Calabrese, Joseph, MD

Research Statement

Research interests include improvement of clinical outcomes in under-served populations of bipolar disorder, including those with rapid cycling, children and adolescents, adults currently abusing alcohol and/or drugs, forensic complications of bipolar disorder, those receiving care within community mental health centers, older adults, and members of the Ohio national guard and reserve.

Professional Affiliations

  • Investigator, Cleveland FES Center
  • Director, Mood Disorders Program, University Hospitals Cleveland Medical Center, Cleveland, OH
  • Bipolar Disorders Research Chair & Professor of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, OH

Publications (Select)

  • Durgam S, Earley W, Lipschitz A, Guo H, Laszlovszky I, Németh G, Vieta E, Calabrese JR, Yatham LN. An 8-Week Randomized, Double-Blind, Placebo-Controlled Evaluation of the Safety and Efficacy of Cariprazine in Patients With Bipolar I Depression. Am J Psychiatry. 2015 Nov 6;appiajp201515020164. doi: 10.1176/appi.ajp.2015.15020164 Pubmed PMID: 26541814
  • Calabrese JR, Keck PE, Starace A, Lu K, Ruth A, Laszlovszky I, Németh G, Durgam S. Efficacy and safety of low- and high-dose cariprazine in acute and mixed mania associated with bipolar I disorder: a double-blind, placebo-controlled study. J Clin Psychiatry. 2015 Mar;76(3):284–292. doi: 10.4088/JCP.14m09081 Pubmed PMID: 25562205
  • Gao K, Yuan C, Wu R, Chen J, Wang Z, Fang Y, Calabrese JR. Important clinical features of atypical antipsychotics in acute bipolar depression that inform routine clinical care: a review of pivotal studies with number needed to treat. Neurosci Bull. 2015 Oct;31(5):572–588. doi: 10.1007/s12264-014-1534-0 Pubmed PMID: 2602495
  • Biehn TL, Contractor AA, Elhai JD, Tamburrino M, Fine TH, Cohen G, Shirley E, Chan PK, Liberzon I, Calabrese JR, Galea S. Latent dimensions of posttraumatic stress disorder and their relations with alcohol use disorder. Soc Psychiatry Psychiatr Epidemiol. 2015 Oct 31; doi: 10.1007/s00127-015-1135-x Pubmed PMID: 26520448
  • Contractor AA, Elhai JD, Fine TH, Tamburrino MB, Cohen G, Shirley E, Chan PK, Liberzon I, Galea S, Calabrese JR. Latent profile analyses of posttraumatic stress disorder, depression and generalized anxiety disorder symptoms in trauma-exposed soldiers. J Psychiatr Res. 2015 Sep;68:19–26. doi: 10.1016/j.jpsychires.2015.05.014 Pubmed PMID: 26228395
  • McElroy SL, Kemp DE, Friedman ES, Reilly-Harrington NA, Sylvia LG, Calabrese JR, Rabideau DJ, Ketter TA, Thase ME, Singh V, Tohen M, Bowden CL, Bernstein EE, Brody BD, Deckersbach T, Kocsis JH, Kinrys G, Bobo WV, Kamali M, McInnis MG, Leon AC, Faraone S, Nierenberg AA, Shelton RC. Obesity, but not metabolic syndrome, negatively affects outcome in bipolar disorder. Acta Psychiatr Scand. 2015 Jun 26; doi: 10.1111/acps.12460 Pubmed PMID: 26114830
  • Durham TA, Elhai JD, Fine TH, Tamburrino M, Cohen G, Shirley E, Chan PK, Liberzon I, Galea S, Calabrese JR. Posttraumatic stress disorder’s dysphoria dimension and relations with generalized anxiety disorder symptoms. Psychiatry Res. 2015 Jul 30;228(1):150–155. doi: 10.1016/j.psychres.2015.04.034 Pubmed PMID: 25983285

Contact Information

Contact Name: Joseph Calabrese
Contact Number: (216) 844-2400
Contact Email: