Harrington NA, Nierenberg AA. Trajectories of suicidal ideation over 6 months among 482 outpatients with bipolar disorder. J Affect Disord. 2017 Dec 1;223:146–152. doi: 10.1016/j.jad.2017.07.038 Pubmed PMID: 28755622
  • Findling RL, Youngstrom EA, Rowles BM, Deyling E, Lingler J, Stansbrey RJ, McVoy M, Lytle S, Calabrese JR, McNamara NK. A Double-Blind and Placebo-Controlled Trial of Aripiprazole in Symptomatic Youths at Genetic High Risk for Bipolar Disorder. J Child Adolesc Psychopharmacol. 2017 Dec;27(10):864–874. doi: 10.1089/cap.2016.0160 Pubmed PMID: 28759262
  • Caldieraro MA, Walsh S, Deckersbach T, Bobo WV, Gao K, Ketter TA, Shelton RC, Reilly-Harrington NA, Tohen M, Calabrese JR, Thase ME, Kocsis JH, Sylvia LG, Nierenberg AA. Decreased activation and subsyndromal manic symptoms predict lower remission rates in bipolar depression. Aust N Z J Psychiatry. 2017 Nov 1;4867417741982. doi: 10.1177/0004867417741982 Pubmed PMID: 29143534
  • Mahableshwarkar AR, Calabrese JR, Macek TA, Budur K, Adefuye A, Dong X, Hanson E, Sachs GS. Efficacy and safety of sublingual ramelteon as an adjunctive therapy in the maintenance treatment of bipolar I disorder in adults: A phase 3, randomized controlled trial. J Affect Disord. 2017 Oct 15;221:275–282. doi: 10.1016/j.jad.2017.06.044 Pubmed PMID: 28662460
  • Calabrese JR, Pikalov A, Streicher C, Cucchiaro J, Mao Y, Loebel A. Lurasidone in combination with lithium or valproate for the maintenance treatment of bipolar I disorder. Eur Neuropsychopharmacol. 2017 Sep;27(9):865–876. doi: 10.1016/j.euroneuro.2017.06.013 Pubmed PMID: 28689688
  • Fink DS, Keyes KM, Calabrese JR, Liberzon I, Tamburrino MB, Cohen GH, Sampson L, Galea S. Deployment and Alcohol Use in a Military Cohort: Use of Combined Methods to Account for Exposure-Related Covariates and Heterogeneous Response to Exposure. Am J Epidemiol. 2017 May 6. doi: 10.1093/aje/kww230. [Epub ahead of print] PubMed PMID: 28482012.
  • Tohen M, Gold AK, Sylvia LG, Montana RE, McElroy SL, Thase ME, Rabideau DJ, Nierenberg AA, Reilly-Harrington NA, Friedman ES, Shelton RC, Bowden CL, Singh V, Deckersbach T, Ketter TA, Calabrese JR, Bobo WV, McInnis MG. Bipolar mixed features – Results from the comparative effectiveness for bipolar disorder (Bipolar CHOICE) study. J Affect Disord. 2017 Apr 5;217:183-189. doi: 10.1016/j.jad.2017.03.070. [Epub ahead of print] PubMed PMID: 28411507.
  • Köhler O, Sylvia LG, Bowden CL, Calabrese JR, Thase M, Shelton RC, McInnis M, Tohen M, Kocsis JH, Ketter TA, Friedman ES, Deckersbach T, Ostacher MJ, Iosifescu DV, McElroy S, Nierenberg AA. White blood cell count correlates with mood symptom severity and specific mood symptoms in bipolar disorder. Aust N Z J Psychiatry. 2017 Apr;51(4):355-365. doi: 10.1177/0004867416644508. Epub 2016 Jul 11. PubMed PMID: 27126391.
  • Fang F, Wang Z, Wu R, Calabrese JR, Gao K. Is there a ‘weight neutral’ second-generation antipsychotic for bipolar disorder? Expert Rev Neurother. 2017 Apr;17(4):407-418. doi: 10.1080/14737175.2016.1276284. Epub 2017 Jan 2. PubMed PMID: 28005435.
  • Caldieraro MA, Sylvia LG, Dufour S, Walsh S, Janos J, Rabideau DJ, Kamali M, McInnis MG, Bobo WV, Friedman ES, Gao K, Tohen M, Reilly-Harrington NA, Ketter TA, Calabrese JR, McElroy SL, Thase ME, Shelton RC, Bowden CL, Kocsis JH, Deckersbach T, Nierenberg AA. Clinical correlates of acute bipolar depressive episode with psychosis. J Affect Disord. 2017 Mar 30;217:29-33. doi: 10.1016/j.jad.2017.03.059. [Epub ahead of print] PubMed PMID: 28365478.
  • Cohen GH, Fink DS, Sampson L, Tamburrino M, Liberzon I, Calabrese JR, Galea S. Coincident alcohol dependence and depression increases risk of suicidal ideation among Army National Guard soldiers. Ann Epidemiol. 2017 Mar;27(3):157-163.e1. doi: 10.1016/j.annepidem.2016.12.004. Epub 2016 Dec 14. PubMed PMID: 28139369.
  • Köhler-Forsberg O, Sylvia L, Thase M, Calabrese JR, Deckersbach T, Tohen M, Bowden CL, McInnis M, Kocsis JH, Friedman ES, Ketter TA, McElroy S, Shelton RC, Nierenberg AA. Nonsteroidal anti-inflammatory drugs (NSAIDs) and paracetamol do not affect 6-month mood-stabilizing treatment outcome among 482 patients with bipolar disorder. Depress Anxiety. 2017 Mar;34(3):281-290. doi: 10.1002/da.22601. Epub 2017 Jan 30. PubMed PMID: 28135023.
  • Calabrese JR, Sanchez R, Jin N, Amatniek J, Cox K, Johnson B, Perry P, Hertel P, Such P, Salzman PM, McQuade RD, Nyilas M, Carson WH. Efficacy and Safety of Aripiprazole Once-Monthly in the Maintenance Treatment of Bipolar I Disorder: A Double-Blind, Placebo-Controlled, 52-Week Randomized Withdrawal Study. J Clin Psychiatry. 2017 Mar;78(3):324-331. doi: 10.4088/JCP.16m11201. PubMed PMID: 28146613.
  • Calabrese JR, Gao K, Sachs G. Diagnosing Mania in the Age of DSM-5. Am J Psychiatry. 2017 Jan 1;174(1):8-10. doi: 10.1176/appi.ajp.2016.16091084. PubMed PMID: 28040998.
  • Gao K, Fang F, Wang Z, Calabrese JR. Subjective Versus Objective Weight Gain During Acute Treatment With Second-Generation Antipsychotics in Schizophrenia and Bipolar Disorder. J Clin Psychopharmacol. 2016 Dec;36(6):637-642. Review. PubMed PMID: 27753728.
  • Fink DS, Calabrese JR, Liberzon I, Tamburrino MB, Chan P, Cohen GH, Sampson L, Reed PL, Shirley E, Goto T, D’Arcangelo N, Fine T, Galea S. Retrospective age-of-onset and projected lifetime prevalence of psychiatric disorders among U.S. Army National Guard soldiers. J Affect Disord. 2016 Sep 15;202:171-7. doi: 10.1016/j.jad.2016.05.025. Epub 2016 May 18. PubMed PMID: 27262639; PubMed Central PMCID: PMC4947427.
  • Fang F, Sun H, Wang Z, Ren M, Calabrese JR, Gao K. Antipsychotic Drug-Induced Somnolence: Incidence, Mechanisms, and Management. CNS Drugs. 2016 Sep;30(9):845-67. doi: 10.1007/s40263-016-0352-5. Review. PubMed PMID: 27372312.
  • Ganocy SJ, Goto T, Chan PK, Cohen GH, Sampson L, Galea S, Liberzon I, Fine T, Shirley E, Sizemore J, Calabrese JR, Tamburrino MB. Association of Spirituality With Mental Health Conditions in Ohio National Guard Soldiers. J Nerv Ment Dis. 2016 Jul;204(7):524-9. doi: 10.1097/NMD.0000000000000519. PubMed PMID: 27065107.
  • Fink DS, Chen Q, Liu Y, Tamburrino MB, Liberzon I, Shirley E, Fine T, Cohen GH, Galea S, Calabrese JR. Incidence and Risk for Mood and Anxiety Disorders in a Representative Sample of Ohio Army National Guard Members, 2008-2012. Public Health Rep. 2016 Jul-Aug;131(4):614-22. PubMed PMID: 27453607; PubMed Central PMCID: PMC4937124.
  • Oedegaard KJ, Alda M, Anand A, Andreassen OA, Balaraman Y, Berrettini WH, Bhattacharjee A, Brennand KJ, Burdick KE, Calabrese JR, Calkin CV, Claasen A, Coryell WH, Craig D, DeModena A, Frye M, Gage FH, Gao K, Garnham J, Gershon E, Jakobsen P, Leckband SG, McCarthy MJ, McInnis MG, Maihofer AX, Mertens J, Morken G, Nievergelt CM, Nurnberger J, Pham S, Schoeyen H, Shekhtman T, Shilling PD, Szelinger S, Tarwater B, Yao J, Zandi PP, Kelsoe JR. The Pharmacogenomics of Bipolar Disorder study (PGBD): identification of genes for lithium response in a prospective sample. BMC Psychiatry. 2016 May 5;16:129. doi: 10.1186/s12888-016-0732-x. PubMed PMID: 27150464; PubMed Central PMCID: PMC4857276.
  • Fink DS, Gallaway MS, Tamburrino MB, Liberzon I, Chan P, Cohen GH, Sampson L, Shirley E, Goto T, D’Arcangelo N, Fine T, Reed PL, Calabrese JR, Galea S. Onset of Alcohol Use Disorders and Comorbid Psychiatric Disorders in a Military Cohort: Are there Critical Periods for Prevention of Alcohol Use Disorders? Prev Sci. 2016 Apr;17(3):347-56. doi: 10.1007/s11121-015-0624-1. PubMed PMID: 26687202; PubMed Central PMCID: PMC4791188.
  • Gao K, Calabrese JR. Pharmacogenetics of lithium response: close to clinical practice? Lancet. 2016 Mar 12;387(10023):1034-6. doi: 10.1016/S0140-6736(16)00147-1. Epub 2016 Jan 22. PubMed PMID: 26806517.
  • Sylvia LG, Gold AK, Stange JP, Peckham AD, Deckersbach T, Calabrese JR, Weiss RD, Perlis RH, Nierenberg AA, Ostacher MJ. A randomized, placebo-controlled proof-of-concept trial of adjunctive topiramate for alcohol use disorders in bipolar disorder. Am J Addict. 2016 Mar;25(2):94-8. doi: 10.1111/ajad.12346. Epub 2016 Feb 19. PubMed PMID: 26894822; PubMed Central PMCID: PMC4791182.
  • Durgam S, Earley W, Lipschitz A, Guo H, Laszlovszky I, Németh G, Vieta E, Calabrese JR, Yatham LN. An 8-Week Randomized, Double-Blind, Placebo-Controlled Evaluation of the Safety and Efficacy of Cariprazine in Patients With Bipolar I Depression. Am J Psychiatry. 2015 Nov 6;appiajp201515020164. doi: 10.1176/appi.ajp.2015.15020164 Pubmed PMID: 26541814
  • Calabrese JR, Keck PE, Starace A, Lu K, Ruth A, Laszlovszky I, Németh G, Durgam S. Efficacy and safety of low- and high-dose cariprazine in acute and mixed mania associated with bipolar I disorder: a double-blind, placebo-controlled study. J Clin Psychiatry. 2015 Mar;76(3):284–292. doi: 10.4088/JCP.14m09081 Pubmed PMID: 25562205
  • Gao K, Yuan C, Wu R, Chen J, Wang Z, Fang Y, Calabrese JR. Important clinical features of atypical antipsychotics in acute bipolar depression that inform routine clinical care: a review of pivotal studies with number needed to treat. Neurosci Bull. 2015 Oct;31(5):572–588. doi: 10.1007/s12264-014-1534-0 Pubmed PMID: 2602495
  • Biehn TL, Contractor AA, Elhai JD, Tamburrino M, Fine TH, Cohen G, Shirley E, Chan PK, Liberzon I, Calabrese JR, Galea S. Latent dimensions of posttraumatic stress disorder and their relations with alcohol use disorder. Soc Psychiatry Psychiatr Epidemiol. 2015 Oct 31; doi: 10.1007/s00127-015-1135-x Pubmed PMID: 26520448
  • Contractor AA, Elhai JD, Fine TH, Tamburrino MB, Cohen G, Shirley E, Chan PK, Liberzon I, Galea S, Calabrese JR. Latent profile analyses of posttraumatic stress disorder, depression and generalized anxiety disorder symptoms in trauma-exposed soldiers. J Psychiatr Res. 2015 Sep;68:19–26. doi: 10.1016/j.jpsychires.2015.05.014 Pubmed PMID: 26228395
  • McElroy SL, Kemp DE, Friedman ES, Reilly-Harrington NA, Sylvia LG, Calabrese JR, Rabideau DJ, Ketter TA, Thase ME, Singh V, Tohen M, Bowden CL, Bernstein EE, Brody BD, Deckersbach T, Kocsis JH, Kinrys G, Bobo WV, Kamali M, McInnis MG, Leon AC, Faraone S, Nierenberg AA, Shelton RC. Obesity, but not metabolic syndrome, negatively affects outcome in bipolar disorder. Acta Psychiatr Scand. 2015 Jun 26; doi: 10.1111/acps.12460 Pubmed PMID: 26114830
  • Durham TA, Elhai JD, Fine TH, Tamburrino M, Cohen G, Shirley E, Chan PK, Liberzon I, Galea S, Calabrese JR. Posttraumatic stress disorder’s dysphoria dimension and relations with generalized anxiety disorder symptoms. Psychiatry Res. 2015 Jul 30;228(1):150–155. doi: 10.1016/j.psychres.2015.04.034 Pubmed PMID: 25983285

Contact Information

Contact Name: Joseph Calabrese
Contact Number: (216) 844-2400
Contact Email:  joseph.calabrese@UHhospitals.org